Version 2.77

Part Descriptions

LP175750-1   Ganglioside GM1
Ganglioside antibodies are associated with diverse peripheral neuropathies. Elevated antibody levels to ganglioside-monosialic acid (GM1) are associated with motor or sensorimotor neuropathies, particularly multifocal motor neuropathy. Anti-GM1 may occur as IgM (polyclonal or monoclonal) or IgG antibodies. These antibodies may also be found in patients with diverse connective tissue diseases as well as normal individuals. Source: ARUP Laboratories, GM1

LP175750-1   Ganglioside GM1
Gangliosides are molecules present on the plasma membrane of cells throughout the body and are especially prevalent in the nervous system, where they are involved in neuronal development and regeneration. Various gangliosides have been associated with different diseases. Both amyotrophic lateral sclerosis (ALS) and multifocal motor neuropathy (MMN) have been associated with anti-ganglioside antibodies. However, anti-GM1 antibodies are present in approximately 50% of patients with MMN and may be useful in distinguishing ALS from MMN. This distinction is important because in contrast to ALS, MMN responds to immunomodulatory treatment with intravenous immunoglobulins and when treated, does not decrease life expectancy. PMID: 25875836 Source: Regenstrief LOINC, PMID: 25875836

LP175750-1   Ganglioside GM1
Gangliosides are a family of molecules that are present throughout the body but especially prevalent in cells of the nervous system. Specific gangliosides are named for the carbohydrate sequence they contain and have a unique distribution within the nervous system. The oligosaccharide groups on gangliosides act as cell surface markers that play a role in cellular recognition and cell-to-cell communication, and they also act as specific receptors for certain pituitary glycoprotein hormones and certain bacterial protein toxins such as cholera toxin.
Anti-ganglioside antibodies, primarily IgG, are present in the sera from approximately 60% of patients with Guillain-Barré syndrome (GBS), and antibodies against different gangliosides are associated with different forms of GBS.
1. Antibodies against GD1a/GD1b and GD1b/GT1b complexes have been found in patients with more severe GBS requiring mechanical ventilation;
2. Antibodies against GM1 or those against GalNAc-GD1a have been associated with acute motor axonal neuropathy;
3. Anti-GQ1b antibodies are specifically associated with a variant of GBS called Fisher syndrome, which is characterized by ophthalmoplegia and ataxia.
Detection of specific markers early in the course of GBS may help guide the plan of care. PMID: 21214559 Source: Regenstrief LOINC, PMID: 2121455

LP36423-9   Ganglioside GM1
Gangliosides are a family of molecules that are present throughout the body but especially prevalent in cells of the nervous system. Specific gangliosides are named for the carbohydrate sequence they contain and have a unique distribution within the nervous system. The oligosaccharide groups on gangliosides act as cell surface markers that play a role in cellular recognition and cell-to-cell communication, and they also act as specific receptors for certain pituitary glycoprotein hormones and certain bacterial protein toxins such as cholera toxin.
Anti-ganglioside antibodies, primarily IgG, are present in the sera from approximately 60% of patients with Guillain-Barré syndrome (GBS), and antibodies against different gangliosides are associated with different forms of GBS.
1. Antibodies against GD1a/GD1b and GD1b/GT1b complexes have been found in patients with more severe GBS requiring mechanical ventilation;
2. Antibodies against GM1 or those against GalNAc-GD1a have been associated with acute motor axonal neuropathy;
3. Anti-GQ1b antibodies are specifically associated with a variant of GBS called Fisher syndrome, which is characterized by ophthalmoplegia and ataxia.
Detection of specific markers early in the course of GBS may help guide the plan of care. PMID: 21214559 Source: Regenstrief LOINC, PMID: 2121455

LP222219-0   Ganglioside
A ganglioside molecule consists of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acid residues linked to the sugar chain. Molecules with one sialic acid residue are called monosialogangliosides (GM), those with two are called disialogangliosides (GD), and those with three are trisialogangliosides (GT). Gangliosides without any sialic acid residues are called asialogangliosides, while those that do not have a ceramide N-acyl group are called lysogangliosides. The number that typically is included at the end of the name indicates the order in which the molecule was discovered. For example, GM2 is a ganglioside with one sialic acid residue that was the second GM to be identified. Source: Regenstrief LOINC

