Version 2.78

Part Descriptions

LP16474-6   Interleukin 6
Interleukin-6 (IL-6) is a protein that in humans is encoded by the IL6 gene.

IL-6 is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. In terms of host response to a foreign pathogen, IL-6 has been shown, in mice, to be required for resistance against the bacterium, Streptococcus pneumoniae. IL-6 is also a "myokine," a cytokine produced from muscle, and is elevated in response to muscle contraction. It is significantly elevated with exercise, and precedes the appearance of other cytokines in the circulation. During exercise, it is thought to act in a hormone-like manner to mobilize extracellular substrates and/or augment substrate delivery. Additionally, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine. IL-6's role as an anti-inflammatory cytokine is mediated through its inhibitory effects on TNF-alpha and IL-1, and activation of IL-1ra and IL-10. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LP16474-6   Interleukin 6
The Interleukins belong to the family termed cytokines. They are peptides used by immune and inflammatory cells to communicate and control cell operations. The cytokines have some similar actions to the Growth Factors but Growth Factors regulate proliferation of non-immune cells. Interleukin 6 is a 25,000 molecular weight glycoprotein produced primarily in macrophages, T cells, fibroblasts and endothelial cells. Its primary target cells are T and B cells and neutrophils. Its main actions are involvement in terminal differentiation of B cells to antibody secreting plasma cells, activation of T cells and stimulation of hepatocyte production of acute phase proteins. Interleukin stimulates Prolactin, Growth Hormone, Luteinizing Hormone, Follicle Stimulating Hormone and ACTH. Release is stimulated by Interleukin 1a and b, Vasoactive Intestinal Polypeptide, and Prostaglandin E2. Release is not affected by aspirin or indomethacin. Levels are elevated in multiple myeloma, rheumatoid arthritis, systemic lupus erythematosus, meningococcus meningitis and infectious peritonitis. Source: Inter Science Institute, Inter Science Institute

Fully-Specified Name

Component
Interleukin 6
Property
MCnc
Time
Pt
System
CSF
Scale
Qn
Method

Additional Names

Short Name
Il6 CSF-mCnc
Display Name
Interleukin 6 (CSF) [Mass/Vol]
Consumer Name Alpha Get Info
Interleukin 6, Spinal fluid

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.22
Last Updated
Version 2.70
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Interleukin-6:Massenkonzentration:Zeitpunkt:Liquor:Quantitativ:
Synonyms: IL-6; Zerebrospinalflüssigkeit
de-AT German (Austria) Synonyms: Interleukin-6 /L
es-ES Spanish (Spain) Interleukina 6:Concentración de masa:Punto temporal:Líquido Cefalorraquideo:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Interleucina 6:Concentración de masa:Punto temporal:Fluído espinal cerebral:Cuantitativo:
et-EE Estonian (Estonia) Interleukiin 6:MCnc:Pt:CSF:Qn:
Synonyms: Juhuslik Kvantitatiivne Liikvor
fr-CA French (Canada) Interleukine 6:Concentration de masse:Temps ponctuel:LCR:Quantitatif:
fr-FR French (France) Interleukine-6:Masse/Volume:Ponctuel:Liquide céphalorachidien:Numérique:
fr-BE French (Belgium) Interleukine 6:Concentration de masse:Temps ponctuel:LCR:Quantitatif:
Synonyms: Il6
it-IT Italian (Italy) Interleuchina 6:MCnc:Pt:LCS:Qn:
Synonyms: Chimica Concentrazione di Massa Liquido cerebrospinale Punto nel tempo (episodio)
nl-NL Dutch (Netherlands) interleukine 6:massa/volume:moment:liquor cerebrospinalis:kwantitatief:
pt-BR Portuguese (Brazil) Interleucina 6:MCnc:Pt:LCR:Qn:
Synonyms: ; Il6; IL-6; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; Hepatocyte-Stimulating Factor; IL6; Hybridoma Growth Factor; MGI-2; Myeloid Differentiation-Inducing Protein; Plasmacytoma Growth Factor; BSF-2; IFN-beta 2; Mass concentration; Level; Point in time; Random; Cerebral spinal fluid; Spinal Fluid; Cerebrospinal Fl; Spinal Flu; Spinal Fld; Quantitative; QNT; Quant; Quan; IL; Chemistry
ru-RU Russian (Russian Federation) Интерлейкин 6:МассКонц:ТчкВрм:ЦСЖ:Колич:
Synonyms: Количественный Массовая концентрация Точка во времени;Момент Цереброспинальная жидкость
tr-TR Turkish (Turkey) İnterlökin 6:KütlKons:Zmlı:BOS:Kant:
zh-CN Chinese (China) 白细胞介素 6:质量浓度:时间点:脑脊液:定量型:
Synonyms: B 细胞分化因子-2;B 细胞刺激因子-2;BSF-2;B-细胞分化因子-2;B-细胞刺激因子-2;IFN-beta 2;IFN-β2;Il6;IL-6;MGI-2;杂交瘤生长因子;浆细胞瘤生长因子;白介素 6;白介素-6;白细胞介素-6;肝细胞刺激因子;髓系分化诱导因子 CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 IL 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 水平;浓度;质量浓度(单位体积) 白介 白介素 白细胞介素（Interleukin，白介素，IL） 脊液 脊髓液 脑脊液（Cerebral spinal fluid，CSF） 脑脊髓液

Example Units

Unit Source
pg/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=49919-4