40792-4

Coproporphyrin 1 [Moles/time] in 24 hour Urine

Active

Part Description

LP18633-5 Coproporphyrin 1
Coproporhyrin I is a porphyrin metabolite arising from heme synthesis. Porphyrins are pigments found in both animal and plant life. Coproporphyrin I is a tetrapyrrole dead-end product from the spontaneous oxidation of the methylene bridges of coproporphynogen, arising from heme synthesis and secreted in feces and urine. Increased levels of coproporphyrins can indicate congenital erythropoietic porphyria or sideroblastic anaemia. Porphyria is a pathological state characterised by abnormalities of porphyrin metabolism and results in the excretion of large quantities of porphyrins in the urine and in extreme sensitivity to light. A large number of factors are capable of increasing porphyrin excretion, owing to different and multiple causes and etiologies: 1) the main site of the chronic hepatic porphyria disease process concentrates on the liver, 2) a functional and morphologic liver injury is almost regularly associated with this chronic porphyria, 3) the toxic form due to occupational and environmental exposure takes mainly a subclinical course. Hepatic factors includes disturbance in coproporphyrinogen metabolism, which results from inhibition of coproporphyrinogen oxidase as well as from the rapid loss from, and diminished utilization of coproporphyrinogen in the hepatocytes, which may also explain why coproporphyrin, its autoxidation product, predominates physiologically in the urine; decreased biliary excretion of coproporphyrin leading to a compensatory urinary excretion, so that the coproporphyrin ring isomer ratio (1:III) becomes a sensitive index for impaired liver function and intrahepatic cholestasis; and disturbed activity of hepatic uroporphyrinogen decarboxylase. In itself, secondary coproporphyrinuria is not associated with porphyria symptoms of a hepatologic-gastroenterologic, neurologic, or dermatologic order, even though coproporphyrinuria can occur with such symptoms. PMID: 3327428 Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Corproporphyrin I

LOINC Names Get Info

Fully-Specified Name: Coproporphyrin 1:SRat:24H:Urine:Qn:
Long Common Name: Coproporphyrin 1 [Moles/time] in 24 hour Urine
Short Name: Copro1 24h Ur-sRate
Display Name: Coproporphyrin 1 (24H U) [Moles/Time]
Consumer Name Alpha Get Info: Coproporphyrin 1, Urine

Part Model Get Info

Component
Coproporphyrin 1
LP18633-5
- Analyte
  Coproporphyrin 1
  LP18633-5
  - Component Numerator
    Coproporphyrin 1
    LP18633-5
    - Component Numerator Core
      Coproporphyrin 1
      LP18633-5
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
SRat
LP6867-8
Time
24H
LP6924-7
- Time Core
  24H
  LP6924-7
- Time Modifier
  NULL
System
Urine
LP7681-2
- System Core
  Urine
  LP7681-2
- Super System
  NULL
Scale
Qn
LP7753-9
Method
NULL

Basic Attributes

Class: CHEM
Type: Laboratory
First Released: Version 2.15
Last Updated: Version 2.70 (MIN)
Order vs. Observation: Observation

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Koproporfyrin 1:Látkový tok:24 hodin:Moč:Kvantitativní:
el-GR	Greek (Greece)	Κοπροπορφυρίνη 1:SRat:24H:Ούρα:Qn: Synonyms: 24H CHEM Qn SRat Κοπροπορφυρίνη Κοπροπορφυρίνη 1 Ούρα
es-ES	Spanish (Spain)	Coproporfirina 1:Indice de susbtancia:24 horas:Orina:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Coproporfirina 1:Tasa de sustancia:24H:Orina:Cuantitativo:
et-EE	Estonian (Estonia)	Koproporfüriin 1:SRat:24 tunni:U:Qn: Synonyms: Aine määr Kvantitatiivne Uriin
fr-CA	French (Canada)	Coproporphyrine 1:Débit de substance:24 h:Urine:Quantitatif:
fr-FR	French (France)	Coproporphyrine 1:Moles/Temps:24H:Urine:Numérique:
fr-BE	French (Belgium)	Coproporphyrine 1:Débit de substance:24 h:Urine:Quantitatif:
it-IT	Italian (Italy)	Coproporfirina 1:SRat:24h:Urine:Qn: Synonyms: 24 Ore Chimica Tasso di sostanza
ko-KR	Korean (Korea, Republic Of)	코프로포르피린 1:물질비:24시간:뇨:정량:
nl-NL	Dutch (Netherlands)	coproporfyrine 1:mol/tijd:24 uur:urine:kwantitatief: Synonyms: 24U
pt-BR	Portuguese (Brazil)	Coproporfirina 1:SRat:24H:Urina:Qn: Synonyms: ; Copro1; Coproporphyrin I; Coproporphyrins; Copro; Tetracarboxyporphyrin; Coproporph; Tetracarboxyl porphyrin; Tetracarboxylporphyrin; Tetracarboxylporphyrins; sRate; Substance rate; 1 day; 24 hours; 24HR; Ur; UR; Urn; UA; Quantitative; QNT; Quant; Quan; Chemistry
ru-RU	Russian (Russian Federation)	Копропорфирин 1:МольРасх:24 часа:Моча:Колич: Synonyms: Количественный Молярная скорость;Молярный расход
tr-TR	Turkish (Turkey)	Koproporfirin 1:SubHz:24Sa:İdrar:Kant:
zh-CN	Chinese (China)	粪卟啉 I:物质的量速率:24小时:尿液:定量型: Synonyms: 1天;1日;24.0小时;一天;一日;二十四个小时;二十四小时 Ⅰ Copro;Coproporph;四羧基卟啉 Copro1;粪卟啉 1;粪卟啉Ⅰ I 克分子速率;克分子速率(单位时间);摩尔速率;摩尔速率(单位时间);物质的量速率(单位时间) 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类可用数量表示的;定量性;数值型;数量型;连续数值型标尺尿;小便;下泉

Example Units

Unit	Source
nmol/(24.h)	Example UCUM Units
nmol/24 hr	eCHN

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Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.