Version 2.80

Part Description

LP19749-8   NRAS gene
The NRAS gene (neuroblastoma RAS viral (v-ras) oncogene homolog) [HGNC Gene ID:7989] is located on chromosome 1p13.2. This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011] [NCBI Gene ID:4893] Source: National Center for Biotechnology Information (NCBI) Gene

Fully-Specified Name

Component
NRAS gene targeted mutation analysis
Property
Prid
Time
Pt
System
Bone mar
Scale
Nom
Method
Molgen

Additional Names

Long Common Name
NRAS gene mutations found [Identifier] in Bone marrow by Molecular genetics method Nominal
Short Name
NRAS gene Mut Anl Mar
Display Name
NRAS gene targeted mutation analysis Molgen Nom (BM)
Consumer Name Alpha Get Info
NRAS gene targeted mutation analysis, Bone marrow

Basic Attributes

Class
MOLPATH.MUT
Type
Laboratory
First Released
Version 2.26
Last Updated
Version 2.73 (MIN)
Change Reason
Based on LOINC Committee review (June 2016), "targeted" was added to the Component to clarify that this test is looking for a specific set of mutations as described in the LOINC User Guide under the Molecular Genetics section.
Order vs. Observation
Both
Common Test Rank Get Info
17011

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: NRAS Genmutation /KM
el-GR Greek (Greece) Γονίδιο NRAS στοχευμένη ανάλυση μεταλλάξεων:Prid:Pt:Μυελός των οστών:Nom:Μοριακή γενετική
Synonyms: Prid Γονίδιο Γονίδιο NRAS
es-ES Spanish (Spain) Gen NRAS Analisis de mutaciones:Presencia o identidad:Punto temporal:Médula ósea:Nom:Genética molecular
es-MX Spanish (Mexico) Análisis de mutaciones dirigidas al gen NRAS:Presencia o identidad:Punto temporal:Médula ósea:Nominal:Genética molecular
fr-FR French (France) NRAS gène mutation cible trouvée:Identification:Ponctuel:Moelle osseuse:Résultat nominal:Biologie moléculaire
it-IT Italian (Italy) NRAS, gene analisi di mutazione mirata:Prid:Pt:Mid oss:Nom:Molgen
Synonyms: Gene NRAS Genetica molecolare Midollo osseo Mutazione genica Patologia molecolare Presenza o Identità Punto nel tempo (episodio)
nl-NL Dutch (Netherlands) NRAS-gen doelgerichte mutatie-analyse:identificator:moment:beenmerg:nominaal:moleculair genetisch onderzoek
Synonyms: molgen NRAS gen targeted
pt-BR Portuguese (Brazil) NRAS análise de mutação genética:Ident:Pt:MedOssea:Nom:Genética molecular
Synonyms: Oncogene NRAS; v-ras neuroblastoma RAS viral oncogene homolog; Identity or presence; Point in time; Random; BM; Bone marrow; BON; Nominal; PCR; Molecular genetics; Mut Anal; Mutations; MOLPATH.MUTATIONS; MOLPATH.MUTATIONS; Molecular pathology
ru-RU Russian (Russian Federation) NRAS ген исследование на мутацию:ПрИд:ТчкВрм:Костный мозг:Ном:МолГен
Synonyms: Номинальный;Именной Присутствие или Идентификация Точка во времени;Момент
tr-TR Turkish (Turkey) NRAS geni Mutasyon analizi:MevcKimlik:Zmlı:Kem il:Snf:Molgen
zh-CN Chinese (China) NRAS 基因 突变分析:存在与否或特征标识:时间点:骨髓:名义型:分子遗传学类实验室方法
Synonyms: v-ras 成神经细胞瘤 RAS 病毒癌基因同源基因;v-ras 神经母细胞瘤 RAS 病毒癌基因同源基因;癌基因 NRAS;致癌基因 NRAS 分子病理学.基因突变;分子病理学.突变;分子病理学试验.基因突变;分子病理学试验.突变;分子病理学试验类.突变;基因突变;突变 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 基因突变分析 存在;存在与否;特征标识;身份;身份标识 时刻;随机;随意;瞬间 遗传基因;遗传因子;吉恩;生物基因 骨骼;骨头 髓

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=53621-9