46724-1

CYP2C9 gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal

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Term Description

The patient's allelic genotype (e.g. *1/*8) for the CYP2C9 gene allele. Testing may include the most common alleles of CYP2C9, such as *2, *6,*8,*11,*13,*15. The example answers provided with this code are a small representative of the CYP2C9 allelic genotypes. For a complete list of CYP2C9 alleles, see the The Human Cytochrome P450 (CYP) Allele Nomenclature Database (http://www.cypalleles.ki.se).
Source: Regenstrief LOINC

Part Description

LP417568-5 CYP2C9 gene allele
Cytochrome P450-2C9 (CYP2C9; [HGNC Gene ID: 2623]), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism 10-15% of drugs in current clinical use. Genetic variations in CYP2C9 can affect the response (i.e., efficacy or toxicity) to drugs metabolized by CYP2C9 and selection of alternative dosing or agents may be necessary in individuals with specific CYP2C9 genetic variations. PMID: 25099164 PMID: 21900891 See https://www.pharmgkb.org/gene/PA126 for more information and dosing guidelines for drugs impacted by CYP2C9 genetic variation. Source: Clinical Pharmacogenetics Implementation Consortium

Fully-Specified Name

Component: CYP2C9 gene allele
Property: Geno
Time: Pt
System: Bld/Tiss
Scale: Nom
Method: Molgen

Additional Names

Short Name: CYP2C9 allele Geno Bld/T
Display Name: CYP2C9 gene allele genotype Molgen (Bld/Tiss)
Consumer Name Alpha Get Info: CYP2C9 gene allele genotype, Blood or tissue specimen

Example Answer List: LL5510-4

Source: Regenstrief LOINC

Answer	Code	Score	Answer ID
CYP2C9 1/2			LA30670-6
CYP2C9 1/6			LA30671-4
CYP2C9 6/11			LA30672-2

Basic Attributes

Class: MOLPATH.PHARMG
Type: Laboratory
First Released: Version 2.19
Last Updated: Version 2.73
Change Reason: Release 2.68: CLASS: Updated to MOLPATH.PHARMG, the more representative LOINC Class for this concept.; COMPONENT: Updated Component to align with the LOINC term naming model for concepts used to report allelic genotypes (e.g. CYP2C9*1/*8), which was the original intent for this term.; Release 2.67: CLASS: Updated to MOLPATH.PHARMG, the more representative LOINC Class for this concept.; Previous Releases: Based on LOINC Committee review (June 2016), "targeted" was added to the Component to clarify that this test is looking for a specific set of mutations as described in the LOINC User Guide under the Molecular Genetics section.
Order vs. Observation: Both
Common Test Rank Get Info: 9570

Member of these Panels

LOINC	Long Common Name
54450-2	CYP2C9 and VKORC1 panel - Blood or Tissue by Molecular genetics method
93196-4	Warfarin response genotype panel - Blood or Tissue by Molecular genetics method

Language Variants Get Info

Tag	Language	Translation
de-AT	German (Austria)	Synonyms: CYP2C9 Genotyp.
es-ES	Spanish (Spain)	Alelo del gen CYP2C9:Genotipo:Punto temporal:Sangre o tejido:Nom:Genética molecular
es-MX	Spanish (Mexico)	Alelo del gen CYP2C9:Genotipo:Punto temporal:Sangre o tejido:Nominal:Genética molecular
fr-FR	French (France)	CYP2C9 gène allèle:Génotype:Ponctuel:Sang/Tissu:Résultat nominal:Biologie moléculaire
it-IT	Italian (Italy)	CYP2C9, gene allele:Geno:Pt:Sangue/Tess:Nom:Molgen Synonyms: Farmacogenomica Gene CYP2C9 Genetica molecolare Genotipo Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL	Dutch (Netherlands)	CYP2C9-allel:genotype:moment:bloed of weefsel:nominaal:moleculair genetisch onderzoek Synonyms: CYP2C9 gen molgen
pt-BR	Portuguese (Brazil)	CYP2C9 análise de mutação genética:Ident:Pt:Sg/Tecido:Nom:Genética molecular Synonyms: Cytochrome P450 2C9 Genotyping; CPC9; CYP2C; CYP2C10; CYPIIC9; Identity or presence; Point in time; Random; Bld/T; Tissue; Bld/T; Blood; WB; Whole blood; Nominal; PCR; Molecular genetics; Mut Anal; Mutations; MOLPATH.MUTATIONS; MOLPATH.MUTATIONS; Molecular pathology
zh-CN	Chinese (China)	CYP2C9 基因等位基因:基因型:时间点:全血/组织:名义型:分子遗传学类实验室方法 Synonyms: CPC9;CYP2C;CYP2C10;CYPIIC9;细胞色素 P450 2C9 基因分型;细胞色素 P450 2C9 基因型分析;细胞色素 P450 2C9 基因型鉴定全血或组织;血液/组织;血液或组织分子病理学;分子病理学试验分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答时刻;随机;随意;瞬间未作说明的组织;组织;组织 & 涂片血;血液遗传基因;遗传因子;吉恩;生物基因

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