Version 2.78

Term Description

The ratio of HER-2/neu (ERBB2 gene) to CEP17 probes by in situ hybridization assays (e.g. FISH) to determine overexpression of HER-2/neu protein in breast cancer. CEP17 is used as an internal control and to account for aneusomy (varying number) of chromosome 17. A ratio of >2.0 indicates gene amplification and overexpression of HER-2/neu according to the 2013 ASCO-CAP HER2 test guideline recommendations. Results are used to assist in dose selection for certain drugs, assess eligibility for trastuzumab (Herceptin®) treatment, predict response to drug therapies and overall survival in patients with breast cancer. For testing without an internal control probe, see LOINCs 31150-6 and 48675-3. For determining HER-2 status by Immunohistochemistry (IHC), see LOINC 18474-7.
Source: Regenstrief LOINC

Part Descriptions

LP182376-6   ERBB2 gene copy number
HER2/neu (also known as ErbB-2) stands for "Human Epidermal growth factor Receptor 2" and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2/neu has also been designated as CD340 (cluster of differentiation 340) and p185. It is encoded by the ERBB2 gene. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LP62864-1   FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, FISH

Fully-Specified Name

Component
ERBB2 gene copy number/Chromosome 17 copy number
Property
NRto
Time
Pt
System
Tiss
Scale
Qn
Method
FISH

Additional Names

Short Name
ERBB2 copy num/Chr 17 copy num Tiss FISH
Display Name
ERBB2 copy number/Chromosome 17 copy number FISH (Tiss) [# ratio]
Consumer Name Alpha Get Info
ERBB2 copy number/Chromosome 17 copy number, Tissue

Basic Attributes

Class
MOLPATH
Type
Laboratory
First Released
Version 2.22
Last Updated
Version 2.73
Change Reason
Release 2.70: COMPONENT: Corrected the gene name based on the LOINC model to use the approved HGNC name for the gene that encodes the HER2 receptor.; Previous Releases: Updated Component from "HER2/CEP17" and Property from "Ratio" to align with current nomenclature and similar terms
Order vs. Observation
Both
Common Test Rank Get Info
7211

Member of these Panels

LOINC Long Common Name
85904-1 Cancer pathology panel - Breast cancer specimen by CAP cancer protocols
74885-5 ERBB2 gene (HER2) duplication associated observations panel - Tissue by FISH

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Señales HER2/CEP17:Relación de número:Punto temporal:Tejido:Qn:Hibridación in situ fluoresente (FISH)
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Número de copia del gen HER2 / Número de copia del cromosoma 17:Proporción numérica:Punto temporal:Tejido y frotis:Cuantitativo:Hibridación fluorescente in situ (FISH)
fr-FR French (France) HER2 gène/chromosome 17 nombre de copie:Nombre/Nombre:Ponctuel:Tissu:Numérique:FISH
fr-CA French (Canada) ERBB2 gène duplication/Nombre de copie du chromosome 17:Ratio de numérique:Temps ponctuel:Tissu:Quantitatif:Hybridation fluorescente in situ
it-IT Italian (Italy) ERBB2,numero copia del gene/CEP17:NRto:Pt:Tessuto:Qn:FISH
Synonyms: Gene ERBB2 Ibridazione in situ fluorescente (FISH) Patologia molecolare Punto nel tempo (episodio) Rapporto numerico Tessuto & Strisci
nl-NL Dutch (Netherlands) aantal kopieën van ERBB2-gen/aantal centromeren van chromosoom 17:aantalsverhouding:moment:weefsel en uitstrijkjes:kwantitatief:FISH
Synonyms: CEP17 ERBB2 gen HER2
pt-BR Portuguese (Brazil) HER2/CEP17:Ratio:Pt:Tecido:Qn:FISH (hibridização in situ fluorescente)
Synonyms: HER-2/neu; HER-2; ERB2; C-ERBB-2; erb; erbB2; ERB-2; Rto; Point in time; Random; Tissue; Quantitative; QNT; Quant; Quan; Fluorescent in situ hybridization; Molecular pathology
tr-TR Turkish (Turkey) HER2 sinyallaeri/CEP17:SayOr:Zmlı:Doku:Kant:FISH
zh-CN Chinese (China) HER2 基因拷贝数/染色体 17 拷贝数:计数型比率:时间点:组织与涂片:定量型:FISH
Synonyms: c-erb B2;Her2;HER-2/neu;NGL;TKR1;V-ERB-B2 禽类成红血细胞性白血病病毒性致癌基因同源基因 2 (神经/恶性胶质瘤源性癌基因同源基因);V-ERB-B2 禽类成红血细胞性白血病病毒性致癌基因同源基因 2 (神经/恶性胶质瘤源性致癌基因同源基因);V-ERB-B2 禽类成红血细胞性白血病病毒性致癌基因同源基因 2 (神经/成胶质细胞瘤源性癌基因同源基因);V-ERB-B2 禽类成红血细胞性白血病病毒性致癌基因同源基因 2 (神经/成胶质细胞瘤源性致癌基因同源基因);V- Fluorescent in situ hybridization;荧光原位杂交 HER2 基因拷贝（副本）数（数量、计数）;HER2 信号 个数;数目 分子病理学;分子病理学试验 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 同一样本内两种不同实体的数量之比;数量型比;数量型比值;数量型比率;数量或计数型比;数量或计数型比值;计数型比;计数型比值;数量或计数型比率 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 染色体 17 （17号染色体）拷贝（副本）数（数量、计数）;17号染色体拷贝（副本）数（数量、计数）;CEP17;CEP17 信号 染色体 17 （17号染色体）拷贝（副本）数（数量、计数）;17号染色体拷贝数;CEP17 染色体二体型+染色体三体型 遗传基因;遗传因子;吉恩;生物基因

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=49683-6