Version 2.78

Part Description

LP65748-3   HIV 1 tropism
HIV enters cells by attaching first to the CD4 receptor and then to either the CCR5 or CXCR4 molecules, followed by fusion of the viral and cellular membranes. CCR5 coreceptor antagonists prevent HIV entry into target cells by binding to the CCR5 receptors. HIV tropism assays determine whether the HIV binds to CCR5, CXCR4 or both. An HIV tropism assay should be performed whenever the use of a CCR5 antagonist is being considered or a patient has virologic failure on a CCR5 antagonist.
During acute or recent infection, the vast majority of patients harbor a CCR5-binding virus (called R5 tropism), which suggests that the R5 variant is preferentially transmitted. Viruses in many untreated patients exhibit a shift in co-receptor tropism from CCR5 usage to either CXCR4 (X4 tropism) or both (D/M-tropic, which stands for dual or mixed), which is associated with a more rapid decline in CD4 T-cell counts. Patients who have been treated with anti-retroviral drugs and who have extensive drug resistance are more likely to harbor X4- or D/M-tropic variants than untreated patients with comparable CD4 counts. The prevalence of X4- or D/M-tropic variants increases to more than 50% in treated patients who have CD4 counts <100 cells/mm3. [https://aidsinfo.nih.gov/contentfiles/lvguidelines/adultandadolescentgl.pdf] Source: Regenstrief LOINC, NIH adult and adolescent HIV guidelines

Fully-Specified Name

Component
HIV 1 tropism
Property
Prid
Time
Pt
System
Bld
Scale
Nar
Method

Additional Names

Short Name
HIV1 tropism Bld
Display Name
HIV 1 tropism Nar (Bld)
Consumer Name Alpha Get Info
HIV 1 tropism, Blood

Example Answer List: LL2265-8

Source: Regenstrief LOINC
Answer Code Score Answer ID
R5

Viruses or virus populations that use only the CCR5 chemokine co-receptor to infect CD4+ cells.

 LA19204-9
X4

Viruses or virus populations that use only the CXCR4 chemokine co-receptor to infect CD4+ cells.

 LA19205-6
D/M

Dual (D)-tropic: Viruses or virus populations that can use either the CCR5 or CXCR4 co-receptors to infect CD4+ cells. Mixed (M)-tropic: Virus populations that may contain various combinations of R5 virus, X4 virus, and/or dual-tropic viruses

 LA19206-4

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.26
Last Updated
Version 2.73
Change Reason
Changed long common name from 'HIV 1 tropism [Identifier] in Blood' to add that answers were narrative.
Order vs. Observation
Both
Common Test Rank Get Info
10401

Member of these Panels

LOINC Long Common Name
75622-1 HIV 1 and 2 tests - Meaningful Use set

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Tropismo de VIH-1:Presencia o identidad:Punto temporal:Sangre:Narrativo:
es-MX Spanish (Mexico) Tropismo del VIH 1:Presencia o identidad:Punto temporal:Sangre:Narrativo:
fr-CA French (Canada) VIH 1 tropisme:Présence ou identité:Temps ponctuel:Sang:Narratif:
fr-FR French (France) VIH-1 tropisme:Identification:Ponctuel:Sang:Résultat textuel:
fr-BE French (Belgium) HIV 1 tropisme:Présence ou identité:Temps ponctuel:Sang:Narratif:
Synonyms: HIV HIV 1 HIV 1. Tropisme
it-IT Italian (Italy) HIV 1, tropismo:Prid:Pt:Sangue:Nar:
Synonyms: Microbiologia Presenza o Identità Punto nel tempo (episodio) Sangue Tropismo dell''HIV 1
nl-NL Dutch (Netherlands) HIV 1 tropisme:identificator:moment:bloed:tekstueel:
pl-PL Polish (Poland) HIV 1 tropizm:wykrycie lub identyfikacja:punkt w czasie:krew:opisowy:
Synonyms: Ludzki wirus niedoboru odporności typu 1 Tropizm ludzkiego wirusa niedoboru odporności typu 1
pt-BR Portuguese (Brazil) HIV 1 tropismo:Ident:Pt:SgTotal:Nar:
Synonyms: ; HIV1 tropism; CCR5; Trofile; Tropotype; CXCR4; R5; X4; CXCR4 (X4); HTLV III; HTLV 3; HIV type 1; HIV type I; AIDS; Human immunodeficiency virus; Identity or presence; Point in time; Random; Blood; WB; Whole blood; Narrative; Report; Microbiology
ru-RU Russian (Russian Federation) HIV 1 тропизм:ПрИд:ТчкВрм:Кр:Опис:
Synonyms: ВИЧ ВИЧ 1 Кровь Описательный Присутствие или Идентификация Точка во времени;Момент
tr-TR Turkish (Turkey) HIV 1 tropism:MevcKimlik:Zmlı:Kan:Öykü:
uk-UA Ukrainian (Ukraine) ВІЛ 1 Тропізм:Наявність або Ідентифікація:МоментЧасу:Кров:Описово:
Synonyms: AIDS; Blood; CCR5; CXCR4; CXCR4 (X4); HIV type 1; HIV type I; HIV1; HIV1 tropism; Human immunodeficiency virus; i; ID; Identity or presence; Infectious Disease; InfectiousDisease; Microbiology; Narrative; Point in time; R5; Random; Report; Trofile; Tropotype; WB; Whole blood; X4
zh-CN Chinese (China) HIV 1 型 嗜性:存在与否或特征标识:时间点:全血:叙述型:
Synonyms: Ⅰ AIDS;AIDS 病毒;人类免疫缺陷病毒;人类免疫缺陷病毒（Human immunodeficiency virus，HIV）;爱滋病;艾滋病;艾滋病病毒;获得性免疫缺陷综合征;获得性免疫缺陷综合征（Acquired Immure Deficiency Syndrome，AIDS，艾滋病） HIV 1 型（人类免疫缺陷病毒 1 型、人类免疫缺陷病毒 I 型、人免疫缺陷病毒 1 型、人免疫缺陷病毒 I 型、HIV I、HIV I 型、艾滋病病毒 I 型）嗜性（向性、趋性、趋向性）;HIV 1 亲嗜性;HIV 1 向性;HIV 1 细胞嗜性;HIV 1 趋向性;HIV 1 趋性;HIV1 嗜性;HTLV 3 嗜性;HTLV III 嗜性;人类免疫缺陷病毒 1 型 嗜性;人类免疫缺陷病毒 I 型 嗜性 HIV1;HTLV 3;HTLV III;人类免疫缺陷病毒 1 型;人类免疫缺陷病毒 I 型;HIV 1 型（人类免疫缺陷病毒 1 型、人类免疫缺陷病毒 I 型、人免疫缺陷病毒 1 型、人免疫缺陷病毒 I 型、HIV I、HIV I 型、艾滋病病毒 I 型） I 叙述;叙述性文字;报告;报告型;文字叙述;文本叙述型;文本描述;文本描述型 存在;存在与否;特征标识;身份;身份标识 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 时刻;随机;随意;瞬间 血;血液

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=53923-9