Version 2.77

Part Description

LP35390-1   Lipoprotein associated phospholipase A2
Lipoprotein associated phospholipase A2 (Lp-PLA2) is an enzyme currently being evaluated to assist in risk factor assessment of cardiovascular disease. This biomarker was previously known as platelet-activating factor acetylhydrolase (PAF-AH) and has two biological functions. One function is that Lp-PLA2 inactivates an important proinflammatory mediator known as platelet-activating factor (PAF). The other function of Lp-PLA2 is that is oxidatively hydrolyzes modified polyunsaturated fatty acids resulting in the chemical compounds lysophosphatidylcholine (LysoPC) and oxidized nonesterified fatty acids (OxNEFA). OxNEFA has powerful monocyte chemotactic activity. LysoPC increase inflammatory mediators such as cytokines, adhesion molecules and the chemotactic mediator MCP-1. LpPLA2 is positively associated with coronary disease but does not improve cardiovascular risk assessment over the traditional biomarkers. LpPLA2 has been more useful for assessing patients with a borderline risk than traditional biomarkers. LpPLA2 has been especially helpful when used to measure cardiac risk on patients with metabolic syndrome or diabetes. There is some speculation that LpPLA2 may eventually be used to monitor treatment efficacy. Future risk assessments for coronary disease will likely include multiple combinations of cardiac risk markers. PMID: 17892360 RefID 23065 Source: Regenstrief LOINC

Fully-Specified Name

Component
Lipoprotein associated phospholipase A2
Property
MCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Short Name
Lp-PLA2 SerPl-mCnc
Display Name
Lipoprotein associated phospholipase A2 [Mass/Vol]
Consumer Name Alpha Get Info
Lipoprotein Associated Phospholipase A2, Blood

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.15
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
4889

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Lipoproteina asociada a fosfolipasa A2:Concentración de masa:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Fosfolipasa A2 asociada a lipoproteínas:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:
fr-CA French (Canada) Phospholipase A2 associée aux lipoprotéines:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-FR French (France) Lipoprotéine associée à la phospholipase A2:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:
fr-BE French (Belgium) Phospholipase A2 associée aux lipoprotéines:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
it-IT Italian (Italy) Fosfolipasi A2 associata a lipoproteina:MCnc:Pt:Siero/Plasma:Qn:
Synonyms: Chimica Concentrazione di Massa Lipoproteine Plasma Punto nel tempo (episodio) Siero Siero o Plasma
ko-KR Korean (Korea, Republic Of) 지질단백 관련 인지질효소 A2:질량농도:검사시점:혈청/혈장:정량:
nl-NL Dutch (Netherlands) lipoproteïne geassocieerd fosfolipase A2:massa/volume:moment:serum of plasma:kwantitatief:
pl-PL Polish (Poland) Fosfolipaza A2 związana z lipoproteina:stężenie masowe:punkt w czasie:surowica lub osocze:ilościowy:
pt-BR Portuguese (Brazil) Lipoproteína associada a fosfolipase A2:MCnc:Pt:Sor/Plas:Qn:
Synonyms: Rk203; k203; Lp-PLA2; Platelet-activating factor acetylhydrolase; Lipoprot; Lip; Lp; Lipoproteins; Mass concentration; Level; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Quantitative; QNT; Quant; Quan; Assoc; Chemistry
ru-RU Russian (Russian Federation) Липопротеин ассоциированная фосфолипаза A2:МассКонц:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Количественный Массовая концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Lipoprotein ilişkili fosfolipaz A2:KütlKons:Zmlı:Ser/Plaz:Kant:
zh-CN Chinese (China) 脂蛋白相关磷脂酶 A2:质量浓度:时间点:血清/血浆:定量型:
Synonyms: A2 型 LP;成分 - 化学 - 脂蛋白;脂蛋白类 Lp-PLA2;脂蛋白相关性磷脂酶 A2;脂蛋白相关性磷酸脂酶 A2;脂蛋白相关磷酸脂酶 A2;血小板活化因子乙酰水解酶;血小板激活因子乙酰水解酶;血小板激活因子酰基脱水酶 关联的 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 有联系的 水平;浓度;质量浓度(单位体积) 相关的 磷酸脂酶 血清或血浆

Example Units

Unit Source
ng/dL REGENSTRIEF
ng/mL Example UCUM Units
ng/mL REGENSTRIEF

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=39804-0