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Part Description

LP39188-5   Aquaporin 4 water channel Ab.IgG
The water channel aquaporin 4 (AQP4) receptor regulates the water homeostasis in the central nervous system (CNS). Autoantibodies to the AQP4 receptor bind to the receptor and cause neuromyelitis optica (NMO) which is an idiopathic, severe, demyelinating disease of the CNS that primarily affects the optic nerve and spinal cord. Before the discovery of the AQP4 receptor antibody NMO was often misdiagnosed as a variant of multiple sclerosis (MS). With improved clinical laboratory tests and distinct immunological and pathological attributes the two diseases are less often confused. Distinguishing MS and NMO is especially important because they have different treatments. Treatment for NMO includes corticosteroids and plasmapheresis; typical medications used to treat MS, such as beta-interferon and glatiramer acetate are not effective against NMO. During the disease process, the aquaporin 4 receptor antibody binds to the aquaporin 4 receptor initiating the activation of complement, inflammatory demyelination and necrosis. Eighty to ninety percent of patients with NMO experience recurrent episodes of optic neuritis and myelitis. Many patients with NMO also have other autoimmune diseases including thyroiditis, systemic lupus erythematosus
and Sjogren's syndrome. PMID: 17706564 Detection of APQ4-IgG is indicative of a relapsing disease. Immediate treatment with immunosuppressive drugs reduces the frequency and disability of future attacks. http://labmed.ucsf.edu/labmanual/db/dataall/tests/1424.html Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Aquaporin 4 water channel Ab.IgG:PrThr:Pt:CSF:Ord:
Long Common Name
Aquaporin 4 water channel IgG Ab [Presence] in Cerebrospinal Fluid
Short Name
AQP4 H2O channel IgG CSF Ql
Display Name
Aquaporin 4 water channel IgG Ql (CSF)
Consumer Name Alpha Get Info
Aquaporin 4 water channel IgG antibody, Spinal fluid

Part Model Get Info

  • Component
    Aquaporin 4 water channel Ab.IgG
    LP39188-5
    • Analyte
      Aquaporin 4 water channel Ab.IgG
      LP39188-5
      • Component Numerator
        Aquaporin 4 water channel Ab.IgG
        LP39188-5
        • Component Numerator Core
          Aquaporin 4 water channel
          LP102619-6
        • Component Numerator Core Suffix
          Ab.IgG
          LP32401-9
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    CSF
    LP7156-5
    • System Core
      CSF
      LP7156-5
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    NULL
     

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.19
Last Updated
Version 2.83 (MIN)
Change Reason
Release 2.67: COMPONENT: Updated "receptor" to "water channel" per current scientific nomenclature; Previous Releases: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both
Common Test Rank Get Info
8092

Member of these Panels

LOINCLong Common Name
94353-0Myelopathy autoimmune Ab panel - Cerebrospinal Fluid
101416-6Pediatric autoimmune central nervous system disorders evaluation panel - Cerebrospinal Fluid
101417-4Pediatric autoimmune central nervous system disorders evaluation panel - Serum or Plasma

