49029-2

Cortisol Free/Cortisone free [Mass Ratio] in Urine

Active

Term Description

Determining the ratio of urinary-free cortisol to cortisone is useful in evaluating patients with apparent mineralocorticoid excess (AME) syndrome and other forms of adrenal insufficiency. Higher ratios are observed in patients with AME syndrome and indicate insufficient levels of 11-beta-hydroxy steroid dehydrogenase type 2 (11-beta HSD2), which converts cortisol to cortisone. Lower ratios suggests low activity of the 11-beta-HSD1 enzyme, which converts cortisone to cortisol, and may explain reduced effectiveness of cortisone treatment.

Part Descriptions

LP29041-8 Cortisol.free
Cortisol is a glucocorticoid produced in the adrenal cortex. A synthetic version of this same chemical is called hydrocortisone and manufactured as medication. Cortisol is not to be confused with cortisone, a closely related compound with much less (PubChem calls it "inactive") biologic activity. Cortisone is also offered as a drug, and it is converted to cortisol (the active form) in the liver. They both have a circadian rhythm with peak in the AM (around 8AM) and trough in the evening (around midnight), but this shifts according to sleep habits (work shifts). The morning measurement, which should be high, is most useful for diagnosing Addison's disease (too little cortisol) and the evening measurement, which should be low, is the most useful for diagnosing Cushing's disease (too much cortisol). Salivary cortisol may be a more sensitive measure than serum or plasma. Source: Regenstrief Help

LP70341-0 Cortisone.free
Cortisol is a glucocorticoid produced in the adrenal cortex. A synthetic version of this same chemical is called hydrocortisone and manufactured as medication. Cortisol is not to be confused with cortisone, a closely related compound with much less (PubChem calls it "inactive") biologic activity. Cortisone is also offered as a drug, and it is converted to cortisol (the active form) in the liver. They both have a circadian rhythm with peak in the AM (around 8AM) and trough in the evening (around midnight), but this shifts according to sleep habits (work shifts). The morning measurement, which should be high, is most useful for diagnosing Addison's disease (too little cortisol) and the evening measurement, which should be low, is the most useful for diagnosing Cushing's disease (too much cortisol). Salivary cortisol may be a more sensitive measure than serum or plasma. Source: Regenstrief Help

LOINC Names Get Info

Fully-Specified Name: Cortisol.free/Cortisone.free:MRto:Pt:Urine:Qn:
Long Common Name: Cortisol Free/Cortisone free [Mass Ratio] in Urine
Short Name: Cortis F/Cortisone Free Ur
Display Name: Cortisol Free/Cortisone free (U) [Mass ratio]
Consumer Name Alpha Get Info: Free cortisol/Free Cortisone, Urine

Part Model Get Info

Component
Cortisol.free/Cortisone.free
LP285810-0
- Analyte
  Cortisol.free/Cortisone.free
  LP285810-0
  - Component Numerator
    Cortisol.free
    LP29041-8
    - Component Numerator Core
      Cortisol.free
      LP29041-8
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    Cortisone.free
    LP70341-0
    - Component Denominator Core
      Cortisone.free
      LP70341-0
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
MRto
LP6834-8
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Urine
LP7681-2
- System Core
  Urine
  LP7681-2
- Super System
  NULL
Scale
Qn
LP7753-9
Method
NULL

Basic Attributes

Class: CHEM
Type: Laboratory
First Released: Version 2.21
Last Updated: Version 2.73 (MIN)
Order vs. Observation: Both
Common Test Rank Get Info: 14859

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Kortizol.volný/kortizon.volný:Hmotnostní poměr:Časový bod:Moč:Kvantitativní:
el-GR	Greek (Greece)	Κορτιζόλη.ελεύθερη/Κορτιζόνη.ελεύθερη:MRto:Pt:Ούρα:Qn: Synonyms: CHEM MRto Pt Qn Κορτιζόλη Κορτιζόλη.ελεύθερη Κορτιζόνη Κορτιζόνη.ελεύθερη Ούρα
es-ES	Spanish (Spain)	Cortisol libre/Cortisona Libre:Relacion de Masa:Punto temporal:Orina:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Cortisol.libre/Cortisone.libre:Relación de masa:Punto temporal:Orina:Cuantitativo:
et-EE	Estonian (Estonia)	Kortisool.vaba/kortisoon.vaba:MRto:Pt:U:Qn: Synonyms: Juhuslik Kvantitatiivne Uriin
fr-FR	French (France)	Cortisol libre/cortisone libre:Masse ratio:Ponctuel:Urine:Numérique:
it-IT	Italian (Italy)	Cortisolo.libero/Cortisone.libero:MRto:Pt:Urine:Qn: Synonyms: Chimica Cortisolo Libero Punto nel tempo (episodio) Rapporto di Massa
nl-NL	Dutch (Netherlands)	cortisol.vrij/cortison.vrij:massaverhouding:moment:urine:kwantitatief:
pl-PL	Polish (Poland)	Kortyzol.wolny/kortyzon wolny:współczynnik masowy:punkt w czasie:mocz:ilościowy: Synonyms: Wolny kortyzon
pt-BR	Portuguese (Brazil)	Cortisol.livre/Cortisona.livre:MCrto:Pt:Urina:Qn: Synonyms: ; Cortis F; Compound E; Coritsol; Compound F; 17-Hydroxycorticosterone; mRto; Mass concentration ratio; Point in time; Random; Ur; UR; Urn; UA; Quantitative; QNT; Quant; Quan; FR; Non-protein bound; Chemistry
ru-RU	Russian (Russian Federation)	Кортизол.свободный/Кортизон.свободный:МассОтн:ТчкВрм:Моча:Колич: Synonyms: Количественный Масс отношение Точка во времени;Момент
tr-TR	Turkish (Turkey)	Kortizol.serb/Kortizon.serb:KütlOr:Zmlı:İdrar:Kant:
uk-UA	Ukrainian (Ukraine)	Кортизол.вільний/Кортизон.вільний:Масове Співвідношення:МоментЧасу:Сеча:Кількісно: Synonyms: 11-beta HSD; 11-beta-HSD1; 11-beta-HSD2; 11-beta-hydroxy steroid dehydrogenase; 11-ß-HSD1; 11-ß-HSD2; 17-Hydroxycorticosterone; c155; Chemistry; Compound E; Compound F; Coritsol; Cort; Cortis F; Cortisone free; F; FR; hydrocortisone; Mass concentration ratio; Mass ratio; MCRto; Non-protein bound; Point in time; QNT; Quan; Quant; Quantitative; Random; UA; UR; Urn
zh-CN	Chinese (China)	皮质醇.游离型/可的松.游离型:质量比率:时间点:尿液:定量型: Synonyms: 17羟11脱氢皮甾酮;17-羟-11-脱氢皮甾酮;化合物 E 17-羟皮质甾酮;17-羟皮质酮;化合物 F;可的索;氢化可的松;皮质甾醇;考的索化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类可用数量表示的;定量性;数值型;数量型;连续数值型标尺可的松.游离可的松.游离;游离可的松;游离型可的松尿;小便;下泉时刻;随机;随意;瞬间来自于同一体系的两种分析物的质量之比;质量比游离皮质醇（可的索、考的索）.游离型;游离型皮质醇;游离皮质醇;皮质醇.游离非蛋白结合型非蛋白质结合型

Example Units

Unit	Source
ug/ug	Example UCUM Units

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