Version 2.80

Term Description

Determining the ratio of urinary-free cortisol to cortisone is useful in evaluating patients with apparent mineralocorticoid excess (AME) syndrome and other forms of adrenal insufficiency. Higher ratios are observed in patients with AME syndrome and indicate insufficient levels of 11-beta-hydroxy steroid dehydrogenase type 2 (11-beta HSD2), which converts cortisol to cortisone. Lower ratios suggests low activity of the 11-beta-HSD1 enzyme, which converts cortisone to cortisol, and may explain reduced effectiveness of cortisone treatment.

Part Descriptions

LP29041-8   Cortisol.free
Cortisol is a glucocorticoid produced in the adrenal cortex. A synthetic version of this same chemical is called hydrocortisone and manufactured as medication. Cortisol is not to be confused with cortisone, a closely related compound with much less (PubChem calls it "inactive") biologic activity. Cortisone is also offered as a drug, and it is converted to cortisol (the active form) in the liver. They both have a circadian rhythm with peak in the AM (around 8AM) and trough in the evening (around midnight), but this shifts according to sleep habits (work shifts). The morning measurement, which should be high, is most useful for diagnosing Addison's disease (too little cortisol) and the evening measurement, which should be low, is the most useful for diagnosing Cushing's disease (too much cortisol). Salivary cortisol may be a more sensitive measure than serum or plasma. Source: Regenstrief Help

LP70341-0   Cortisone.free
Cortisol is a glucocorticoid produced in the adrenal cortex. A synthetic version of this same chemical is called hydrocortisone and manufactured as medication. Cortisol is not to be confused with cortisone, a closely related compound with much less (PubChem calls it "inactive") biologic activity. Cortisone is also offered as a drug, and it is converted to cortisol (the active form) in the liver. They both have a circadian rhythm with peak in the AM (around 8AM) and trough in the evening (around midnight), but this shifts according to sleep habits (work shifts). The morning measurement, which should be high, is most useful for diagnosing Addison's disease (too little cortisol) and the evening measurement, which should be low, is the most useful for diagnosing Cushing's disease (too much cortisol). Salivary cortisol may be a more sensitive measure than serum or plasma. Source: Regenstrief Help

Fully-Specified Name

Component
Cortisol.free/Cortisone.free
Property
MRto
Time
Pt
System
Urine
Scale
Qn
Method

Additional Names

Long Common Name
Cortisol Free/Cortisone free [Mass Ratio] in Urine
Short Name
Cortis F/Cortisone Free Ur
Display Name
Cortisol Free/Cortisone free (U) [Mass ratio]
Consumer Name Alpha Get Info
Free cortisol/Free Cortisone, Urine

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.21
Last Updated
Version 2.73 (MIN)
Order vs. Observation
Both
Common Test Rank Get Info
14859

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Κορτιζόλη.ελεύθερη/Κορτιζόνη.ελεύθερη:MRto:Pt:Ούρα:Qn:
Synonyms: MRto Κορτιζόλη Κορτιζόλη.ελεύθερη Κορτιζόνη Κορτιζόνη.ελεύθερη
es-ES Spanish (Spain) Cortisol libre/Cortisona Libre:Relacion de Masa:Punto temporal:Orina:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Cortisol.libre/Cortisone.libre:Relación de masa:Punto temporal:Orina:Cuantitativo:
et-EE Estonian (Estonia) Kortisool.vaba/kortisoon.vaba:MRto:Pt:U:Qn:
Synonyms: Juhuslik Kvantitatiivne Uriin
fr-FR French (France) Cortisol libre/cortisone libre:Masse ratio:Ponctuel:Urine:Numérique:
it-IT Italian (Italy) Cortisolo.libero/Cortisone.libero:MRto:Pt:Urine:Qn:
Synonyms: Chimica Cortisolo Libero Punto nel tempo (episodio) Rapporto di Massa
nl-NL Dutch (Netherlands) cortisol.vrij/cortison.vrij:massaverhouding:moment:urine:kwantitatief:
pt-BR Portuguese (Brazil) Cortisol.livre/Cortisona.livre:MCrto:Pt:Urina:Qn:
Synonyms: ; Cortis F; Compound E; Coritsol; Compound F; 17-Hydroxycorticosterone; mRto; Mass concentration ratio; Point in time; Random; Ur; UR; Urn; UA; Quantitative; QNT; Quant; Quan; FR; Non-protein bound; Chemistry
ru-RU Russian (Russian Federation) Кортизол.свободный/Кортизон.свободный:МассОтн:ТчкВрм:Моча:Колич:
Synonyms: Количественный Масс отношение Точка во времени;Момент
tr-TR Turkish (Turkey) Kortizol.serb/Kortizon.serb:KütlOr:Zmlı:İdrar:Kant:
uk-UA Ukrainian (Ukraine) Кортизол.вільний/Кортизон.вільний:Масове Співвідношення:МоментЧасу:Сеча:Кількісно:
Synonyms: 11-beta HSD; 11-beta-HSD1; 11-beta-HSD2; 11-beta-hydroxy steroid dehydrogenase; 11-ß-HSD1; 11-ß-HSD2; 17-Hydroxycorticosterone; c155; Chemistry; Compound E; Compound F; Coritsol; Cort; Cortis F; Cortisone free; F; FR; hydrocortisone; Mass concentration ratio; Mass ratio; MCRto; Non-protein bound; Point in time; QNT; Quan; Quant; Quantitative; Random; UA; UR; Urn
zh-CN Chinese (China) 皮质醇.游离型/可的松.游离型:质量比率:时间点:尿液:定量型:
Synonyms: 17羟11脱氢皮甾酮;17-羟-11-脱氢皮甾酮;化合物 E 17-羟皮质甾酮;17-羟皮质酮;化合物 F;可的索;氢化可的松;皮质甾醇;考的索 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 可的松.游离 可的松.游离;游离可的松;游离型可的松 尿;小便;下泉 时刻;随机;随意;瞬间 来自于同一体系的两种分析物的质量之比;质量比 游离 皮质醇（可的索、考的索）.游离型;游离型皮质醇;游离皮质醇;皮质醇.游离 非蛋白结合型 非蛋白质结合型

Example Units

Unit Source
ug/ug Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=49029-2