LOINC
Version 2.73

42501-7Glutamate decarboxylase 65 Ab [Units/volume] in Cerebral spinal fluidActive

Part Description

LP18489-2   Glutamate decarboxylase 65
Glutamate decarboxylase 65 (GAD65) antibody is useful to diagnose insulin dependent diabetes mellitus (IDDM, Type I diabetes), to assess the risk for developing IDDM, to predict the onset of IDDM and the risk of developing related endocrine disorders such as thyroiditis. Before clinical onset, Type I diabetes is characterized by lymphocytic infiltration of the islet cells and by circulating autoantibodies against a variety of islet cell antigens including GAD-65, IA-2 (a tyrosine phosphatase-like protein), and insulin (IAA). GAD has two isoforms, GAD65 and GAD67, which are highly homologous but found in distinct subsets of patients. [PMID:7532143] GAD65 antibodies are specific to patients with insulin-dependent diabetes. The presence of GAD antibodies in a patient recently diagnosed with diabetes indicates a high risk of requiring insulin within three years.[PMID:11114103] GAD67 is important to the maturation of perisomatic innervation.( http://www.sciencedirect.com/science/article/pii/S0896627307003728) GAD65 are also associated with paraneoplastic neurologic syndrome (PNS) which is an autoimmune disorder that is manifested by progressive neurological syndromes of any combination of the central, peripheral and autonomic nervous systems. In addition, the different PNS antibodies are associated with certain cancers and can assist in identifying where an unknown tumor is located.[PMID:22412264] Glutamic acid decarboxylase 65 antibody are associated with stiff person syndrome, cerebellar ataxia encephalitis and other neurological diseases.[PMID:22405456] Source: Regenstrief LOINC

Fully-Specified Name

Component
Glutamate decarboxylase 65 Ab
Property
ACnc
Time
Pt
System
CSF
Scale
Qn
Method

Additional Names

Short Name
GAD65 Ab CSF-aCnc
Display Name
Glutamate decarboxylase 65 Ab Qn (CSF)
Consumer Name Alpha
Glutamate decarboxylase 65 antibody, Spinal fluid

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.16
Last Updated
Version 2.73
Order vs. Observation
Both
Common US Lab Results Rank
13352

Member of these Groups

LG50123-5 Glutamate decarboxylase 65 Ab|ACnc|Pt|CSF

Language Variants Get Info

zh-CNChinese (China)
谷氨酸脱羧酶-65 抗体:任意型浓度:时间点:脑脊液:定量型:
nl-NLDutch (Netherlands)
glutamaatdecarboxylase 65 As:eenheid/volume:moment:liquor cerebrospinalis:kwantitatief:
et-EEEstonian (Estonia)
Glutamaadi dekarboksülaasi 65 vastased antikehad:Acnc:Pt:CSF:Qn:
fr-BEFrench (Belgium)
Glutamate décarboxylase 65 Ac:Concentration arbitraire:Temps ponctuel:LCR:Quantitatif:
fr-CAFrench (Canada)
Glutamate décarboxylase 65 , Ac:Concentration arbitraire:Temps ponctuel:LCR:Quantitatif:
fr-FRFrench (France)
Glutamate décarboxylase 65 anticorps:Arbitraire/Volume:Ponctuel:Liquide céphalorachidien:Numérique:
it-ITItalian (Italy)
Glutammato decarbossilasi 65 Ab:ACnc:Pt:LCS:Qn:
ko-KRKorean (Korea, Republic of)
글루탐산탈탄산효소 65 항체:임의농도:검사시점:뇌척수액:정량:
pt-BRPortuguese (Brazil)
Glutamato Descarboxilase 65 Ac:ACnc:Pt:LCR:Qn:
ru-RURussian (Russian Federation)
Глутаматдекарбоксилаза 65 Ат:ПроизвКонц:ТчкВрм:ЦСЖ:Колич:
es-MXSpanish (Mexico)
Glutamato descarboxilasa 65 Ab:Concentración arbitraria:Punto temporal:Fluído espinal cerebral:Cuantitativo:
es-ESSpanish (Spain)
Glutamato decarboxilasa 65 Anticuerpos:Concentración arbitraria:Punto temporal:Líquido Cefalorraquideo:Qn:
tr-TRTurkish (Turkey)
Glutamat dekarboksilaz 65 Ab:SçKons:Zmlı:BOS:Kant:

Example Units

Unit Source
[arb'U]/mL Example UCUM Units

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=42501-7