43368-0
Microsatellite instability [Identifier] in Tissue by Molecular genetics method Nominal
Active
Part Descriptions
LP36464-3 Microsatellite instability
The appearance of abnormally long or short microsatellites in an individual's DNA is referred to as microsatellite instability. Microsatellite instability (MSI) is a condition manifested by damaged DNA due to defects in the normal DNA repair process. Sections of DNA called microsatellites, which consist of a sequence of repeating units of 1-6 base pairs in length, become unstable and can shorten or lengthen. Microsatellites are also known as simple sequence repeats (SSRs).
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Source: Wikipedia, Wikipedia
LP36464-3 Microsatellite instability
Microsatellite instability (MSI) is a change in the number of repeats of a specific DNA marker in cancer cells compared to the number of repeats present in non-cancerous cells of the same patient. Different tumor types are associated with different MSI markers, and both the presence of MSI in specific markers as well as the the number of distinct markers demonstrating MSI is important. Tumor cells are classified as being stable, having high instability (MSI-H), or having low instability (MSI-L) based on the number of markers demonstrating MSI. MSI analysis may help guide therapy and be a prognostic indicator. Specific MSI markers include BAT25, BAT26, D2S123, D5S346, D17S2720, NR21, NR24 and MONO27. MSI has been most studied in colorectal cancer, and colorectal tumors that are MSI-H are more likely to be carcinomas than adenomas. MSI has also been studied in other types of cancer, including gastric cancer, breast cancer, lung cancer and Wilms tumor.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Microsatellite instability
- Property
- Prid
- Time
- Pt
- System
- Tiss
- Scale
- Nom
- Method
- Molgen
Additional Names
- Short Name
- MSI Tiss
- Display Name
- Microsatellite instability Molgen Nom (Tiss)
- Consumer Name Alpha Get Info
- Microsatellite instability, Tissue
Basic Attributes
- Class
- MOLPATH
- Type
- Laboratory
- First Released
- Version 2.17
- Last Updated
- Version 2.73
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 10809
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Inestabilidad microsatelite: |
| es-MX | Spanish (Mexico) | Inestabilidad de microsatélites: |
| fr-FR | French (France) | Microsatellite instabilité: |
| it-IT | Italian (Italy) | Microsatelliti, instabilità: Synonyms: Genetica molecolare Instabilità dei microsatelliti Patologia molecolare Presenza o Identità Punto nel tempo (episodio) Tessuto & |
| nl-NL | Dutch (Netherlands) | microsatellietinstabiliteit: Synonyms: molgen |
| pt-BR | Portuguese (Brazil) | Instabilidade de Microsatélites: Synonyms: ; |
| ru-RU | Russian (Russian Federation) | Микросателлитная нестабильность: Synonyms: Номинальный; |
| tr-TR | Turkish (Turkey) | Mikrosatellit kararsızlık: |
| zh-CN | Chinese (China) | 微卫星不稳定性: Synonyms: MSI 分子病理学; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
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LOINC Copyright
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