Version 2.78

Part Descriptions

LP16474-6   Interleukin 6
Interleukin-6 (IL-6) is a protein that in humans is encoded by the IL6 gene.

IL-6 is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. In terms of host response to a foreign pathogen, IL-6 has been shown, in mice, to be required for resistance against the bacterium, Streptococcus pneumoniae. IL-6 is also a "myokine," a cytokine produced from muscle, and is elevated in response to muscle contraction. It is significantly elevated with exercise, and precedes the appearance of other cytokines in the circulation. During exercise, it is thought to act in a hormone-like manner to mobilize extracellular substrates and/or augment substrate delivery. Additionally, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine. IL-6's role as an anti-inflammatory cytokine is mediated through its inhibitory effects on TNF-alpha and IL-1, and activation of IL-1ra and IL-10. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LP16474-6   Interleukin 6
The Interleukins belong to the family termed cytokines. They are peptides used by immune and inflammatory cells to communicate and control cell operations. The cytokines have some similar actions to the Growth Factors but Growth Factors regulate proliferation of non-immune cells. Interleukin 6 is a 25,000 molecular weight glycoprotein produced primarily in macrophages, T cells, fibroblasts and endothelial cells. Its primary target cells are T and B cells and neutrophils. Its main actions are involvement in terminal differentiation of B cells to antibody secreting plasma cells, activation of T cells and stimulation of hepatocyte production of acute phase proteins. Interleukin stimulates Prolactin, Growth Hormone, Luteinizing Hormone, Follicle Stimulating Hormone and ACTH. Release is stimulated by Interleukin 1a and b, Vasoactive Intestinal Polypeptide, and Prostaglandin E2. Release is not affected by aspirin or indomethacin. Levels are elevated in multiple myeloma, rheumatoid arthritis, systemic lupus erythematosus, meningococcus meningitis and infectious peritonitis. Source: Inter Science Institute, Inter Science Institute

Fully-Specified Name

Component
Interleukin 6
Property
PrThr
Time
Pt
System
Ser/Plas
Scale
Ord
Method

Additional Names

Short Name
Il6 SerPl Ql
Display Name
Interleukin 6 Ql
Consumer Name Alpha Get Info
Interleukin 6, Blood

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.17
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Interleukin-6:Nachweis oder Schwellenwert:Zeitpunkt:Serum oder Plasma:Ordinal:
Synonyms: IL-6
es-MX Spanish (Mexico) Interleucina 6:Presencia o umbral:Punto temporal:Suero o Plasma:Ordinal:
es-ES Spanish (Spain) Interleukina 6:PrThr:Punto temporal:Suero o Plasma:Ord:
et-EE Estonian (Estonia) Interleukiin 6:PrThr:Pt:S/P:Ord:
Synonyms: Järgarvuline Juhuslik Plasma Seerum Seerum või plasma
fr-CA French (Canada) Interleukine 6:Présence-Seuil:Temps ponctuel:Sérum/Plasma:Ordinal:
fr-FR French (France) Interleukine-6:Présence/Seuil:Ponctuel:Sérum/Plasma:Qualitatif:
fr-BE French (Belgium) Interleukine 6:PrThr:Temps ponctuel:Sérum/Plasma:Ordinal:
Synonyms: Il6
it-IT Italian (Italy) Interleuchina 6:PrThr:Pt:Siero/Plasma:Ord:
Synonyms: Chimica Plasma Presenza o Soglia Punto nel tempo (episodio) Siero Siero o Plasma
nl-NL Dutch (Netherlands) interleukine 6:aanwezigheid:moment:serum of plasma:ordinaal:
pt-BR Portuguese (Brazil) Interleucina 6:ACnc:Pt:Sor/Plas:Ord:
Synonyms: ; Il6; IL-6; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; Hepatocyte-Stimulating Factor; IL6; Hybridoma Growth Factor; MGI-2; Myeloid Differentiation-Inducing Protein; Plasmacytoma Growth Factor; BSF-2; IFN-beta 2; Arbitrary concentration; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Ql; Ordinal; QL; Qualitative; Qual; Screen; IL; Chemistry
ru-RU Russian (Russian Federation) Интерлейкин 6:PrThr:ТчкВрм:Сыв/Плаз:Пор:
Synonyms: Плазма Порядковый Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) İnterlökin 6:MevcEşik:Zmlı:Ser/Plaz:Srl:
Synonyms: Mevcut
zh-CN Chinese (China) 白细胞介素 6:存在情况或阈值:时间点:血清/血浆:序数型:
Synonyms: B 细胞分化因子-2;B 细胞刺激因子-2;BSF-2;B-细胞分化因子-2;B-细胞刺激因子-2;IFN-beta 2;IFN-β2;Il6;IL-6;MGI-2;杂交瘤生长因子;浆细胞瘤生长因子;白介素 6;白介素-6;白细胞介素-6;肝细胞刺激因子;髓系分化诱导因子 IL 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 白介 白介素 白细胞介素（Interleukin，白介素，IL） 血清或血浆

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=44322-6