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Part Description

LP15841-7   Purine nucleoside phosphorylase
Purine nucleoside phosphorylase (also known as PNPase) is an enzyme (EC 2.4.2.1) involved in purine metabolism. PNP metabolizes adenosine into adenine, inosine into hypoxanthine, and guanosine into guanine, in each case creating ribose phosphate. NP encodes the enzyme purine nucleoside phosphorylase that, together with adenosine deaminase (ADA), serves a key role in purine catabolism, referred to as the salvage pathway. Mutations in ADA lead to an accumulation of (d)ATP, which inhibits ribonucleotide reductase, leading to a deficiency in (d)CTPs and (d)TTPs, which, in turn, induces apoptosis in T-lymphocytes and B-lymphocytes, leading to severe combined immunodeficiency (SCID).

PNP-deficient patients will have an immunodeficiency problem. It affects only T-cells; B-cells are unaffected by the deficiency. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LOINC Names Get Info

Fully-Specified Name
Purine nucleoside phosphorylase:CCnt:Pt:RBC:Qn:
Long Common Name
Purine nucleoside phosphorylase [Enzymatic activity/mass] in Red Blood Cells
Short Name
PNP RBC-cCnt
Display Name
Purine nucleoside phosphorylase (RBC) [Catalytic activity/Mass]
Consumer Name Alpha Get Info
Purine nucleoside phosphorylase, Red blood cells

Part Model Get Info

  • Component
    Purine nucleoside phosphorylase
    LP15841-7
    • Analyte
      Purine nucleoside phosphorylase
      LP15841-7
      • Component Numerator
        Purine nucleoside phosphorylase
        LP15841-7
        • Component Numerator Core
          Purine nucleoside phosphorylase
          LP15841-7
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    CCnt
    LP6790-2
  • Time
    Pt
    LP6960-1
  • System
    RBC
    LP7536-8
    • System Core
      RBC
      LP7536-8
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    NULL
     

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.21
Last Updated
Version 2.70 (MIN)
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Purin-nukleosidfosforyláza:Katalytický obsah:Časový bod:Erytrocyty:Kvantitativní:
el-GRGreek (Greece)Φωσφορυλάση πουρινικών νουκλεοσιδίων:CCnt:Pt:Ερυθρά αιμοσφαίρια:Qn:
Synonyms: CCnt CHEM Pt Qn Ερυθρά αιμοσφαίρια Πουρίνη Φωσφορυλάση Φωσφορυλάση πουρινικών νουκλεοσιδίων
es-MXSpanish (Mexico)Purina nucleósido fosforilasa:Contenido catalítico:Punto temporal:Eritrocitos:Cuantitativo:
es-ESSpanish (Spain)Purin nucleósido fosforilasa:Contenido catalítico:Punto temporal:Glóbulos rojos:Qn:
Synonyms: Cuantitativo
et-EEEstonian (Estonia)Puriini nukleosiidi fosforülaas:CCnt:Pt:RBC:Qn:
Synonyms: Erütrotsüüdid Juhuslik Kvantitatiivne
fr-CAFrench (Canada)Purine-nucléoside phosphorylase:Contenu catalytique:Temps ponctuel:GR:Quantitatif:
fr-FRFrench (France)Purine nucléoside phosphorylase:Catalytique/Masse:Ponctuel:Érythrocytes:Numérique:
fr-BEFrench (Belgium)Purine-nucléoside phosphorylase:Contenu catalytique:Temps ponctuel:GR:Quantitatif:
it-ITItalian (Italy)Purina nucleoside fosforilasi:CCnt:Pt:RBC:Qn:
Synonyms: Chimica Contenuto Catalitico Globuli rossi PNPasi Punto nel tempo (episodio)
nl-NLDutch (Netherlands)purinenucleosidefosforylase:enzymatische activiteit/massa:moment:erytrocyten:kwantitatief:
Synonyms: rode bloedcellen
pl-PLPolish (Poland)Fosforylaza nukleozydów purynowych:zawartość katalityczna:punkt w czasie:krwinki czerwone:ilościowy:
pt-BRPortuguese (Brazil)Purina nucleosídeo fosforilase:CCnt:Pt:Eritroc:Qn:
Synonyms: ; PNP; Catalytic Content; Point in time; Random; Erythrocytes; Red blood corpusles; Red blood cells; Quantitative; QNT; Quant; Quan; Chemistry
ru-RURussian (Russian Federation)Пуриновых нуклеозидов фосфорилаза:КаталСод:ТчкВрм:Эритроциты:Колич:
Synonyms: Каталитическое содержание Количественный Точка во времени;Момент
tr-TRTurkish (Turkey)Pürin nukleozid fosforilaz:Ktlİçrk:Zmlı:Eritrosit:Kant:
Synonyms: RBC
zh-CNChinese (China)嘌呤核苷酸磷酸化酶:催化含量:时间点:红细胞:定量型:
Synonyms: PNP RBC;RBCS;红血球;红血细胞;赤血球 催化含量(单位质量);单位质量的酶单位数 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 四氮杂茚 时刻;随机;随意;瞬间

Example Units

UnitSource
nmol/min/mg{Hb}Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=47740-6