Version 2.77

Part Descriptions

LP36423-9   Ganglioside GM1
Gangliosides are a family of molecules that are present throughout the body but especially prevalent in cells of the nervous system. Specific gangliosides are named for the carbohydrate sequence they contain and have a unique distribution within the nervous system. The oligosaccharide groups on gangliosides act as cell surface markers that play a role in cellular recognition and cell-to-cell communication, and they also act as specific receptors for certain pituitary glycoprotein hormones and certain bacterial protein toxins such as cholera toxin.
Anti-ganglioside antibodies, primarily IgG, are present in the sera from approximately 60% of patients with Guillain-Barré syndrome (GBS), and antibodies against different gangliosides are associated with different forms of GBS.
1. Antibodies against GD1a/GD1b and GD1b/GT1b complexes have been found in patients with more severe GBS requiring mechanical ventilation;
2. Antibodies against GM1 or those against GalNAc-GD1a have been associated with acute motor axonal neuropathy;
3. Anti-GQ1b antibodies are specifically associated with a variant of GBS called Fisher syndrome, which is characterized by ophthalmoplegia and ataxia.
Detection of specific markers early in the course of GBS may help guide the plan of care. PMID: 21214559 Source: Regenstrief LOINC, PMID: 2121455

LP222219-0   Ganglioside
A ganglioside molecule consists of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acid residues linked to the sugar chain. Molecules with one sialic acid residue are called monosialogangliosides (GM), those with two are called disialogangliosides (GD), and those with three are trisialogangliosides (GT). Gangliosides without any sialic acid residues are called asialogangliosides, while those that do not have a ceramide N-acyl group are called lysogangliosides. The number that typically is included at the end of the name indicates the order in which the molecule was discovered. For example, GM2 is a ganglioside with one sialic acid residue that was the second GM to be identified. Source: Regenstrief LOINC

Fully-Specified Name

Component
Ganglioside GM1 Ab.IgG
Property
Titr
Time
Pt
System
Ser
Scale
SemiQn
Method
IA

Additional Names

Short Name
GM1 Gangl IgG Titr Ser IA
Display Name
Ganglioside GM1 IgG IA (S) [Titer]
Consumer Name Alpha Get Info
Ganglioside GM1 IgG antibody, Blood

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.17
Last Updated
Version 2.75
Change Reason
The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both
Common Test Rank Get Info
6182

Member of these Panels

LOINC Long Common Name
82455-7 Ganglioside Ab panel - Serum

Member of these Groups Get Info

LOINC Group Group Name
LG17144-3 Ganglioside GM1 Ab.IgG|Titr|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
es-MX Spanish (Mexico) Gangliósido GM1 Ab.IgG:Título:Punto temporal:Suero:Cuantitativo:Inmunoensayo
es-ES Spanish (Spain) Gangliósido GM1 IgG:Titulo / Factor de dilución:Punto temporal:Suero:Semicuantitativo:IA
Synonyms: Semicuantitativo
fr-FR French (France) Ganglioside GM1 anticorps IgG:Titre:Ponctuel:Sérum:Numérique:Immunoanalyse
fr-CA French (Canada) Ganglioside GM1 , IgG:Titre:Temps ponctuel:Sérum:SemiQn:IA
it-IT Italian (Italy) Ganglioside GM1 Ab.IgG:Titr:Pt:Siero:SemiQn:IA
Synonyms: anticorpi IgG anticorpo Immunoassay Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant Titolo
nl-NL Dutch (Netherlands) ganglioside GM1 As.IgG:titer:moment:serum:semikwantitatief:immunoassay
Synonyms: antistof; antilichaam IA
pt-BR Portuguese (Brazil) Gangliosideo GM1 Ac.IgG:Título:Pt:Soro:Qn:Imunoensaio
Synonyms: Immune globulin G; Immunoglobulin G; GM1 Gangl; Dilution factor; Titer; Titre; Ttr; Titered; Point in time; Random; Serum; SR; Quantitative; QNT; Quant; Quan; Enzyme immunoassay; ELISA; MEIA; SUDS; ELFA; IAA; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; Serology
zh-CN Chinese (China) 神经节苷脂 GM1 抗体.IgG:滴定度:时间点:血清:半定量型:免疫测定法
Synonyms: Ab.IgG;IgG;抗体 IgG Ab;自身抗体 GM1;神经节糖苷 GM1 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 免疫球蛋白 G 效价;滴定浓度;滴定率;滴定量;滴度;稀释倍数;稀释因子;稀释系数 时刻;随机;随意;瞬间 神经节糖苷 神经节苷脂 GM1 Ab 神经节苷脂 GM1 Ab.IgG 神经节苷脂 GM1 IgG 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Example Units

Unit Source
{titer} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=43240-1