Version 2.77

Part Description

LP18633-5   Coproporphyrin 1
Coproporhyrin I is a porphyrin metabolite arising from heme synthesis. Porphyrins are pigments found in both animal and plant life. Coproporphyrin I is a tetrapyrrole dead-end product from the spontaneous oxidation of the methylene bridges of coproporphynogen, arising from heme synthesis and secreted in feces and urine. Increased levels of coproporphyrins can indicate congenital erythropoietic porphyria or sideroblastic anaemia. Porphyria is a pathological state characterised by abnormalities of porphyrin metabolism and results in the excretion of large quantities of porphyrins in the urine and in extreme sensitivity to light. A large number of factors are capable of increasing porphyrin excretion, owing to different and multiple causes and etiologies: 1) the main site of the chronic hepatic porphyria disease process concentrates on the liver, 2) a functional and morphologic liver injury is almost regularly associated with this chronic porphyria, 3) the toxic form due to occupational and environmental exposure takes mainly a subclinical course. Hepatic factors includes disturbance in coproporphyrinogen metabolism, which results from inhibition of coproporphyrinogen oxidase as well as from the rapid loss from, and diminished utilization of coproporphyrinogen in the hepatocytes, which may also explain why coproporphyrin, its autoxidation product, predominates physiologically in the urine; decreased biliary excretion of coproporphyrin leading to a compensatory urinary excretion, so that the coproporphyrin ring isomer ratio (1:III) becomes a sensitive index for impaired liver function and intrahepatic cholestasis; and disturbed activity of hepatic uroporphyrinogen decarboxylase. In itself, secondary coproporphyrinuria is not associated with porphyria symptoms of a hepatologic-gastroenterologic, neurologic, or dermatologic order, even though coproporphyrinuria can occur with such symptoms. PMID: 3327428 Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Corproporphyrin I

Fully-Specified Name

Component
Coproporphyrin 1
Property
MCnc
Time
24H
System
Urine
Scale
Qn
Method

Additional Names

Short Name
Copro1 24h Ur-mCnc
Display Name
Coproporphyrin 1 (24H U) [Mass/Vol]
Consumer Name Alpha Get Info
Coproporphyrin 1, Urine

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.19
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
6997

Member of these Groups Get Info

LOINC Group Group Name
LG36351-1 Coproporphyrin 1|MCnc|Urine

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Coproporphyrin 1:Massenkonzentration:24 Stunden:Urin:Quantitativ:
es-ES Spanish (Spain) Coproporfirina 1:Concentración de masa:24 horas:Orina:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Coproporfirina 1:Concentración de masa:24H:Orina:Cuantitativo:
et-EE Estonian (Estonia) Koproporfüriin 1:MCnc:24 tunni:U:Qn:
Synonyms: Kvantitatiivne Uriin
fr-CA French (Canada) Coproporphyrine 1:Concentration de masse:24 h:Urine:Quantitatif:
fr-FR French (France) Coproporphyrine 1:Masse/Volume:24H:Urine:Numérique:
fr-BE French (Belgium) Coproporphyrine 1:Concentration de masse:24 h:Urine:Quantitatif:
it-IT Italian (Italy) Coproporfirina 1:MCnc:24h:Urine:Qn:
Synonyms: 24 Ore Chimica Concentrazione di Massa
nl-NL Dutch (Netherlands) coproporfyrine 1:massa/volume:24 uur:urine:kwantitatief:
Synonyms: 24U
pt-BR Portuguese (Brazil) Coproporfirina 1:MCnc:24H:Urina:Qn:
Synonyms: ; Copro1; Coproporphyrin I; Coproporphyrins; Copro; Tetracarboxyporphyrin; Coproporph; Tetracarboxyl porphyrin; Tetracarboxylporphyrin; Tetracarboxylporphyrins; Mass concentration; Level; 1 day; 24 hours; 24HR; Ur; UR; Urn; UA; Quantitative; QNT; Quant; Quan; Chemistry
ru-RU Russian (Russian Federation) Копропорфирин 1:МассКонц:24 часа:Моча:Колич:
Synonyms: Количественный Массовая концентрация
tr-TR Turkish (Turkey) Koproporfirin 1:KütlKons:24Sa:İdrar:Kant:
zh-CN Chinese (China) 粪卟啉 I:质量浓度:24小时:尿液:定量型:
Synonyms: 1天;1日;24.0小时;一天;一日;二十四个小时;二十四小时 Ⅰ Copro;Coproporph;四羧基卟啉 Copro1;粪卟啉 1;粪卟啉Ⅰ I 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 尿;小便;下泉 水平;浓度;质量浓度(单位体积)

Example Units

Unit Source
ng/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=47253-0