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Part Descriptions

LP15684-1   Kynurenate
Kynurenic acid (KYNA) is a product of the normal metabolism of amino acid L-tryptophan. It has been shown that kynurenic acid possesses neuroactive activity. It acts as an antiexcitotoxic and anticonvulsant, most likely through acting as an antagonist at excitatory amino acid receptors. Because of this activity, it may influence important neurophysiologic and neuropathologic processes. As a result, kynurenic acid has been considered for use in therapy in certain neurobiological disorders. Conversely, increased levels of kynurenic acid have also been linked to certain pathological conditions.

High levels of kynurenic acid have been identified in patients suffering from tick-borne encephalitis, schizophrenia and HIV-related illnesses. In all these situations increased levels were associated with confusion and psychotic symptoms. Kynurenic acid acts in the brain as a glycine-site NMDAr antagonist, key in glutamatergic neurotransmission system, which is thought to be involved in the pathophysiology and pathogenesis of schizophrenia.

A kynurenic acid hypothesis of schizophrenia has been proposed in 2007, based on its action on midbrain dopamine activity and NMDArs, thus linking dopamine hypothesis of schizophrenia with the glutamate hypothesis of the disease.

High levels of kynurenic acid have been identified in human urine in certain metabolic disorders, such as marked pyridoxine deficiency and deficiency/absence of kynureninase. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Kynurenic acid

LP32035-5   Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Creatinine

LOINC Names Get Info

Fully-Specified Name
Kynurenate/Creatinine:SRto:Pt:Urine:Qn:
Long Common Name
Kynurenate/Creatinine [Molar ratio] in Urine
Short Name
KYN/Creat Ur-sRto
Display Name
Kynurenate/Creatinine (U) [Molar ratio]
Consumer Name Alpha Get Info
Kynurenate/Creatinine, Urine

Part Model Get Info

  • Component
    Kynurenate/Creatinine
    LP286324-1
    • Analyte
      Kynurenate/Creatinine
      LP286324-1
      • Component Numerator
        Kynurenate
        LP15684-1
        • Component Numerator Core
          Kynurenate
          LP15684-1
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        Creatinine
        LP32035-5
        • Component Denominator Core
          Creatinine
          LP32035-5
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    SRto
    LP6868-6
  • Time
    Pt
    LP6960-1
  • System
    Urine
    LP7681-2
    • System Core
      Urine
      LP7681-2
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    NULL
     

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.24
Last Updated
Version 2.75 (MIN)
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Kynurenát/kreatinin:Látkový poměr:Časový bod:Moč:Kvantitativní:
el-GRGreek (Greece)Κυνουρενάτη/Κρεατινίνη:SRto:Pt:Ούρα:Qn:
Synonyms: CHEM Pt Qn SRto Κρεατινίνη Κυνουρενάτη Ούρα
es-ESSpanish (Spain)Quinurenato/Creatinina:Relacion de Sustancia:Punto temporal:Orina:Qn:
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Quinurenato / creatinina:Proporción de sustancia:Punto temporal:Orina:Cuantitativo:
fr-CAFrench (Canada)Kynurénate/Créatinine:Ratio de substance:Temps ponctuel:Urine:Quantitatif:
fr-FRFrench (France)Cynurénate/créatinine:Moles ratio:Ponctuel:Urine:Numérique:
fr-BEFrench (Belgium)Kynurénate/Créatinine:Ratio de substance:Temps ponctuel:Urine:Quantitatif:
it-ITItalian (Italy)Chinurenato/Creatinina:Srto:Pt:Urine:Qn:
Synonyms: Chimica Punto nel tempo (episodio) Rapporto di sostanza
nl-NLDutch (Netherlands)kynurenaat/creatinine:molaire verhouding:moment:urine:kwantitatief:
Synonyms: kreatinine
pt-BRPortuguese (Brazil)Kynurenate/Creatinina:SCrto:Pt:Urina:Qn:
Synonyms: ; Kynuren; KYN; KYNA; Kynurenic acid; Creat; CR; sRto; Substance concentration ratio; Point in time; Random; Ur; UR; Urn; UA; Quantitative; QNT; Quant; Quan; Chemistry; UCr
ru-RURussian (Russian Federation)Кинуренат/Креатинин:МольОтн:ТчкВрм:Моча:Колич:
Synonyms: Количественный Мольная доля;Молярная доля;Отношение концентраций Точка во времени;Момент
tr-TRTurkish (Turkey)Kinirenat/Kreatinin:SOrn:Zmlı:İdrar:Kant:
Synonyms: SubsOranı
zh-CNChinese (China)犬尿氨酸/肌酐:物质的量比率:时间点:尿液:定量型:
Synonyms: CR;Creat;肌氨酸酐;肌酸内酰胺;肌酸酐 KYN;KYNA;犬尿氨酸（Kynurenic acid，KYNA） UCr 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 尿;小便;下泉 尿液肌酐 尿液肌酸酐 尿肌酸酐 时刻;随机;随意;瞬间 物质的量比值;物质的量比;摩尔比;摩尔比率;摩尔比值 肌酸内酰胺

Example Units

UnitSource
nmol/mmol{creat}Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=53107-9