46244-0
Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation identified by Molecular method
Active
Term Description
Mycobacterium rpoB region gene mutation for Rifampim resistance
Source: Regenstrief LOINC
Part Description
LP267160-2 Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation
Rifampicin (RIF) is a first line drug used to treat Mycobacterium tuberculosis (TB). It inhibits transcription by binding with the rpoB encoded beta-subunit of the DNA-dependent RNA polymerase (RNAP). The majority of the mutations across bacterial species occurs in the 81 bp region of cluster, also known as the rifampicin resistance determining region (RRDR). The RRDR is surrounded by 12 amino acids, 11 of which have been linked to RIF mutations. The mutations in the RRDR usually result in an amino acid substitution that has an associated compact side chain with a larger amino acid and compact side chain. The inflexibility of rifampicin prevents it from being able to bind to the mutated beta subunit of RNAP. PMID: 26038512
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation identified
- Property
- Prid
- Time
- Pt
- System
- Isolate/Specimen
- Scale
- Nom
- Method
- Molgen
Additional Names
- Short Name
- MTB cmplx rpoB RIF mut Islt/Spm
- Display Name
- M. tuberculosis complex rpoB gene rifAMPin resistance mutation identified Molgen Nom (Islt/Spec)
- Consumer Name Alpha Get Info
- Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation test
Basic Attributes
- Class
- ABXBACT
- Type
- Laboratory
- First Released
- Version 2.19
- Last Updated
- Version 2.67
- Change Reason
- Release 2.67: COMPONENT: Updated Component to reflect that rpoB is a native gene in which a mutation causes rifampin resistance [Approved by LOINC Laboratory Committee in June 2018].; METHOD_TYP: Update Method from "Probe.amp.tar" according to the new sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].; SYSTEM: Updated System from "Isolate" according to the new sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].
- Order vs. Observation
- Observation
Member of these Panels
LOINC | Long Common Name |
---|---|
89876-7 | MTB complex rifAMPin and isoniazid resistance panel by Molecular genetics method |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
de-DE | German (Germany) | Mycobacterium tuberculosis-Komplex rpoB-Gen Rifampicin-Resistenz-Mutation identifiziert: |
es-ES | Spanish (Spain) | Mutación Gen rpoB de resistencia a rifampicina de Mycobacterium tuberculosis identificado: |
es-MX | Spanish (Mexico) | Se identificó una mutación de resistencia a rifAMPina del complejo de Mycobacterium tuberculosis rpoB: |
fr-FR | French (France) | Mycobacterium complexe tuberculosis résistance à la rifampicine rpoB gène mutation identifiée: |
fr-CA | French (Canada) | Mycobacterium complexe tuberculosis résistance à la rifampicine rpoB gène mutation, Identifiés: Synonyms: #REF! |
it-IT | Italian (Italy) | Mycobacterium tuberculosis complex, gene rpoB rifampina resistente, identificato: Synonyms: Complesso di micobatteri della tubercolosi Gene rpoB di complesso di micobatteri della tuberc Genetica molecolare Isolato o Campione Micobatterio della tubercolosi Presenza o Identità Punto nel tempo (episodio) Suscettibilità agli antibiotici |
nl-NL | Dutch (Netherlands) | Mycobacterium tuberculosis complex rpoB-gen rifampicineresistentie-mutatie geïdentificeerd: Synonyms: isolaat/specimen molgen |
pt-BR | Portuguese (Brazil) | Mycobacterium tuberculosis DNA.rpoB: Synonyms: ; |
zh-CN | Chinese (China) | 结核分枝杆菌复合菌群 rpoB 基因利福平耐药性突变 已鉴定的: Synonyms: AFB RIF; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=46244-0
LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright