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Part Description

LP69897-4   U1 small nuclear ribonucleoprotein 70kD
U1 small nuclear ribonucleoprotein particle (U1 snRNP) is an RNA-protein complex that is composed of ten proteins: U1-70kD, U1A, U1C and seven Smith antigen (Sm) proteins. The U1 snRNP complex is responsible for pre-mRNA processing. Autoantibodies to different components of the U1 snRNP complex are associated with autoimmune conditions including systemic lupus erythematosus (SLE) and mixed connective tissue disorders (MCTD), which includes systemic sclerosis. The pattern of autoantibodies present in an individual patient may help distinguish between different connective tissue disorders. For example, patients with anti-U1A and anti-U1C IgM antibodies are more likely to have SLE than MCTD. PMID: 24158973 In addition, there is some evidence that specific antibody patterns are associated with specific symptoms. For example, among patients with SLE, the combination of anti-U1-70kD, anti-U1A and anti-U1C correlates with Raynaud's phenomenon, while anti-U1-70kD and anti-U1A (without anti-U1C) correlate with leukopenia. Another study found an association between the number of specific positive antibodies within the anti-U1 snRNP (rather than the presence of particular markers) and certain clinical features. For example, patients with three or more positive autoantibodies were more likely to have features of systemic sclerosis and less likely to have renal disease compared to patients with fewer types of antibodies. PMID: 20015915 Source: Regenstrief LOINC, PMID: 24158973

LOINC Names Get Info

Fully-Specified Name
U1 small nuclear ribonucleoprotein 70kD Ab:PrThr:Pt:Ser:Ord:
Long Common Name
U1 small nuclear ribonucleoprotein 70kD Ab [Presence] in Serum
Short Name
U1 snRNP70 Ab Ser Ql
Display Name
U1 small nuclear ribonucleoprotein 70kD Ab Ql (S)
Consumer Name Alpha Get Info
U1 small nuclear ribonucleoprotein 70kD antibody, Blood

Part Model Get Info

  • Component
    U1 small nuclear ribonucleoprotein 70kD Ab
    LP69894-1
    • Analyte
      U1 small nuclear ribonucleoprotein 70kD Ab
      LP69894-1
      • Component Numerator
        U1 small nuclear ribonucleoprotein 70kD Ab
        LP69894-1
        • Component Numerator Core
          U1 small nuclear ribonucleoprotein 70kD
          LP69897-4
        • Component Numerator Core Suffix
          Ab
          LP20667-9
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    Ser
    LP7567-3
    • System Core
      Ser
      LP7567-3
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    NULL
     

Example Answer List: LL360-9

Source: Regenstrief Institute
AnswerCodeScoreAnswer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)LA6577-6

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.24
Last Updated
Version 2.56 (MIN)
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Member of these Groups Get Info

LOINC GroupGroup Name
LG21400-3U1 small nuclear ribonucleoprotein 70kD Ab|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)U1 malý jaderný ribonukleoprotein 70kD Ab:Přítomnost nebo práh:Časový bod:Sérum:Ordinální:
de-ATGerman (Austria)Synonyms: U1-snRNP-70-AK ql.
de-DEGerman (Germany)U1 kleines nukleäre Ribonukleoprotein 70kD Ak:Nachweis oder Schwellenwert:Zeitpunkt:Serum:Ordinal:
el-GRGreek (Greece)Μικρή πυρηνική ριβονουκλεοπρωτεΐνη 70kD Αντίσωμα:PrThr:Pt:Ορός:Ord:
Synonyms: Ord PrThr Pt SERO Αντίσωμα Μικρή πυρηνική ριβονουκλεοπρωτεΐνη 70kD Μικρή πυρηνική ριβονουκλεοπρωτεΐνη U1 Ορός Πυρηνικό
es-ESSpanish (Spain)U1 ribonucleoproteína nuclear pqueña de 70kD Anticuerpos:PrThr:Punto temporal:Suero:Ord:
es-MXSpanish (Mexico)Ribonucleoproteína nuclear sub U1 70kD Ab:Presencia o umbral:Punto temporal:Suero:Ordinal:
fr-CAFrench (Canada)Petite particule nucléaire ribonucléoprotéique U1 70kD, Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:
fr-FRFrench (France)RNP 70kD Ac:Présence/Seuil:Ponctuel:Sérum:Qualitatif:
fr-BEFrench (Belgium)Petite particule nucléaire ribonucléoprotéique U1 70kD Ac:PrThr:Temps ponctuel:Sérum:Ordinal:
Synonyms: Anticorps
it-ITItalian (Italy)U1, piccola ribonucleoproteina nucleare 70kD Ab:PrThr:Pt:Siero:Ord:
Synonyms: anticorpo Piccola ribonucleoproteina nucleare U1 Piccola ribonucleoproteina nucleare U1 70kD Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NLDutch (Netherlands)u1 small nucleair ribonucleoproteïne 70kD As:aanwezigheid:moment:serum:ordinaal:
Synonyms: antistof; antilichaam
pl-PLPolish (Poland)U1 mała jądrowa nukleoproteina 70kDa Ab:granica wykrywalności:punkt w czasie:surowica:uporządkowany:
Synonyms: Mała rybonukleoproteina jądrowa U1 U1-snRNP 70 kDa
pt-BRPortuguese (Brazil)U1 Ribonucleoproteína núcleo pequeno 70kD Ac.IgG:ACnc:Pt:Soro:Ord:
Synonyms: ; U1 snRNP 70kD; U1 RNP; U1RNP; Nuc; Arbitrary concentration; Point in time; Random; Serum; SR; Ql; Ordinal; QL; Qualitative; Qual; Screen; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; Ribonuclear protein; Serology
ru-RURussian (Russian Federation)U1 малый ядерный рибонуклеопротеин 70кД Ат:PrThr:ТчкВрм:Сыв:Пор:
Synonyms: Антитело Порядковый Сыворотка Точка во времени;Момент
tr-TRTurkish (Turkey)U1 kçk nükleer ribonükleoprotein 70kD Ab:MevcEşik:Zmlı:Ser:Srl:
Synonyms: Ak Çekirdek Mevcut
zh-CNChinese (China)U1 小细胞核核糖核蛋白 70kD 抗体:存在情况或阈值:时间点:血清:序数型:
Synonyms: Ab;自身抗体 RNP snRNP U1 RNP 70kD;U1 snRNP 70kD;U1 小细胞核核糖核蛋白 70kD;U1 small nuclear ribonucleoprotein 70kD;U1RNP 70kD U1 RNP;U1 snRNP;U1 小细胞核核糖核蛋白;U1 small nuclear ribonucleoprotein;U1RNP 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 小分子核糖核蛋白体 小分子细胞核核糖核蛋白 小核核糖核蛋白（Small nuclear ribonucleoprotein，snRNP） 时刻;随机;随意;瞬间 核;胞核 核内小核糖核蛋白 核微小核糖核蛋白 核糖核蛋白（Ribonucleoprotein，Ribonuclear protein，RNP） 核蛋白 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=53032-9