40553-0
CD19 Ag [Presence] in Tissue by Immune stain
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Part Descriptions
LP17759-9 CD19
CD19 (Cluster of Differentiation 19), is a human protein encoded by the CD19 gene.
Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells.
It primarily acts as a B cell co-receptor in conjunction with CD21 and CD81.
Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated which leads to binding by Src-family kinases and recruitment of PI-3 kinase.
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Source: Wikipedia,
CD18
LP17759-9 CD19
The CD19+ B cells are 95 kilo Dalton transmembrane glycoproteins and are comprised of a single transmembrane domain, a cytoplasmic C-terminus, and an extracellular N-terminus. It is a biomarker for normal and neoplastic B cells and for dendritic cells. CD19+ B cells regulate signaling thresholds by modifying B cell receptor dependent and independent signaling, functioning as a dominant piece of a multimolecular complex that resides on the mature B cell surface. The concentration of CD19 on the surface of B cells is tightly controlled throughout the cell's development, making it a very valuable biomarker for B cells. Mature B cells have three times the number of CD19 antigens than immature B cells, and when B cells differentiate into plasma cells, the expression of CD19 is lost. Patients who lack sufficient CD19 antigens have a lower response to transmembrane signals and weak T cell dependent antibody responses. CD19 is highly conserved and expressed in most B cell malignancies including acute lymphocytic leukemia, B cell lymphoma, and B cell leukemia. Efforts are in play to utilize CD19 antibodies for the treatment of lymphoma, leukemia, and autoimmune disorders. PMID: 23210908
Source: Regenstrief LOINC
LOINC Names Get Info
- Fully-Specified Name
- CD19 Ag:
PrThr: Pt: Tiss: Ord: Immune stain - Long Common Name
- CD19 Ag [Presence] in Tissue by Immune stain
- Short Name
- CD19 Ag Tiss Ql ImStn
- Display Name
- CD19 Ag Immune stain Ql (Tiss)
- Consumer Name Alpha Get Info
- CD19 antigen, Tissue
Part Model Get Info
Basic Attributes
- Class
- CELLMARK
- Type
- Laboratory
- First Released
- Version 2.15
- Last Updated
- Version 2.56 (MIN)
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | CD19 Ag: |
| el-GR | Greek (Greece) | CD19 Αντιγόνο: Synonyms: CD19 CELLMARK Ord PrThr Pt Ανοσολογική χρώση Αντιγόνο Ιστός |
| es-ES | Spanish (Spain) | Células CD19+ Antígeno: |
| es-MX | Spanish (Mexico) | CD19 Ag: |
| et-EE | Estonian (Estonia) | CD19 antigeen: Synonyms: Järgarvuline Juhuslik Kude |
| fr-CA | French (Canada) | CD19, Ag: |
| fr-FR | French (France) | CD19 Ag: |
| fr-BE | French (Belgium) | CD19 Ag: Synonyms: Antigène Cellules.CD19+ Coloration. Méthode mmunologique |
| it-IT | Italian (Italy) | CD19, Ag: Synonyms: Modelli di superficie cellulare Presenza o Soglia Punto nel tempo (episodio) Tessuto & |
| ko-KR | Korean (Korea, Republic Of) | CD19 항원: |
| nl-NL | Dutch (Netherlands) | CD19 Ag: Synonyms: antigeen |
| pl-PL | Polish (Poland) | CD19 Ag: Synonyms: Antygen CD19 CD19 |
| pt-BR | Portuguese (Brazil) | CD19 Ag: Synonyms: Leu-12; |
| ru-RU | Russian (Russian Federation) | CD19 Аг: Synonyms: Порядковый Ткань и мазки Точка во времени; |
| tr-TR | Turkish (Turkey) | CD19 Ag: Synonyms: Antijen Mevcut |
| zh-CN | Chinese (China) | CD19 抗原: Synonyms: Ag B4; |
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LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://