42788-0
Insulin-like growth factor-I receptor Ag [Presence] in Tissue by Immune stain
Active
Part Description
LP36220-9 Insulin-like growth factor-I receptor
The Insulin-like Growth Factor 1 (IGF-1) Receptor is a transmembrane receptor that is activated by IGF-1 and by the related growth factor IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF-1 plays an important role in growth and continues to have anabolic effects in adults - meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Mice lacking the IGF-1 receptor die late in development, and show a dramatic reduction in body mass, testifying to the strong growth-promoting effect of this receptor. Mice carrying only one functional copy of igf1r are normal, but exhibit a ~15% decrease in body mass.
The IGF-1R is implicated in several cancers,[4][5] including both breast and prostate cancer. In some instances its anti-apoptotic properties allow cancerous cells to resist the cytotoxic properties of chemotheraputic drugs or radiotherapy. In breast cancer, where EGFR inhibitors such as erlotinib are being used to inhibit the EGFR signaling pathway, IGF-1R confers resistance by forming one half of a heterodimer (see the description of EGFR signal transduction in the erlotinib page), allowing EGFR signaling to resume in the presence of a suitable inhibitor. This process is referred to as crosstalk between EGFR and IGF-1R. It is further implicated in breast cancer by increasing the metastatic potential of the original tumour by inferring the ability to promote vascularisation.
Increased levels of the IGF-IR are expressed in the majority of primary and metastatic prostate cancer patient tumors.Evidence suggests that IGF-IR signaling is required for survival and growth when prostate cancer cells progress to androgen independence. In addition, when immortalized prostate cancer cells mimicking advanced disease are treated with the IGF-1R ligand, IGF-1, the cells become more motile.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia, Wikipedia
Fully-Specified Name
- Component
- Insulin-like growth factor-I receptor Ag
- Property
- PrThr
- Time
- Pt
- System
- Tiss
- Scale
- Ord
- Method
- Immune stain
Additional Names
- Short Name
- IGF-IR Ag Tiss Ql ImStn
- Display Name
- Insulin-like growth factor-I receptor Ag Immune stain Ql (Tiss)
- Consumer Name Alpha Get Info
- Insulin-like growth factor-I receptor antigen, Tissue
Basic Attributes
- Class
- PATH
- Type
- Laboratory
- First Released
- Version 2.16
- Last Updated
- Version 2.56
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Receptor del factor I de crecimiento tipo insulina Antígeno: |
| es-MX | Spanish (Mexico) | Receptor Ag del factor de crecimiento similar a la insulina I: |
| et-EE | Estonian (Estonia) | Insuliinisarnane kasvufaktori 1 retseptor antigeen: Synonyms: Järgarvuline Juhuslik Kude |
| fr-CA | French (Canada) | Récepteur à facteur de croissance insulinomimétique-I, Ag: |
| fr-FR | French (France) | IGF-1 récepteur antigène: |
| fr-BE | French (Belgium) | Récepteur . facteur de croissance insulinomimétique-I Ag: Synonyms: Antigène Coloration. Méthode mmunologique IGF IGF-I. Récepteur |
| it-IT | Italian (Italy) | Fattore di crescita insulino-simile I, recettore, Ag: Synonyms: Patologia Presenza o Soglia Punto nel tempo (episodio) Recettore del fattore di crescita insulino-simile Tessuto & |
| nl-NL | Dutch (Netherlands) | insulin-like growth factor-I-receptor Ag: Synonyms: antigeen |
| pt-BR | Portuguese (Brazil) | Receptor de Fator-I de crescimento Insulin-like(IGF-1) Ag: Synonyms: ; |
| ru-RU | Russian (Russian Federation) | Инсулиноподобный ростовой фактор-I рецептор Аг: Synonyms: Порядковый Ткань и мазки Точка во времени; |
| tr-TR | Turkish (Turkey) | İnsülin benzeri büyüme faktörü-I reseptörü Ag: Synonyms: Antijen Mevcut |
| zh-CN | Chinese (China) | 胰岛素样生长因子-I受体 抗原: Synonyms: "sliding scale" 胰岛素剂量调整法; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=42788-0
LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright