48597-9
cycloSPORINE [Mass/volume] in Blood by Immunoassay --trough
Active
Part Descriptions
LP16098-3 cycloSPORINE
Cyclosporine (Brand names Neoral, Restasis, Sandimmune, Gengraf) is a cyclic undecapeptide of fungal origin and a potent calcineurin inhibitor immunosuppressive agent. The introduction of cyclosporine in human organ transplantation substantially improved patient and graft survival in patients receiving heart, kidney, liver, pancreas, lung or bone marrow transplants. Cyclosporine was the first drug to specifically and reversibly inhibit the activation and proliferation of lymphocytes. The main mechanism through which cyclosporine exerts its immunosuppressive effect is the inhibition of T cell activation and proliferation. Monitoring and concentration-controlled dosing is required to maintain patient drug levels within a narrow therapeutic window; low levels could cause transplant rejection and high levels may cause nephrotoxicity. PMID: 19545653
Source: Regenstrief LOINC
, PMID: 19545653
LP20176-1 trough
In medicine, a trough level is the lowest level that a medicine is present in the body. In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing. It should be contrasted with a "peak level", which is the highest level of the medicine in the body, and the "average level", which is the mean level over time. It helps in therapeutic drug monitoring. It is widely used in clinical trials for newer medicines for its therapeutic effectiveness and safety.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia
, Trough levels for therapeutic drug monitoring
Fully-Specified Name
- Component
- cycloSPORINE^trough
- Property
- MCnc
- Time
- Pt
- System
- Bld
- Scale
- Qn
- Method
- IA
Additional Names
- Long Common Name
- cycloSPORINE [Mass/volume] in Blood by Immunoassay --trough
- Short Name
- cycloSPORINE Trough Bld IA-mCnc
- Display Name
- cycloSPORINE trough IA (Bld) [Mass/Vol]
- Consumer Name Alpha Get Info
- cycloSPORINE trough, Blood
Basic Attributes
- Class
- DRUG/TOX
- Type
- Laboratory
- First Released
- Version 2.21
- Last Updated
- Version 2.73 (MIN)
- Change Reason
- The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 13314
Member of these Groups Get Info
LOINC Group | Group Name |
---|---|
LG19342-1 | Cyclosporine^trough| |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
el-GR | Greek (Greece) | Κυκλοσπορίνη^ελάχιστα επίπεδα: Synonyms: MCnc Κυκλοσπορίνη |
es-ES | Spanish (Spain) | Ciclosporina^Valle monitorización terapéutica de fármacos: Synonyms: Cuantitativo |
es-MX | Spanish (Mexico) | cicloesporino ^ canal: |
et-EE | Estonian (Estonia) | Tsüklosporiin^baas: Synonyms: Juhuslik Kvantitatiivne Veri |
fr-CA | French (Canada) | Cyclosporine^Creux: |
fr-FR | French (France) | Ciclosporine taux résiduel: |
fr-BE | French (Belgium) | Cyclosporine^Creux: Synonyms: Minimum, nadir |
it-IT | Italian (Italy) | Ciclosporina^valore minimo: Synonyms: Concentrazione di Massa Immunoassay Livelli farmacologici e tossicologia Punto nel tempo (episodio) Sangue valore minimo TDM |
nl-NL | Dutch (Netherlands) | ciclosporine^dalspiegel: Synonyms: IA |
pt-BR | Portuguese (Brazil) | Ciclosporina^basal: Synonyms: ; |
ru-RU | Russian (Russian Federation) | Циклоспорин^остаточная концентрация: Synonyms: Количественный Кровь Массовая концентрация минимум концентрации Точка во времени; |
tr-TR | Turkish (Turkey) | Siklosporin^en düşük: Synonyms: İmmünölçüm, immünoassay |
zh-CN | Chinese (China) | 环孢菌素^波谷: Synonyms: 一剂药物的初始剂量; |
Example Units
Unit | Source |
---|---|
ug/L | Example UCUM Units |
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LOINC Copyright
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