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Part Description

LP15684-1   Kynurenate
Kynurenic acid (KYNA) is a product of the normal metabolism of amino acid L-tryptophan. It has been shown that kynurenic acid possesses neuroactive activity. It acts as an antiexcitotoxic and anticonvulsant, most likely through acting as an antagonist at excitatory amino acid receptors. Because of this activity, it may influence important neurophysiologic and neuropathologic processes. As a result, kynurenic acid has been considered for use in therapy in certain neurobiological disorders. Conversely, increased levels of kynurenic acid have also been linked to certain pathological conditions.

High levels of kynurenic acid have been identified in patients suffering from tick-borne encephalitis, schizophrenia and HIV-related illnesses. In all these situations increased levels were associated with confusion and psychotic symptoms. Kynurenic acid acts in the brain as a glycine-site NMDAr antagonist, key in glutamatergic neurotransmission system, which is thought to be involved in the pathophysiology and pathogenesis of schizophrenia.

A kynurenic acid hypothesis of schizophrenia has been proposed in 2007, based on its action on midbrain dopamine activity and NMDArs, thus linking dopamine hypothesis of schizophrenia with the glutamate hypothesis of the disease.

High levels of kynurenic acid have been identified in human urine in certain metabolic disorders, such as marked pyridoxine deficiency and deficiency/absence of kynureninase. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Kynurenic acid

LOINC Names Get Info

Fully-Specified Name
Kynurenate:SRat:24H:Urine:Qn:
Long Common Name
Kynurenate [Moles/time] in 24 hour Urine
Short Name
KYN 24h Ur-sRate
Display Name
Kynurenate (24H U) [Moles/Time]
Consumer Name Alpha Get Info
Kynurenate, Urine

Part Model Get Info

  • Component
    Kynurenate
    LP15684-1
    • Analyte
      Kynurenate
      LP15684-1
      • Component Numerator
        Kynurenate
        LP15684-1
        • Component Numerator Core
          Kynurenate
          LP15684-1
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    SRat
    LP6867-8
  • Time
    24H
    LP6924-7
  • System
    Urine
    LP7681-2
    • System Core
      Urine
      LP7681-2
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    NULL
     

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.26
Last Updated
Version 2.75 (MIN)
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Kynurenát:Látkový tok:24 hodin:Moč:Kvantitativní:
el-GRGreek (Greece)Κυνουρενάτη:SRat:24H:Ούρα:Qn:
Synonyms: 24H CHEM Qn SRat Κυνουρενάτη Ούρα
es-MXSpanish (Mexico)Quinurenato:Tasa de sustancia:24H:Orina:Cuantitativo:
es-ESSpanish (Spain)Quinurenato:Indice de susbtancia:24 horas:Orina:Qn:
Synonyms: Cuantitativo
fr-CAFrench (Canada)Kynurénate:Débit de substance:24 h:Urine:Quantitatif:
fr-FRFrench (France)Cynurénate:Moles/Temps:24H:Urine:Numérique:
fr-BEFrench (Belgium)Kynurénate:Débit de substance:24 h:Urine:Quantitatif:
it-ITItalian (Italy)Chinurenato:SRat:24h:Urine:Qn:
Synonyms: 24 Ore Chimica Tasso di sostanza
nl-NLDutch (Netherlands)kynurenaat:mol/tijd:24 uur:urine:kwantitatief:
Synonyms: 24U
pt-BRPortuguese (Brazil)Kinurenato:SRat:24H:Urina:Qn:
Synonyms: ; Kynuren; KYN; KYNA; Kynurenic acid; sRate; Substance rate; 1 day; 24 hours; 24HR; Ur; UR; Urn; UA; Quantitative; QNT; Quant; Quan; Chemistry
ru-RURussian (Russian Federation)Кинуренат:МольРасх:24 часа:Моча:Колич:
Synonyms: Количественный Молярная скорость;Молярный расход
tr-TRTurkish (Turkey)Kinirenat:SubHz:24Sa:İdrar:Kant:
zh-CNChinese (China)犬尿氨酸:物质的量速率:24小时:尿液:定量型:
Synonyms: 1天;1日;24.0小时;一天;一日;二十四个小时;二十四小时 KYN;KYNA;犬尿氨酸（Kynurenic acid，KYNA） 克分子速率;克分子速率(单位时间);摩尔速率;摩尔速率(单位时间);物质的量速率(单位时间) 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 尿;小便;下泉

Example Units

UnitSource
nmol/(24.h)Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=53489-1