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Term Description

Glial Nuclear Antibody (AGNA) Type 1 antibody is a marker found in paraneoplastic syndrome associated with small cell lung carcinoma (SCLC). It is also closely associated with paraneoplastic Lambert-Eaton Myasthenia Syndrome (LEMS). There appears to be a tight association between AGNA and voltage-gated calcium channel antibodies in patients with SCLC. Patients with AGNA have characteristic nuclear staining of the Bergmann glia in the Purkinje cell layer of the cerebellum. Information from "Paraneoplastic limbic encephalitis associated with potassium channel antibodies: value of anti-glial nuclear antibodies in identifying the tumour" by L. Zuliani, A. Saiz, B. Tavolato, B. Giometto, A. Vincent and Francesc Graus, JNNPm 2007; 78; p. 204-205.

Part Description

LP71299-9   Glial nuclear type 1
Anti-glial nuclear antibody type 1 (AGNA-1) targets the Sox1 nuclear antigen found in Bergmann cells, a specialized glial cell type found in the cerebellar cortex. AGNA-1 antibodies are associated with paraneoplastic Lambert-Eaton myasthenic syndrome (LEMS) and paraneoplastic neuropathies associated with small cell lung cancer (SCLC). They have also been associated with non-paraneoplastic neuropathy, which may be an immune-mediated condition. PMID: 20701982 Source: Regenstrief LOINC, PMID: 20701982

LOINC Names Get Info

Fully-Specified Name
Glial nuclear type 1 Ab:Titr:Pt:Ser:SemiQn:
Long Common Name
Glial nuclear type 1 Ab [Titer] in Serum
Short Name
Glial nuc type 1 Ab Titr Ser
Display Name
Glial nuclear type 1 Ab (S) [Titer]
Consumer Name Alpha Get Info
Glial nuclear type 1 antibody, Blood

Part Model Get Info

  • Component
    Glial nuclear type 1 Ab
    LP70985-4
    • Analyte
      Glial nuclear type 1 Ab
      LP70985-4
      • Component Numerator
        Glial nuclear type 1 Ab
        LP70985-4
        • Component Numerator Core
          Glial nuclear type 1
          LP71299-9
        • Component Numerator Core Suffix
          Ab
          LP20667-9
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Titr
    LP6881-9
  • Time
    Pt
    LP6960-1
  • System
    Ser
    LP7567-3
    • System Core
      Ser
      LP7567-3
    • Super System
      NULL
       
  • Scale
    SemiQn
    LP436123-6
  • Method
    NULL
     

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.26
Last Updated
Version 2.75 (MAJ)
Order vs. Observation
Both
Common Test Rank Get Info
2636

Member of these Panels

LOINCLong Common Name
43104-9Paraneoplastic Ab panel - Serum

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Antinukleární protilátky gliální typ 1:Arbitrární koncentrace (titr):Časový bod:Sérum:Semikvantitativní:
de-ATGerman (Austria)Synonyms: Anti-SOX1 (AGNA)
el-GRGreek (Greece)Γλοιακός πυρηνικός τύπος 1 Αντίσωμα:Titr:Pt:Ορός:Ημιποσοτική:
Synonyms: Pt SERO Titr Type Αντίσωμα Γλοιακός πυρηνικός τύπος 1 Ημιποσοτική Ορός Πυρηνικό
es-ESSpanish (Spain)Gliales de tipo nuclear 1 Anticuerpos:Titulo / Factor de dilución:Punto temporal:Suero:Semicuantitativo:
Synonyms: Semicuantitativo
es-MXSpanish (Mexico)Glial nuclear tipo 1 Ab:Título:Punto temporal:Suero:Cuantitativo:
fr-CAFrench (Canada)Gliale nucléaire de type 1, Ac:Titre:Temps ponctuel:Sérum:SemiQn:
fr-FRFrench (France)Noyau cellule gliale type 1 Ac:Titre:Ponctuel:Sérum:Semi-Quantitatif:
it-ITItalian (Italy)Gliali di tipo nucleare 1 Ab:Titr:Pt:Siero:SemiQn:
Synonyms: anticorpo Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant Titolo
nl-NLDutch (Netherlands)gliaal nucleair type 1 As:titer:moment:serum:semikwantitatief:
Synonyms: antistof; antilichaam soort
pl-PLPolish (Poland)Glejowy typ jądrowy 1 Ab:miano:punkt w czasie:surowica:półilościowy:
Synonyms: Anty-glejowe jądrowe typu 1 Ab
pt-BRPortuguese (Brazil)Glial nuclear tipe 1 Ac:Título:Pt:Soro:Qn:
Synonyms: Nuc; Dilution factor; Titer; Titre; Ttr; Titered; Point in time; Random; Serum; SR; Quantitative; QNT; Quant; Quan; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; I; Serology
zh-CNChinese (China)神经胶质细胞核 1 型 抗体:滴定度:时间点:血清:半定量型:
Synonyms: Ⅰ Ab;自身抗体 I 型 效价;滴定浓度;滴定率;滴定量;滴度;稀释倍数;稀释因子;稀释系数 时刻;随机;随意;瞬间 核;胞核 神经胶质细胞核类型 1;神经胶质细胞核 I 型 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Example Units

UnitSource
titerREGENSTRIEF
{titer}Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=53709-2