50747-5

Platelet factor 4 Ag [Presence] in Platelet poor plasma by Immunoassay

Active

Part Descriptions

LP16902-6 Platelet factor 4
A high-molecular-weight proteoglycan-platelet factor complex which is released from blood platelets by thrombin. It acts as a mediator in the heparin-neutralizing capacity of the blood and plays a role in platelet aggregation. At high ionic strength (I=0.75), the complex dissociates into the active component (molecular weight 29,000) and the proteoglycan carrier (chondroitin 4-sulfate, molecular weight 350,000). The molecule exists in the form of a dimer consisting of 8 moles of platelet factor 4 and 2 moles of proteoglycan. Source: National Library of Medicine, MeSH 2006

LP16902-6 Platelet factor 4
Platelet factor-4 (PF4) is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major role is to neutralize heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 may play a role in inflammation and wound repair. The heparin:PF4 complex is the immunogen in heparin-induced thrombocytopenia, an idiosyncratic autoimmune reaction that sometimes occurs following the injection of heparin. PF4 autoantibodies have also been observed in patients with thrombosis and features resembling HIT although these patients did not receive heparin. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LOINC Names Get Info

Fully-Specified Name: Platelet factor 4 Ag:PrThr:Pt:PPP:Ord:IA
Long Common Name: Platelet factor 4 Ag [Presence] in Platelet poor plasma by Immunoassay
Short Name: PF4 Ag PPP Ql IA
Display Name: Platelet factor 4 Ag IA Ql (PPP)
Consumer Name Alpha Get Info: Platelet factor 4 antigen, Blood

Part Model Get Info

Component
Platelet factor 4 Ag
LP39435-0
- Analyte
  Platelet factor 4 Ag
  LP39435-0
  - Component Numerator
    Platelet factor 4 Ag
    LP39435-0
    - Component Numerator Core
      Platelet factor 4
      LP16902-6
    - Component Numerator Core Suffix
      Ag
      LP20666-1
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
PPP
LP7494-0
- System Core
  PPP
  LP7494-0
- Super System
  NULL
Scale
Ord
LP7751-3
Method
IA
LP217197-5

Basic Attributes

Class: COAG
Type: Laboratory
First Released: Version 2.22
Last Updated: Version 2.73 (MIN)
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; Renamed Method from "Imm" to "IA" for consistency across classes (approved by Laboratory LOINC Committee 2016 12).
Order vs. Observation: Both
Common Test Rank Get Info: 19892

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Trombocytární faktor 4 Ag:Přítomnost nebo práh:Časový bod:Plazma chudá na trombocyty:Ordinální:Imunoanalýza
de-DE	German (Germany)	Thrombozytenfaktor 4 Ag:Nachweis oder Schwellenwert:Zeitpunkt:Thrombozytenarmes Plasma:Ordinal:Immunoassay
el-GR	Greek (Greece)	Παράγοντας αιμοπεταλίων 4 Αντιγόνο:PrThr:Pt:PPP:Ord:IA Synonyms: COAG IA Ord PPP PrThr Pt Αιμοπετάλιο Αντιγόνο Παράγοντας αιμοπεταλίων 4
es-ES	Spanish (Spain)	Factor plaquetario 4 Antígeno:PrThr:Punto temporal:Plasma pobre en plaquetas:Ord:IA
es-MX	Spanish (Mexico)	Factor plaquetario 4 Ag:Presencia o umbral:Punto temporal:Plasma pobre en plaquetas:Ordinal:Inmunoensayo
et-EE	Estonian (Estonia)	Trombotsüütide 4. faktor antigeen:PrThr:Pt:PPP:Ord:IA Synonyms: Järgarvuline Juhuslik Trombotsüütidevaene plasma
fr-CA	French (Canada)	Facteur 4 plaquettaire, Ag:Présence-Seuil:Temps ponctuel:Plasma pauvre en plaquettes:Ordinal:IA
fr-FR	French (France)	Facteur 4 plaquettaire Ag:Présence/Seuil:Ponctuel:Plasma pauvre en plaquettes:Qualitatif:Immunoanalyse
fr-BE	French (Belgium)	Facteur 4 plaquettaire Ag:PrThr:Temps ponctuel:Plasma pauvre en plaquettes:Ordinal:IA Synonyms: Antigène PF4
it-IT	Italian (Italy)	Fattore piastrinico 4, Ag:PrThr:Pt:PPP:Ord:IA Synonyms: Immunoassay Piastrine Plasma povero di piastrine Presenza o Soglia Punto nel tempo (episodio) Studio di coagulazione
nl-NL	Dutch (Netherlands)	plaatjes factor 4 Ag:aanwezigheid:moment:plaatjesarm plasma:ordinaal:immunoassay Synonyms: antigeen coagulatiemethode IA
pl-PL	Polish (Poland)	Czynnik płytkowy 4 Ag:granica wykrywalności:punkt w czasie:osocze ubogopłytkowe:uporządkowany:metoda immunologiczna Synonyms: Antygen czynnika płytkowego 4 Czynnik płytkowy PPP
pt-BR	Portuguese (Brazil)	Fator plaquetário 4 Ag:ACnc:Pt:PPPQ:Ord:Imunológico Synonyms: ; PF4; Heparin-Induced Platelet Ac; PI-factor 4; Platelet type heparin inactivator; PF; Plt; Pl; Platelets; Thrombocytes; Platelt; Thrombocyte; Arbitrary concentration; Point in time; Random; Platelet poor plasma; Plas; Ql; Ordinal; QL; Qualitative; Qual; Screen; Immunology; Immunol; Antigen; Antigens; Fac; Fact; COAGULATION
ru-RU	Russian (Russian Federation)	Пластинка фактор 4 Аг:PrThr:ТчкВрм:ОПП:Пор:IA Synonyms: Обеднённая пластинками плазма;Бедная тромбоцитами плазма Порядковый Точка во времени;Момент Тромбоцит Тромбоцитарный фактор 4
tr-TR	Turkish (Turkey)	Trombosit faktör 4 Ag:MevcEşik:Zmlı:TFkP:Srl:İA Synonyms: Antijen İmmünölçüm, immünoassay Mevcut
zh-CN	Chinese (China)	血小板因子 4 抗原:存在情况或阈值:时间点:贫血小板血浆:序数型:免疫测定法 Synonyms: Ag PF4;PI-因子 4;肝素诱导型血小板 AB（Heparin-Induced Platelet AB）;血小板因子 4（Platelet factor 4，PF4）;血小板型肝素灭活剂（Platelet type heparin inactivator）乏血小板血浆;Platelet poor plasma;PPP 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验凝血功能;凝血功能试验;凝血过程;血液凝固;血液凝固功能;血液凝固过程因素存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）时刻;随机;随意;瞬间系数血小板因子 4 Ag 血栓细胞

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Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.