Member of these Groups Get Info

LOINC GroupGroup Name
LG50124-3Aquaporin 4 water channel Ab.IgG|PrThr|Pt|CSF

Language Variants Get Info

TagLanguageTranslation
ar-JOArabic (Jordan)الكشف عن تواجد أضداد الغلوبولين المناعي نمط G للأكوابورين 4 في القناة المائية
Synonyms: الكشف عن تواجد أضداد الغلوبولين المناعي نمط G للأكوابورين 4 في القناة المائية
cs-CZCzech (Czechia)Akvaporin 4 IgG:Přítomnost nebo práh:Časový bod:Mozkomíšní mok:Ordinální:
de-ATGerman (Austria)Synonyms: Aquaporin-4-Antikörper IgG ql. /L
el-GRGreek (Greece)Δίαυλος ύδατος ακουαπορίνης 4 Αντισώματα IgG:PrThr:Pt:ΕΝΥ:Ord:
Synonyms: Ord PrThr Pt SERO Ανοσοσφαιρίνη G Αντίσωμα Αντισώματα IgG Δίαυλος ύδατος ακουαπορίνης 4 ΕΝΥ Νερό
es-ESSpanish (Spain)Receptor de Acuaporina 4 IgG:PrThr:Punto temporal:Líquido Cefalorraquideo:Ord:
es-MXSpanish (Mexico)Acuaporina 4 canal de agua Ab.IgG:Presencia o umbral:Punto temporal:Fluído espinal cerebral:Ordinal:
et-EEEstonian (Estonia)Akvaporiin 4 retseptor antikehad.IgG:PrThr:Pt:CSF:Ord:
Synonyms: Immuunglobuliin G Järgarvuline Juhuslik Liikvor
fr-CAFrench (Canada)Canal de l'eau Aquaporin 4, IgG:Présence-Seuil:Temps ponctuel:LCR:Ordinal:
fr-FRFrench (France)Aquaporine 4 récepteur Ac IgG:Présence/Seuil:Ponctuel:Liquide céphalorachidien:Qualitatif:
fr-BEFrench (Belgium)Récepteur Aquaporin 4 Anticorps. IgG:PrThr:Temps ponctuel:LCR:Ordinal:
Synonyms: Anticorps
it-ITItalian (Italy)Acquaporina 4, canale idrico Ab.IgG:PrThr:Pt:LCS:Ord:
Synonyms: anticorpi IgG anticorpo Canale idrico dell''acquaporina 4 Liquido cerebrospinale Presenza o Soglia Punto nel tempo (episodio) Sierologia (anticorpi e la maggior parte degli ant
nl-NLDutch (Netherlands)aquaporine 4 waterkanaal As.IgG:aanwezigheid:moment:liquor cerebrospinalis:ordinaal:
Synonyms: antistof; antilichaam
pt-BRPortuguese (Brazil)Neuromyelitis optica Ac.IgG:ACnc:Pt:LCR:Ord:
Synonyms: ; NMO; Devic's disease; Immune globulin G; Immunoglobulin G; Arbitrary concentration; Point in time; Random; Cerebral spinal fluid; Spinal Fluid; Cerebrospinal Fl; Spinal Flu; Spinal Fld; Ql; Ordinal; QL; Qualitative; Qual; Screen; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; Serology
ru-RURussian (Russian Federation)Аквапорина 4 рецепторы Ат.IgG:PrThr:ТчкВрм:ЦСЖ:Пор:
Synonyms: Антитело Порядковый Точка во времени;Момент Цереброспинальная жидкость
tr-TRTurkish (Turkey)Akuaporin 4 reseptörü Ab.IgG:MevcEşik:Zmlı:BOS:Srl:
Synonyms: Ak Ak.IgG Mevcut
uk-UAUkrainian (Ukraine)Аквапорин-4 водний канал Антитіла. IgG:Наявність або Поріг:МоментЧасу:Спинномозкова рідина:Порядково:
Synonyms: ABS; Aby; Antby; Anti; Antibodies; Antibody; AQP4; AQP4 H2O channel; Autoantibodies; Autoantibody; Cerebral spinal fluid; Cerebrospinal Fl; Devic's disease; Immune globulin G; Immunoglobulin G; Neuromyelitis optica; NMO; NMO spectrum disorders; NMOSD; Opticospinal multiple sclerosis; Ordinal; Point in time; PR; QL; Qual; Qualitative; Random; Screen; Serology; Spinal Fl; Spinal Fld; Spinal Flu; Spinal Fluid; Water channel aquaporin-4
zh-CNChinese (China)水通道蛋白 4 受体 抗体.IgG:存在情况或阈值:时间点:脑脊液:序数型:
Synonyms: Ab.IgG;IgG;抗体 IgG Ab;自身抗体 CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 Devic 氏综合征 IgG Devic 综合征 IgG Devic氏综合征 Ab.IgG Devic氏综合征抗体.IgG Devic综合征 Ab.IgG Devic综合征抗体.IgG H2O NMO Ab.IgG NMO 抗体.IgG 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫球蛋白 G 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 脊液 脊髓液 脑脊液（Cerebral spinal fluid，CSF） 脑脊髓液 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类 视神经脊髓炎 Ab.IgG 视神经脊髓炎 IgG

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=46718-3