Version 2.77

Term Description

Mycobacterium rpoB region gene mutation for Rifampim resistance
Source: Regenstrief LOINC

Part Description

LP267160-2   Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation
Rifampicin (RIF) is a first line drug used to treat Mycobacterium tuberculosis (TB). It inhibits transcription by binding with the rpoB encoded beta-subunit of the DNA-dependent RNA polymerase (RNAP). The majority of the mutations across bacterial species occurs in the 81 bp region of cluster, also known as the rifampicin resistance determining region (RRDR). The RRDR is surrounded by 12 amino acids, 11 of which have been linked to RIF mutations. The mutations in the RRDR usually result in an amino acid substitution that has an associated compact side chain with a larger amino acid and compact side chain. The inflexibility of rifampicin prevents it from being able to bind to the mutated beta subunit of RNAP. PMID: 26038512 Source: Regenstrief LOINC

Fully-Specified Name

Component
Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation identified
Property
Prid
Time
Pt
System
Isolate/Specimen
Scale
Nom
Method
Molgen

Additional Names

Short Name
MTB cmplx rpoB RIF mut Islt/Spm
Display Name
M. tuberculosis complex rpoB gene rifAMPin resistance mutation identified Molgen Nom (Islt/Spec)
Consumer Name Alpha Get Info
Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation test

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.19
Last Updated
Version 2.67
Change Reason
Release 2.67: COMPONENT: Updated Component to reflect that rpoB is a native gene in which a mutation causes rifampin resistance [Approved by LOINC Laboratory Committee in June 2018].; METHOD_TYP: Update Method from "Probe.amp.tar" according to the new sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].; SYSTEM: Updated System from "Isolate" according to the new sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
89876-7 MTB complex rifAMPin and isoniazid resistance panel by Molecular genetics method

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Mycobacterium tuberculosis-Komplex rpoB-Gen Rifampicin-Resistenz-Mutation identifiziert:Nachweis oder Identität:Zeitpunkt:Isolat oder Probenmaterial:Nominal:Molekulargenetisch
es-ES Spanish (Spain) Mutación Gen rpoB de resistencia a rifampicina de Mycobacterium tuberculosis identificado:Presencia o identidad:Punto temporal:Muestra aislada:Nom:Genética molecular
es-MX Spanish (Mexico) Se identificó una mutación de resistencia a rifAMPina del complejo de Mycobacterium tuberculosis rpoB:Presencia o identidad:Punto temporal:Aislado o espécimen:Nominal:Genética molecular
fr-FR French (France) Mycobacterium complexe tuberculosis résistance à la rifampicine rpoB gène mutation identifiée:Identification:Ponctuel:Isolat/échantillon:Résultat nominal:Biologie moléculaire
fr-CA French (Canada) Mycobacterium complexe tuberculosis résistance à la rifampicine rpoB gène mutation , Identifiés:Présence ou identité:Temps ponctuel:Isolat/Échantillon:Nominal:Molgen
it-IT Italian (Italy) Mycobacterium tuberculosis complex, gene rpoB rifampina resistente , identificato:Prid:Pt:Isolato/Campione:Nom:Molgen
Synonyms: Complesso di micobatteri della tubercolosi Gene rpoB di complesso di micobatteri della tuberc Genetica molecolare Isolato o Campione Micobatterio della tubercolosi Presenza o Identità Punto nel tempo (episodio) Suscettibilità agli antibiotici
nl-NL Dutch (Netherlands) Mycobacterium tuberculosis complex rpoB-gen rifampicineresistentie-mutatie geïdentificeerd:identificator:moment:isolaat of monster:nominaal:moleculair genetisch onderzoek
Synonyms: isolaat/specimen molgen
pt-BR Portuguese (Brazil) Mycobacterium tuberculosis DNA.rpoB:Ident:Pt:Isolado:Nom:Sonda com limite de detecção da amplificação de alvo
Synonyms: ; TB; M TB rpoB; Mycobacterium tuberculosum; M tuberculosis; Mtb; Deoxyribonucleic acid; Identity or presence; Point in time; Random; Islt; Isol; Nominal; PCR; Polymerase chain reaction; Transcription mediated amplification; NASBA; Nucleic acid sequence based analysis; SDA; Strand Displacement Amplification; LAT; Ligation-activated transcription; 3SR SR; 3 Self-Sustaining Sequence Replication; LCR; Ligase chain reaction; QBR; Q-Beta Replicase or probe amplification category method; Probe with target amplification; NAAT; TMA; Amp Prb; Probe with ampification; DNA probe; Amplified; Acid Fast Bacilli; Mycobact; Myco; AFB; Acid fast bacillus; ANTIBIOTIC SUSCEPTIBILITIES
zh-CN Chinese (China) 结核分枝杆菌复合菌群 rpoB 基因利福平耐药性突变 已鉴定的:存在与否或特征标识:时间点:分离株/标本:名义型:分子遗传学类实验室方法
Synonyms: AFB RIF;甲哌力复霉素 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分支杆菌 分支杆菌属 分枝杆菌属 分离出的;分离的;已分离的;检出的;经分离的;经过分离的;经过鉴定的;经鉴定的;鉴定的 分离株/标本（样本、样品、试样） 分离物;分离菌;分离菌株;隔离种群 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 劳瘵 受检物 复合体 存在;存在与否;特征标识;身份;身份标识 抗力 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 抗耐性 抗酸 抗酸杆菌 抗酸杆菌（Acid fast bacillus，AFB） 抗酸菌 抵抗力 抵抗性 时刻;随机;随意;瞬间 样品 样本 电阻 痨 痨病 结核 结核;肺结核;痨;痨病;TB 结核分支杆菌;结核杆菌;结核菌 结核分枝杆菌复合菌群（复合群、复合菌、复合体、复合物）;结核分支杆菌复合体;结核分支杆菌复合群;结核分支杆菌复合菌群;结核分枝杆菌复合体;结核分枝杆菌复合物;结核分枝杆菌结核菌群;结核杆菌复合菌群 结核分枝杆菌复合菌群（结核分支杆菌复合体、结核分支杆菌复合群、结核分支杆菌复合菌群、结核分枝杆菌复合体、结核分枝杆菌复合物、结核分枝杆菌结核菌群、结核杆菌复合菌群）基因利福平（甲哌力复霉素、利福霉素、立复霉素、立放平）耐药性（抗性、耐性、耐药、抗药、抗药性、耐受、耐药型）突变 结核病 耐性 肺结核 试样 遗传基因;遗传因子;吉恩;生物基因 阻力

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