50036-3

Dengue virus neutralizing antibody [Presence] in Specimen by Neutralization test

Active

Part Descriptions

LP207365-0 Ab.Neut
Neutralizing antibodies are antibodies that interfere with the interaction between the virus and its host cell receptor, therefore preventing infectivity. Neutralizing antibodies can be detected using a traditional VNT or other methods such as pseudovirus VNT and surrogate VNT. VNT and pseudovirus VNT use live virus (the actual virus or a recombinant virus that incorporates the viral antigen of interest, respectively) and cell culture to assess the virus-host interaction and whether neutralizing antibodies are present that block that interaction. Surrogate VNT (sVNT) does not use live virus but rather uses purified viral antigen and host cell receptor protein to mimic the same interaction. The sVNT method is currently (2021) represented in LOINC as IA, because it is an immunoassay-based method. Source: Regenstrief LOINC

LP6416-4 Neut
In LOINC, the Method "Neut" represents the virus neutralization test (VNT), also called conventional VNT, which is a specific laboratory method that is used primarily for identifying whether neutralizing antibodies for the virus of interest are present in the patient sample. The VNT involves incubating patient serum with the virus of interest, and then inoculating onto cell culture. If neutralizing antibodies are present and the virus is neutralized, the cells will not be infected. If neutralizing antibodies are not present, the virus will infect the cells in the cell culture. PMID: 32170698 This method can also be used to identify specific virus serotypes or strains, by performing separate tests in which serum is incubated with each of the specific virus serotypes or strains of interest. PMID: 169804 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Dengue virus Ab.Neut:PrThr:Pt:XXX:Ord:Neut
Long Common Name: Dengue virus neutralizing antibody [Presence] in Specimen by Neutralization test
Short Name: DENV NAb Spec Ql Nt
Display Name: DENV neut ab Neut test Ql (Specimen)
Consumer Name Alpha Get Info: Dengue virus neutralizing antibody, Specimen

Part Model Get Info

Component
Dengue virus Ab.Neut
LP430363-4
- Analyte
  Dengue virus Ab.Neut
  LP430363-4
  - Component Numerator
    Dengue virus Ab.Neut
    LP430363-4
    - Component Numerator Core
      Dengue virus
      LP14385-6
    - Component Numerator Core Suffix
      Ab.Neut
      LP207365-0
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
XXX
LP7735-6
- System Core
  XXX
  LP7735-6
- Super System
  NULL
Scale
Ord
LP7751-3
Method
Neut
LP6416-4

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.22
Last Updated: Version 2.72 (NAM)
Change Reason: Release 2.72: COMPONENT: Updated "Ab" to "Ab.Neut" since this test is detecting neutralizing antibodies.; Previous Releases: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both

Member of these Groups Get Info

LOINC Group	Group Name
LG32760-7	Dengue virus

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Virus horečky dengue Ab.neutralizační:Přítomnost nebo práh:Časový bod:XXX:Ordinální:Neutralizační test
el-GR	Greek (Greece)	Ιός δάγγειου πυρετού Ab.Neut:PrThr:Pt:XXX:Ord:Ουδετερόφιλα Synonyms: Ab.Neut MICRO Ord PrThr Pt XXX Αντίσωμα Ιός Ιός δάγγειου πυρετού Ουδετερόφιλα
es-ES	Spanish (Spain)	Virus del Denge Anticuerpos antineutrófilos:PrThr:Punto temporal:XXX:Ord:Prueba de neutralización
es-MX	Spanish (Mexico)	Ab virus del dengue:Presencia o umbral:Punto temporal:XXX:Ordinal:Prueba de neutralización
fr-FR	French (France)	Dengue virus Ac neutralisant:Présence/Seuil:Ponctuel:Milieux divers:Qualitatif:Neutralisation
fr-CA	French (Canada)	Virus de la dengue Ac.neut:Présence-Seuil:Temps ponctuel:XXX:Ordinal:Test de neutralisation
it-IT	Italian (Italy)	Dengue virus Ab.Neut:PrThr:Pt:XXX:Ord:Neut Synonyms: anticorpo Microbiologia Presenza o Soglia Punto nel tempo (episodio) Test di neutralizzazione
nl-NL	Dutch (Netherlands)	Denguevirus As.neutraliserend:aanwezigheid:moment:XXX:ordinaal:neutralisatietest Synonyms: antistof; antilichaam
pl-PL	Polish (Poland)	Wirus dengi Ab.Neutralizujące:granica wykrywalności:punkt w czasie:XXX:uporządkowany:test neutralizacji Synonyms: Przeciwciała do wirusa dengi Przeciwciała nautralizujące do wirusa dengi Wirus dengi
pt-BR	Portuguese (Brazil)	Dengue vírus Ac:ACnc:Pt:XXX:Ord:Teste de neutralização Synonyms: ; DENV; Flavivirus; Breakbone fever; Arbitrary concentration; Point in time; Random; Misc; Miscellaneous; Unspecified; Other; Ql; Ordinal; QL; Qualitative; Qual; Screen; Nt; NT; Neutralization test; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; Microbiology
zh-CN	Chinese (China)	登革热病毒抗体.中和:存在情况或阈值:时间点:XXX:序数型:中和试验 Synonyms: Ab;自身抗体 DENV Ab DENV 抗体 DENV;地方性蔷薇疹热;登革热;登革病毒;黄病毒不明的;其他;将在相应消息内其他部分之中加以详细说明;未作详细说明的;未作说明的;未做说明的标本;未加规定的;未加说明的标本;杂项中和试验;中和抗体;中和传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）时刻;随机;随意;瞬间登革热病毒 Ab

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.