50314-4
Cytokeratin 19 Ag [Presence] in Tissue by Immune stain
Active
Part Description
LP19423-0 Cytokeratin 19
Keratin, type I cytoskeletal 19 also known as cytokeratin-19 (CK-19) or keratin-19 (K19) is a protein that in humans is encoded by the KRT19 gene.
Due to its high sensitivity, KRT19 is the most used marker for the RT-PCR-mediated detection of tumor cells disseminated in lymph nodes, peripheral blood, and bone marrow of breast cancer patients. Depending on the assays, KRT19 has been shown to be both a specific and a non-specific marker. False positivity in such KRT19 RT-PCR studies include: illegitimate transcription (expression of small amounts of KRT19 mRNA by tissues in which it has no real physiological role), haematological disorders (KRT19 induction in peripheral blood cells by cytokines and growth factors, which circulate at higher concentrations in inflammatory conditions and neutropenia), the presence of pseudogenes (two KRT19 pseudogenes, KRT19a and KRT19b, have been identified, which have significant sequence homology to KRT19 mRNA. Subsequently, attempts to detect the expression of the authentic KRT19 may result in the detection of either or both of these pseudogenes), sample contamination (introduction of contaminating epithelial cells during peripheral blood sampling for subsequent RT-PCR analysis).
Keratin 19 is often used together with keratin 8 and keratin 18 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.
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Source: Wikipedia
, Wikipedia
Fully-Specified Name
- Component
- Cytokeratin 19 Ag
- Property
- PrThr
- Time
- Pt
- System
- Tiss
- Scale
- Ord
- Method
- Immune stain
Additional Names
- Long Common Name
- Cytokeratin 19 Ag [Presence] in Tissue by Immune stain
- Short Name
- CK 19 Ag Tiss Ql ImStn
- Display Name
- Cytokeratin 19 Ag Immune stain Ql (Tiss)
- Consumer Name Alpha Get Info
- Cytokeratin 19 antigen, Tissue
Basic Attributes
- Class
- PATH
- Type
- Laboratory
- First Released
- Version 2.22
- Last Updated
- Version 2.73 (MIN)
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 15264
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Κυτοκερατίνη 19 Αντιγόνο: Synonyms: PrThr Κυτοκερατίνη 19 |
| es-ES | Spanish (Spain) | Citoqueratina 19 Antígeno: |
| es-MX | Spanish (Mexico) | Citoqueratina 19 Ag: |
| et-EE | Estonian (Estonia) | Tsütokeratiin 19 antigeen: Synonyms: Järgarvuline Juhuslik Kude |
| fr-CA | French (Canada) | Cytokératine 19, Ag: |
| fr-FR | French (France) | Cytokératine 19 antigène: |
| fr-BE | French (Belgium) | Cytokératine 19 Ag: Synonyms: Antigène Coloration. Méthode mmunologique |
| it-IT | Italian (Italy) | Citocheratina 19, Ag: Synonyms: Patologia Presenza o Soglia Punto nel tempo (episodio) Tessuto & |
| nl-NL | Dutch (Netherlands) | cytokeratine 19 Ag: Synonyms: antigeen |
| pl-PL | Polish (Poland) | Cytokeratyna 19 Ag: Synonyms: Antygen cytokeratyny 19 barwnik immunologiczny |
| pt-BR | Portuguese (Brazil) | Citoqueratina 19 Ag: Synonyms: ; |
| ru-RU | Russian (Russian Federation) | Цитокератин 19 Аг: Synonyms: Порядковый Ткань и мазки Точка во времени; |
| tr-TR | Turkish (Turkey) | Sitokeratin 19 Ag: Synonyms: Mevcut |
| zh-CN | Chinese (China) | 细胞角蛋白 19 抗原: Synonyms: Ag CK 19 Ag CK 19 抗原 CK 19; |
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- CodeSystem lookup
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