53107-9
Kynurenate/Creatinine [Molar ratio] in Urine
Active
Part Descriptions
LP15684-1 Kynurenate
Kynurenic acid (KYNA) is a product of the normal metabolism of amino acid L-tryptophan. It has been shown that kynurenic acid possesses neuroactive activity. It acts as an antiexcitotoxic and anticonvulsant, most likely through acting as an antagonist at excitatory amino acid receptors. Because of this activity, it may influence important neurophysiologic and neuropathologic processes. As a result, kynurenic acid has been considered for use in therapy in certain neurobiological disorders. Conversely, increased levels of kynurenic acid have also been linked to certain pathological conditions.
High levels of kynurenic acid have been identified in patients suffering from tick-borne encephalitis, schizophrenia and HIV-related illnesses. In all these situations increased levels were associated with confusion and psychotic symptoms. Kynurenic acid acts in the brain as a glycine-site NMDAr antagonist, key in glutamatergic neurotransmission system, which is thought to be involved in the pathophysiology and pathogenesis of schizophrenia.
A kynurenic acid hypothesis of schizophrenia has been proposed in 2007, based on its action on midbrain dopamine activity and NMDArs, thus linking dopamine hypothesis of schizophrenia with the glutamate hypothesis of the disease.
High levels of kynurenic acid have been identified in human urine in certain metabolic disorders, such as marked pyridoxine deficiency and deficiency/absence of kynureninase.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia, Kynurenic acid
LP32035-5 Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas.
Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.)
Source: Human Metabolome Database, Creatinine
Fully-Specified Name
- Component
- Kynurenate/Creatinine
- Property
- SRto
- Time
- Pt
- System
- Urine
- Scale
- Qn
- Method
Additional Names
- Short Name
- KYN/Creat Ur-sRto
- Display Name
- Kynurenate/Creatinine (U) [Molar ratio]
- Consumer Name Alpha Get Info
- Kynurenate/Creatinine, Urine
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.24
- Last Updated
- Version 2.75
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Quinurenato/Creatinina: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Quinurenato / creatinina: |
| fr-CA | French (Canada) | Kynurénate/Créatinine: |
| fr-FR | French (France) | Cynurénate/créatinine: |
| fr-BE | French (Belgium) | Kynurénate/Créatinine: |
| it-IT | Italian (Italy) | Chinurenato/Creatinina: Synonyms: Chimica Punto nel tempo (episodio) Rapporto di sostanza |
| nl-NL | Dutch (Netherlands) | kynurenaat/creatinine: Synonyms: kreatinine |
| pt-BR | Portuguese (Brazil) | Kynurenate/Creatinina: Synonyms: ; |
| ru-RU | Russian (Russian Federation) | Кинуренат/Креатинин: Synonyms: Количественный Мольная доля; |
| tr-TR | Turkish (Turkey) | Kinirenat/Kreatinin: Synonyms: SubsOranı |
| zh-CN | Chinese (China) | 犬尿氨酸/肌酐: Synonyms: CR; |
Example Units
| Unit | Source |
|---|---|
| nmol/mmol{creat} | Example UCUM Units |
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