46125-1
Cardiolipin Ab [Presence] in Serum by Immunoassay
Active
Part Descriptions
LP14126-4 Cardiolipin
Cardiolipin (bisphosphatidyl glycerol) is an important component of the inner mitochondrial membrane, where it constitutes about 20% of the total lipid. It is typically present in metabolically active cells of the heart and skeletal muscle. It has also been observed in certain bacterial membranes. It serves as an insulator and stabilizes the activity of protein complexes important to the electron transport chain. Cardiolipin is a double phospholipid because it has four fatty acid tails, instead of the usual two. Barth syndrome, a rare genetic disorder, is a mutation in the gene coding for tafazzin, an enzyme involved in the biosynthesis of cardiolipin. Females heterozygous for the trait are not affected. Individuals with this condition have abnormal mitochondria and they cannot sustain adequate production of ATP. Cardiomyopathy and general weakness are common to these patients.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia
, Cardiolipin (Wikipedia)
LP21333-7 Cardiolipin Ab
Anti-cardiolipin antibodies (ACA) are antibodies often directed against cardiolipin and found in several diseases including syphilis, antiphospholipid syndrome, livedoid vasculitis, vertebrobasilar insufficiency, Behçet's syndrome, idiopathic spontaneous abortion, and systemic lupus erythematosus(SLE). They are a form of anti-mitochondrial antibody. In SLE, The anti-DNA antibodies and anti-cardiolipin act independently. In rheumatoid arthritis with systemic sclerosis (scleroderma) these antibodies may tie two conditions together.
Anti-cardiolipin antibodies can be classified in two ways:
As IgM, IgG or IgA
As β2-glycoprotein dependent or independent
In autoimmune disease ACA are beta-2 glycoprotein dependent
syphilis ACA are beta-2 glycoprotein independent and can be assayed using the VDRL test
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia
, Wikipedia
Fully-Specified Name
- Component
- Cardiolipin Ab
- Property
- PrThr
- Time
- Pt
- System
- Ser
- Scale
- Ord
- Method
- IA
Additional Names
- Long Common Name
- Cardiolipin Ab [Presence] in Serum by Immunoassay
- Short Name
- Cardiolipin Ab Ser Ql IA
- Display Name
- Cardiolipin Ab IA Ql (S)
- Consumer Name Alpha Get Info
- Cardiolipin antibody, Blood
Basic Attributes
- Class
- COAG
- Type
- Laboratory
- First Released
- Version 2.17
- Last Updated
- Version 2.73 (MIN)
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 5250
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Καρδιολιπίνη Αντίσωμα: Synonyms: PrThr Καρδιολιπίνη |
| es-ES | Spanish (Spain) | Cardiolipinas Anticuerpos: |
| es-MX | Spanish (Mexico) | Cardiolipin Ab: |
| et-EE | Estonian (Estonia) | Kardiolipiin antikehad: Synonyms: Järgarvuline Juhuslik Seerum |
| fr-CA | French (Canada) | Cardiolipine, Ac: |
| fr-FR | French (France) | Cardiolipine anticorps: |
| fr-BE | French (Belgium) | Cardiolipine Ac: Synonyms: Anticorps |
| it-IT | Italian (Italy) | Cardiolipina Ab: Synonyms: anticorpo Immunoassay Presenza o Soglia Punto nel tempo (episodio) Siero Studio di coagulazione |
| nl-NL | Dutch (Netherlands) | cardiolipine As: Synonyms: antistof; |
| pt-BR | Portuguese (Brazil) | Cardiolipina Ac: Synonyms: ACA; |
| ru-RU | Russian (Russian Federation) | Кардиолипин Ат: Synonyms: Антитело Порядковый Сыворотка Точка во времени; |
| tr-TR | Turkish (Turkey) | Kardiyolipin Ab: Synonyms: İmmünölçüm, immünoassay Mevcut |
| zh-CN | Chinese (China) | 心磷脂 抗体: Synonyms: Ab; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=46125-1
LOINC Copyright
Copyright © 2025 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://