Fully-Specified Name

Component
Ganglioside GM1 Ab.IgG/Ganglioside GM1 Ab.IgM
Property
Ratio
Time
Pt
System
Ser
Scale
Qn
Method
IA

Additional Names

Short Name
GM1 Gangl IgG/IgM Ser IA-Rto
Display Name
Ganglioside GM1 IgG/IgM IA (S) [Ratio]
Consumer Name Alpha Get Info
Ganglioside GM1 IgG/IgM Antibody, Blood

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.22
Last Updated
Version 2.73
Change Reason
The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Observation
Common Test Rank Get Info
9040

Member of these Panels

LOINC Long Common Name
82455-7 Ganglioside Ab panel - Serum

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Gangliósido GM1 IgG/Gangliósido GM1 IgM:Fracción:Punto temporal:Suero:Qn:IA
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Gangliósido GM1 Ab.IgG / Gangliósido GM1 Ab.IgM:Proporción:Punto temporal:Suero:Cuantitativo:Inmunoensayo
fr-CA French (Canada) Ganglioside GM1 , IgG/Ganglioside GM1 , IgM:Ratios:Temps ponctuel:Sérum:Quantitatif:IA
fr-FR French (France) Ganglioside GM1 anticorps IgG/IgM:Ratio:Ponctuel:Sérum:Numérique:Immunoanalyse
it-IT Italian (Italy) Ganglioside GM1 Ab.IgG/Gangliosidi GM1 Ab.IgM:Rapporto:Pt:Siero:Qn:IA
Synonyms: Ab IgM ganglioside GM1 anticorpi IgG anticorpo Immunoassay Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) ganglioside GM1 As.IgG/ganglioside GM1 As.IgM:verhouding:moment:serum:kwantitatief:immunoassay
Synonyms: antistof; antilichaam IA
pt-BR Portuguese (Brazil) Gangliosideo GM1 Ac.IgG/Gangliosideo GM1 Ac.IgM:Ratio:Pt:Soro:Qn:Imunoensaio
Synonyms: Immune globulin M; Immunoglobulin M; Immune globulin G; Immunoglobulin G; GM1 Gangl; Rto; Point in time; Random; Serum; SR; Quantitative; QNT; Quant; Quan; Enzyme immunoassay; ELISA; MEIA; SUDS; ELFA; IAA; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; Serology
ru-RU Russian (Russian Federation) Ганглиозид GM1 Ат.IgG/Ганглиозид GM1 Ат.IgM:Отношение:ТчкВрм:Сыв:Колич:IA
Synonyms: Антитело Количественный Коэффициент;Соотношение;Пропорция Сыворотка Точка во времени;Момент
tr-TR Turkish (Turkey) Gangliozid GM1 Ab.IgG/Gangliozid GM1 Ab.IgM:Oran:Zmlı:Ser:Kant:İA
Synonyms: Ak Ak.IgG İmmünölçüm, immünoassay
zh-CN Chinese (China) 神经节苷脂 GM1 抗体.IgG/神经节苷脂 GM1 抗体.IgM:比率:时间点:血清:定量型:免疫测定法
Synonyms: Ab.IgG;IgG;抗体 IgG Ab;自身抗体 GM1;神经节糖苷 GM1 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 免疫球蛋白 G 免疫球蛋白 M 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 来自于不同体系的两个观察指标之比;比;比值 神经节糖苷 神经节苷脂 GM1 Ab 神经节苷脂 GM1 Ab.IgG 神经节苷脂 GM1 Ab.IgM 神经节苷脂 GM1 IgG 神经节苷脂 GM1 IgM 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目(非微生物学);血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验(非微生物学);血清学试验类 (非微生物学);血清类

Example Units

Unit Source
{Index_val} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=50770-7