Version 2.77

Part Descriptions

LP16098-3   cycloSPORINE
Cyclosporine (Brand names Neoral, Restasis, Sandimmune, Gengraf) is a cyclic undecapeptide of fungal origin and a potent calcineurin inhibitor immunosuppressive agent. The introduction of cyclosporine in human organ transplantation substantially improved patient and graft survival in patients receiving heart, kidney, liver, pancreas, lung or bone marrow transplants. Cyclosporine was the first drug to specifically and reversibly inhibit the activation and proliferation of lymphocytes. The main mechanism through which cyclosporine exerts its immunosuppressive effect is the inhibition of T cell activation and proliferation. Monitoring and concentration-controlled dosing is required to maintain patient drug levels within a narrow therapeutic window; low levels could cause transplant rejection and high levels may cause nephrotoxicity. PMID: 19545653 Source: Regenstrief LOINC, PMID: 19545653

LP20176-1   trough
In medicine, a trough level is the lowest level that a medicine is present in the body. In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing. It should be contrasted with a "peak level", which is the highest level of the medicine in the body, and the "average level", which is the mean level over time. It helps in therapeutic drug monitoring. It is widely used in clinical trials for newer medicines for its therapeutic effectiveness and safety. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Trough levels for therapeutic drug monitoring

Fully-Specified Name

Component
cycloSPORINE^trough
Property
MCnc
Time
Pt
System
Bld
Scale
Qn
Method

Additional Names

Short Name
cycloSPORINE Trough Bld-mCnc
Display Name
cycloSPORINE trough (Bld) [Mass/Vol]
Consumer Name Alpha Get Info
cycloSPORINE trough, Blood

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.26
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
6515

Member of these Groups Get Info

LOINC Group Group Name
LG19342-1 Cyclosporine^trough|MCnc|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Κυκλοσπορίνη^κατώτερα επίπεδα:Συγκέντρωση μάζας:Χρονική στιγμή:Αίμα:Ποσοτική:
es-ES Spanish (Spain) Ciclosporina^Valle monitorización terapéutica de fármacos:Concentración de masa:Punto temporal:Sangre:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) cicloesporino ^ canal:Concentración de masa:Punto temporal:Sangre:Cuantitativo:
et-EE Estonian (Estonia) Tsüklosporiin^baas:MCnc:Pt:B:Qn:
Synonyms: Juhuslik Kvantitatiivne Veri
fr-CA French (Canada) Cyclosporine^Creux:Concentration de masse:Temps ponctuel:Sang:Quantitatif:
fr-FR French (France) Ciclosporine taux résiduel:Masse/Volume:Ponctuel:Sang:Numérique:
fr-BE French (Belgium) Cyclosporine^Creux:Concentration de masse:Temps ponctuel:Sang:Quantitatif:
Synonyms: Minimum, nadir
it-IT Italian (Italy) Ciclosporina^valore minimo:MCnc:Pt:Sangue:Qn:
Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Punto nel tempo (episodio) Sangue valore minimo TDM
nl-NL Dutch (Netherlands) ciclosporine^dalspiegel:massa/volume:moment:bloed:kwantitatief:
pt-BR Portuguese (Brazil) Ciclosporina^basal:MCnc:Pt:SgTotal:Qn:
Synonyms: ; Cyclosporin; Cyclosporins; CsA; Ciclosporin; Ciclosporine; Neoral; SangCya; Cyclosporin a; Sandimmune; Pre; Predose; Pre-dose; Mass concentration; Level; Point in time; Random; Blood; WB; Whole blood; Quantitative; QNT; Quant; Quan; Drugs; DRUG/TOXICOLOGY; DRUG/TOXICOLOGY
ru-RU Russian (Russian Federation) Циклоспорин^остаточная концентрация:МассКонц:ТчкВрм:Кр:Колич:
Synonyms: Количественный Кровь Массовая концентрация минимум концентрации Точка во времени;Момент
tr-TR Turkish (Turkey) Siklosporin^en düşük:KütlKons:Zmlı:Kan:Kant:
Synonyms: çukur düzey
zh-CN Chinese (China) 环孢菌素^波谷:质量浓度:时间点:全血:定量型:
Synonyms: 一剂药物的初始剂量;初始剂量;剂量药物的初始剂量;前剂量;曲线上的最小值;最低点;本底剂量;治疗药物监测 - 波谷;预剂量 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 毒品 毒品类 水平;浓度;质量浓度(单位体积) 环孢霉素A; 山地明环孢灵; 环孢多肽A; 环孢素; 赛斯平; 环孢菌素; 环孢菌素A; 环孢素A;山地明;环孢多肽;环孢抑制剂;环孢灵;环孢霉素;环孢霉素A;环孢素;Cyclosporine;Cyclosporin; Restasis; Cyclosporine A; cyclosporin A; Antibiotic S 7481F1; 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonameth 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 血;血液

Example Units

Unit Source
ng/mL REGENSTRIEF
ug/L Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=53828-0