50093-4

21-Deoxycortisol [Moles/volume] in Amniotic fluid

Active

Part Description

LP65144-5 21-Deoxycortisol
Plasma 21-deoxycortisol (21DF) is an excellent marker of 21-hydroxylase deficiency. Currently, it is the only marker able to detect heterozygous carriers with 21-hydroxylase deficiency after Adrenocorticotropic Hormone (ACTH) stimulation. The syndrome of congenital adrenal hyperplasia (CAH) comprises the spectrum of autosomal recessive enzymatic disorders that impair cortisol biosynthesis. The hormonal pattern and clinical manifestations result from hyperstimulation of the adrenal cortex by excessive production of ACTH, untied from the negative feedback exerted by reduced cortisol levels, and the ultimate accumulation of F precursors and androgens. These abnormalities predispose the female newborn to ambiguous genitalia (female pseudohermaphroditism) and precocious puberty that may occur in both sexes. CAH due to 21-hydroxylase deficiency (21OHD) comprises nearly 90% of all cases, with an estimated worldwide incidence of 1 in 14,000 live births. Because 21-deoxycortisol (21DF) is an 11b-hydroxylase (11bOH) derivative of 17-hydroxyprogesterone (17OHP), its serum levels are parallel and proportionally elevated in patients with 21OHD but decreased or undetectable in those with 11b-hydroxylase deficiency (11bOHD). Due to the marked buildup of 17OHP in 21OHD, this precursor steroid can proceed directly to 11-hydroxylation, producing distinct elevations of 21DF. PMID: 16551734, PMID: 10731638 Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, 21-Deoxycortisol

LOINC Names Get Info

Fully-Specified Name: 21-Deoxycortisol:SCnc:Pt:Amnio fld:Qn:
Long Common Name: 21-Deoxycortisol [Moles/volume] in Amniotic fluid
Short Name: 21DC Amn-sCnc
Display Name: 21-Deoxycortisol (Amn fld) [Moles/Vol]
Consumer Name Alpha Get Info: 21-Deoxycortisol, Amniotic fluid

Part Model Get Info

Component
21-Deoxycortisol
LP65144-5
- Analyte
  21-Deoxycortisol
  LP65144-5
  - Component Numerator
    21-Deoxycortisol
    LP65144-5
    - Component Numerator Core
      21-Deoxycortisol
      LP65144-5
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
SCnc
LP6860-3
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Amnio fld
LP7000-5
- System Core
  Amnio fld
  LP7000-5
- Super System
  NULL
Scale
Qn
LP7753-9
Method
NULL

Basic Attributes

Class: CHEM
Type: Laboratory
First Released: Version 2.22
Last Updated: Version 2.70 (MIN)
Order vs. Observation: Both

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	21-deoxykortizol:Látková koncentrace:Časový bod:Amniová tekutina:Kvantitativní:
el-GR	Greek (Greece)	21-δεοξυκορτιζόλη:SCnc:Pt:Αμνιακό υγρό:Qn: Synonyms: 21-δεοξυκορτιζόλη CHEM Pt Qn SCnc Αμνιακό υγρό
es-ES	Spanish (Spain)	21-Deoxicortisol:Concentración de sustancia:Punto temporal:Fluido Ammiótico:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	21-desoxicortisol:Concentración de sustancias:Punto temporal:Líquido amniótico:Cuantitativo:
et-EE	Estonian (Estonia)	21-deoksükortisool:SCnc:Pt:AmnF:Qn: Synonyms: Aine kontsentratsioon Amnionivedelik Juhuslik Kvantitatiivne
fr-CA	French (Canada)	21-désoxycortisol:Concentration de substance:Temps ponctuel:Liquide amniotique:Quantitatif:
fr-FR	French (France)	21-déoxycortisol:Moles/Volume:Ponctuel:Liquide amniotique:Numérique:
fr-BE	French (Belgium)	21-déoxycortisol:Concentration de substance:Temps ponctuel:Liquide amniotique:Quantitatif:
it-IT	Italian (Italy)	21-Deossicortisolo:SCnc:Pt:Liquido amniotico:Qn: Synonyms: Chimica Concentrazione di Sostanza Liquido amniotico Punto nel tempo (episodio)
nl-NL	Dutch (Netherlands)	21-deoxycortisol:mol/volume:moment:vruchtwater:kwantitatief:
pl-PL	Polish (Poland)	21-Deoksykortyzol:stężenie molowe:punkt w czasie:płyn owodniowy:ilościowy:
pt-BR	Portuguese (Brazil)	21-Deoxicortisol:SCnc:Pt:LiqAmni:Qn: Synonyms: ; 21DC; Substance concentration; Level; Point in time; Random; Amn; Amniotic fluid; Amn fl; Amniotic flu; AF; Quantitative; QNT; Quant; Quan; Chemistry
ru-RU	Russian (Russian Federation)	21-Дезоксикортизол:МолКонц:ТчкВрм:Амниотич ждк:Колич: Synonyms: Амниотическая жидкость Количественный Молярность;Молярная объёмная концентрация Точка во времени;Момент
tr-TR	Turkish (Turkey)	21-Deoksikortizol:SubKons:Zmlı:Amniyon sv:Kant: Synonyms: Amniyon mayii
zh-CN	Chinese (China)	21-脱氧皮质醇:物质的量浓度:时间点:羊水:定量型: Synonyms: 21DC;21-脱氧可的索;21-脱氧氢化可的松;21-脱氧皮质甾醇;21-脱氧考的索克分子浓度;克分子浓度(单位体积);摩尔浓度;摩尔浓度(单位体积);物质的量浓度(单位体积) 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类可用数量表示的;定量性;数值型;数量型;连续数值型标尺时刻;随机;随意;瞬间羊膜水;胎水

Example Units

Unit	Source
pmol/L	Example UCUM Units

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.