LOINC
Version 2.66

41995-2Hemoglobin A1c [Mass/volume] in BloodActive

Component
Hemoglobin A1c
Property
MCnc
Time
Pt
System
Bld
Scale
Qn
Method

Additional Names

Short Name
Hgb A1c Bld-mCnc
Display Name Beta
HbA1c (Bld) [Mass/Vol]
Consumer Name Alpha
HbA1c, Blood

Part Description

LP16413-4   Hemoglobin A1c
Currently (2010), four standardization protocols exist for measuring Hgb A1c:

1. IFCC - designated as a Reference Method or RM (http://www.ifcchba1c.net/)
2. NGSP - the long standing protocol used in the US and most other countries since the DCCT study (http://www.ngsp.org/factors.asp)
3.JDS/JSCC - a protocol used in Japan, Spain and possibly other countries
4. Swedish - used in Sweden at least

Protocols 2-4 are known as Designated Comparison Methods (DCM) and have been connected to the Reference Method and each other through various regression equations.

Because of the high degrees of standardization within protocol it should no longer be necessary to specify a LOINC code with a method such as “HPLC”, “electrophoresis” or anything else. Analytical instruments will be designed so that an Hgb A1c result can be traced back to a specific standardization protocol, so the important distinction will be the standardization protocol as described above and which will be carried in the method field.

A meeting of instrument manufacturers (presumably including Japanese) in Milan, Italy, December 12, 2007, agreed (among other items) that:

-All manufacturers should implement worldwide the traceability to the IFCC reference system for Hgb -A1c.
-All new instruments sold after January 1st, 2011 will report (as a result of an Hgb A1c test) both SI (mmol/mol – no decimals) and NGSP derived units (percentage – one decimal), in agreement with the Consensus Statement.
-Note they only committed to supporting protocol (1) and (2)

Different countries are adopting the international harmonization recommendations in different ways. We have information from the NGSP that the US will continue to report only Hgb A1c/NGSP, with the unit percent – i.e., no change. In Great Britain, labs have already started to report all results both as Hgb A1c (NGSP) in % and Hgb A1c (IFCC) in mmol/mol. In Canada, they are awaiting a recommendation from an expert panel. Any of these measures could be reported in the same units, but the convention for the reporting Hgb A1c under the new IFCC protocol will be to use units of mmol/mol to avoid confusion between the DCCT/NGSP and the IFFCC protocol.

LOINC has defined 59261-8 (Hemoglobin A1c/Hemoglobin.total in Blood) by IFCC protocol.

These protocols produce different results when expressed in the same units. For example, the equivalent of Hgb A1c (NGSP) of 6.5% is Hgb A1c (IFCC) is 4.8%.

The NGSP web site (http://www.ngsp.org/factors.asp) suggests the use of alternate measures, such as glycated albumen, for patients with severe iron deficiency, dialysis patients, and those with SS SC CC because of over or under reading that can occur with these interferences. It also describes the effect of abnormal hemoglobins on results of HbA1c by instrument. Source: Regenstrief Help

Basic Attributes

Class
HEM/BC
Type
Laboratory
First Released
Version 2.16
Last Updated
Version 2.34
Order vs. Observation
Both

Reference Information

Type Source Reference
Webcontent Lab Tests Online®Copyright Copyright 2001-2019 American Association for Clinical Chemistry. Hemoglobin A1c

Language Variants Get Info

zh-CNChinese (China)
血红蛋白 A1c:质量浓度:时间点:全血:定量型:
nl-NLDutch (Netherlands)
hemoglobine A1c:massa/volume:moment:bloed:kwantitatief:
et-EEEstonian (Estonia)
Hemoglobiin A1c:MCnc:Pt:B:Qn:
fr-BEFrench (Belgium)
Hémoglobine A1c:Concentration de masse:Temps ponctuel:Sang:Quantitatif:
fr-CAFrench (Canada)
Hémoglobine A1c:Concentration de masse:Temps ponctuel:Sang:Quantitatif:
fr-FRFrench (France)
Hemoglobin A1c:MCnc:Pt:Bld:Qn:
de-ATGerman (Austria)
Hämoglobin A1c
el-GRGreek (Greece)
Αιμοσφαιρίνη Α1c (γλυκοζυλιωμένη):Συγκέντρωση μάζας:Χρονική στιγμή:Αίμα:Ποσοτική:
it-ITItalian (Italy)
Emoglobina A1c:MCnc:Pt:Sangue:Qn:
ko-KRKorean (Korea, Republic of)
혈색소 A1C:질량농도:검사시점:전혈:정량:
pt-BRPortuguese (Brazil)
Hemoglobina A1c:MCnc:Pt:SgTotal:Qn:
ru-RURussian (Russian Federation)
Гемоглобин А1с:МассКонц:ТчкВрм:Кр:Колич:
es-ESSpanish (Spain)
Hemoglobina A1c (Hemoglobina glicosilada):Concentración de masa:Punto temporal:Sangre:Qn:
tr-TRTurkish (Turkey)
Hemoglobin A1c:KütlKons:Zmlı:Kan:Kant:

Example Units

Unit Source
g/dL Example UCUM Units
g/dL Original Submission

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=41995-2