LP19423-0
Cytokeratin 19
Active
Description
Keratin, type I cytoskeletal 19 also known as cytokeratin-19 (CK-19) or keratin-19 (K19) is a protein that in humans is encoded by the KRT19 gene.
Due to its high sensitivity, KRT19 is the most used marker for the RT-PCR-mediated detection of tumor cells disseminated in lymph nodes, peripheral blood, and bone marrow of breast cancer patients. Depending on the assays, KRT19 has been shown to be both a specific and a non-specific marker. False positivity in such KRT19 RT-PCR studies include: illegitimate transcription (expression of small amounts of KRT19 mRNA by tissues in which it has no real physiological role), haematological disorders (KRT19 induction in peripheral blood cells by cytokines and growth factors, which circulate at higher concentrations in inflammatory conditions and neutropenia), the presence of pseudogenes (two KRT19 pseudogenes, KRT19a and KRT19b, have been identified, which have significant sequence homology to KRT19 mRNA. Subsequently, attempts to detect the expression of the authentic KRT19 may result in the detection of either or both of these pseudogenes), sample contamination (introduction of contaminating epithelial cells during peripheral blood sampling for subsequent RT-PCR analysis).
Keratin 19 is often used together with keratin 8 and keratin 18 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.
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Source: Wikipedia, Wikipedia
Basic Part Properties
- Part Display Name
- Cytokeratin 19
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- CK 19
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 细胞角蛋白 19 Synonyms: CK 19; |
| fr-CA | French (Canada) | Cytokératine 19 |
| et-EE | Estonian (Estonia) | Tsütokeratiin 19 |
| es-ES | Spanish (Spain) | Citoqueratina 19 |
| it-IT | Italian (Italy) | Citocheratina 19 |
| tr-TR | Turkish (Turkey) | Sitokeratin 19 |
| ru-RU | Russian (Russian Federation) | Цитокератин 19 |
| nl-NL | Dutch (Netherlands) | cytokeratine 19 |
| fr-BE | French (Belgium) | Cytokératine 19 |
| pl-PL | Polish (Poland) | Cytokeratyna 19 |
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