LOINC
Version 2.73

44604-7Kappa light chains.free [Presence] in Urine by ImmunofixationActive

Part Descriptions

LP29081-4   Immunoglobulin light chains.kappa.free
Healthy patients have the majority of light chains in serum bound to heavy chains. Low levels of free light chains (unbound) are normal due to the over-production and secretion of free light chains by plasma cells. In the kidneys, the free light chains are selectively reabsorbed by the tubular cells, so their presence in urine is likely due to secretion into the urinary tract. Elevation of monoclonal free light chains in serum or urine signal malignant plasma cell proliferation (multiple myeloma), primary amyloidosis, or light chain deposition disease. Elevation of polyclonal free light chains suggests autoimmune diseases such as systemic lupus erythematosus. (Information from Freelite Beckman Coulter IMMAGE II package insert, Version 23, Feb 2009) Source: Regenstrief Institute

LP6336-4   Immunofixation
Plasma or concentrated urine is deposited on a gel. With an electrical current the proteins are sorted in function of their size, after which antigens for each targeted type of immunoglobulin are deposited on the gel. Thus more or less narrow bands appear on the gel, marking the location of the various immunoglobulines.
Immunofixation tends to replace protein electrophoresis because:

• it is faster (results within three hours);
• it is somewhat more sensitive. Immunofixation may reveal an immunoglobulin missed out by protein electrophoresis, especially at low concentrations (less than 1 gram/litre);
• it can be partially automated and can be used in more laboratories;
• it is more easily read and interpreted.

Immunofixation is however only sensitive to immunoglobulins and is more expensive than protein electrophoresis. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Immunofixation

Fully-Specified Name

Component
Immunoglobulin light chains.kappa.free
Property
PrThr
Time
Pt
System
Urine
Scale
Ord
Method
Immunofixation

Additional Names

Short Name
Kappa LC Free Ur Ql IFE
Display Name
Immunoglobulin light chains.kappa.free Immunofixation Ql (U)
Consumer Name Alpha
Free kappa light chains, Urine

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.17
Last Updated
Version 2.63
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016. Changed the LCN from 'Immunoglobulin light chains.kappa.free' to ' Kappa light chains.free' for readability.
Order vs. Observation
Observation

Member of these Groups

LG16698-9 Immunoglobulin light chains.kappa.free|PrThr|Pt|ANYUrine
LG36221-6 Immunoglobulin light chains.kappa.free|PrThr|Urine

Language Variants Get Info

zh-CNChinese (China)
免疫球蛋白轻链.Kappa 型.游离型:存在情况或阈值:时间点:尿液:序数型:免疫固定电泳分析法
nl-NLDutch (Netherlands)
immunoglobuline lichte ketens.kappa.vrij:aanwezigheid:moment:urine:ordinaal:immunofixatie
et-EEEstonian (Estonia)
Immuunglobuliinide kerged kapaahelad:PrThr:Pt:U:Ord:Immuunfiksatsioon
fr-BEFrench (Belgium)
Chaîne légère des immunoglobulines.kappa.libre:PrThr:Temps ponctuel:Urine:Ordinal:Immunofixation
fr-CAFrench (Canada)
Chaîne légère des immunoglobulines.kappa.libre:Présence-Seuil:Temps ponctuel:Urine:Ordinal:Immunofixation
fr-FRFrench (France)
Immunoglobuline chaines légères libres kappa:Présence/Seuil:Ponctuel:Urine:Qualitatif:Immunofixation
it-ITItalian (Italy)
Immunoglobuline, catene leggere.kappa.libere:PrThr:Pt:Urine:Ord:Immunofissazione
pt-BRPortuguese (Brazil)
Imunoglobulinas cadeias leves.kappa.livre:ACnc:Pt:Urina:Ord:Imunofixação
ru-RURussian (Russian Federation)
Иммуноглобулин легкие цепи.каппа.свободные:PrThr:ТчкВрм:Моча:Пор:Иммунофиксация
es-MXSpanish (Mexico)
Cadenas ligeras de inmunoglobulina kappa.libre:Presencia o umbral:Punto temporal:Orina:Ordinal:Inmunofijación
es-ESSpanish (Spain)
Cadenas ligeras kappa libres:PrThr:Punto temporal:Orina:Ord:Inmunofijación
tr-TRTurkish (Turkey)
İmmünglobulin hafif zincirler.kappa.serb:MevcEşik:Zmlı:İdrar:Srl:İmmünfiksasyon

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=44604-7