Version 2.78

Term Description

Glial Nuclear Antibody (AGNA) Type 1 antibody is a marker found in paraneoplastic syndrome associated with small cell lung carcinoma (SCLC). It is also closely associated with paraneoplastic Lambert-Eaton Myasthenia Syndrome (LEMS). There appears to be a tight association between AGNA and voltage-gated calcium channel antibodies in patients with SCLC. Patients with AGNA have characteristic nuclear staining of the Bergmann glia in the Purkinje cell layer of the cerebellum. Information from "Paraneoplastic limbic encephalitis associated with potassium channel antibodies: value of anti-glial nuclear antibodies in identifying the tumour" by L. Zuliani, A. Saiz, B. Tavolato, B. Giometto, A. Vincent and Francesc Graus, JNNPm 2007; 78; p. 204-205.
Source: Regenstrief LOINC

Part Description

LP71299-9   Glial nuclear type 1
Anti-glial nuclear antibody type 1 (AGNA-1) targets the Sox1 nuclear antigen found in Bergmann cells, a specialized glial cell type found in the cerebellar cortex. AGNA-1 antibodies are associated with paraneoplastic Lambert-Eaton myasthenic syndrome (LEMS) and paraneoplastic neuropathies associated with small cell lung cancer (SCLC). They have also been associated with non-paraneoplastic neuropathy, which may be an immune-mediated condition. PMID: 20701982 Source: Regenstrief LOINC, PMID: 20701982

Fully-Specified Name

Component
Glial nuclear type 1 Ab
Property
Titr
Time
Pt
System
Ser
Scale
SemiQn
Method

Additional Names

Short Name
Glial nuc type 1 Ab Titr Ser
Display Name
Glial nuclear type 1 Ab (S) [Titer]
Consumer Name Alpha Get Info
Glial nuclear type 1 antibody, Blood

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.26
Last Updated
Version 2.75
Order vs. Observation
Both
Common Test Rank Get Info
2636

Member of these Panels

LOINC Long Common Name
43104-9 Paraneoplastic Ab panel - Serum

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: Anti-SOX1 (AGNA)
es-ES Spanish (Spain) Gliales de tipo nuclear 1 Anticuerpos:Titulo / Factor de dilución:Punto temporal:Suero:Semicuantitativo:
Synonyms: Semicuantitativo
es-MX Spanish (Mexico) Glial nuclear tipo 1 Ab:Título:Punto temporal:Suero:Cuantitativo:
fr-CA French (Canada) Gliale nucléaire de type 1, Ac:Titre:Temps ponctuel:Sérum:SemiQn:
fr-FR French (France) Noyau cellule gliale type 1 anticorps:Titre:Ponctuel:Sérum:Semi-Quantitatif:
it-IT Italian (Italy) Gliali di tipo nucleare 1 Ab:Titr:Pt:Siero:SemiQn:
Synonyms: anticorpo Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant Titolo
nl-NL Dutch (Netherlands) gliaal nucleair type 1 As:titer:moment:serum:semikwantitatief:
Synonyms: antistof; antilichaam soort
pt-BR Portuguese (Brazil) Glial nuclear tipe 1 Ac:Título:Pt:Soro:Qn:
Synonyms: Nuc; Dilution factor; Titer; Titre; Ttr; Titered; Point in time; Random; Serum; SR; Quantitative; QNT; Quant; Quan; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; I; Serology
zh-CN Chinese (China) 神经胶质细胞核 1 型 抗体:滴定度:时间点:血清:半定量型:
Synonyms: Ⅰ Ab;自身抗体 I 型 效价;滴定浓度;滴定率;滴定量;滴度;稀释倍数;稀释因子;稀释系数 时刻;随机;随意;瞬间 核;胞核 神经胶质细胞核类型 1;神经胶质细胞核 I 型 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Example Units

Unit Source
titer REGENSTRIEF
{titer} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=53709-2