54003-9

Human upstream binding factor Ab [Presence] in Serum by Immunofluorescence

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Term Description

This entity has two names: "nucleolar organizing region (NOR) 90" versus "human upstream binding factor (hUBF)". Both names are right, and the literature looking for the antibody in autoimmune patients almost uniformly includes both names and the historical context. NOR90 stuck because it was called that by the author of the original finding in autoimmune patients (Rodriguez-Sanchez, et al, 1987), but a few years later (1994), the antigen was found to be identical to already characterized hUBF. So we are stuck with the 2 names. hUBF is more technically specific, and at least one recent review calls it "anti-hUBF, formerly anti-NOR 90" (Journal of Dermatology 2010; 37: 42-53). So we will use that as its primary name.

Part Description

LP71704-8 Human upstream binding factor
Human upstream binding factor (hUBF) is a nucleolar protein that plays a key role in rRNA production. The protein regulates rDNA transcription and also promotes rRNA synthesis. DNA binding to hUBF has the potential to alter chromatin by inducing chromatin remodeling. PMID: 25965800 Autoantibodies to hUBF (anti-hUBF) are associated with various connective tissue diseases, including systemic sclerosis, Raynaud's disease, rheumatoid arthritis and systemic lupus erythematosus. Anti-hUBF antibodies have also been associated with some malignancies. Anti-hUBF and anti-nucleolus-organizing region (NOR) 90 antibodies were originally described as distinct entities but later were recognized as being the same. PMID: 20175839 Source: Regenstrief LOINC, PMID: 20175839

LOINC Names Get Info

Fully-Specified Name: Human upstream binding factor Ab:PrThr:Pt:Ser:Ord:IF
Long Common Name: Human upstream binding factor Ab [Presence] in Serum by Immunofluorescence
Short Name: hUBF Ab Ser Ql IF
Display Name: Human upstream binding factor Ab IF Ql (S)
Consumer Name Alpha Get Info: Human upstream binding factor antibody, Blood

Part Model Get Info

Component
Human upstream binding factor Ab
LP71696-6
- Analyte
  Human upstream binding factor Ab
  LP71696-6
  - Component Numerator
    Human upstream binding factor Ab
    LP71696-6
    - Component Numerator Core
      Human upstream binding factor
      LP71704-8
    - Component Numerator Core Suffix
      Ab
      LP20667-9
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Ser
LP7567-3
- System Core
  Ser
  LP7567-3
- Super System
  NULL
Scale
Ord
LP7751-3
Method
IF
LP6323-2

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.26
Last Updated: Version 2.56 (MIN)
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both

Member of these Groups Get Info

LOINC Group	Group Name
LG21896-2	Human upstream binding factor Ab\|PrThr\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Lidský faktor UBF Ab:Přítomnost nebo práh:Časový bod:Sérum:Ordinální:Imunofluoresecence (IF)
de-AT	German (Austria)	Synonyms: NOR-90 AK ql.
de-DE	German (Germany)	Human upstream binding factor Ak:Nachweis oder Schwellenwert:Zeitpunkt:Serum:Ordinal:Immunfluoreszenztest Synonyms: NOR-90
el-GR	Greek (Greece)	Ανθρώπινος παράγοντας δέσμευσης ανάντη Αντίσωμα:PrThr:Pt:Ορός:Ord:Ανοσοφθορισμός Synonyms: Ord PrThr Pt SERO Ανθρώπινος παράγοντας δέσμευσης ανάντη Ανοσοφθορισμός Αντίσωμα Ορός
es-ES	Spanish (Spain)	factor de unión upstream humano Anticuerpos:PrThr:Punto temporal:Suero:Ord:Inmunofluorescencia (IF)
es-MX	Spanish (Mexico)	Factor de unión aguas arriba Ab humano:Presencia o umbral:Punto temporal:Suero:Ordinal:Inmunofluorescencia (IF)
et-EE	Estonian (Estonia)	NOR-90 antikehad:PrThr:Pt:S:Ord:IF Synonyms: Järgarvuline Juhuslik Seerum
fr-CA	French (Canada)	NOR-90, Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Immunofluorescence
fr-FR	French (France)	NOR-90 Ac:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Immunofluorescence
fr-BE	French (Belgium)	Human upstream binding factor Ac:PrThr:Temps ponctuel:Sérum:Ordinal:Immunofluorescence Synonyms: Anticorps
it-IT	Italian (Italy)	Fattore umano a monte legante Ab:PrThr:Pt:Siero:Ord:IF Synonyms: anticorpo hUBF Immunofluorescenza (IF) Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL	Dutch (Netherlands)	Humaan upstream binding factor As:aanwezigheid:moment:serum:ordinaal:immunofluorescentie Synonyms: antistof; antilichaam IF
pt-BR	Portuguese (Brazil)	NOR-90 Ac:ACnc:Pt:Soro:Ord:Imunofluorescência Synonyms: Nucleolus organizer regions; Arbitrary concentration; Point in time; Random; Serum; SR; Ql; Ordinal; QL; Qualitative; Qual; Screen; ACIF; FA; Fluorescent antibody; Immune fluorescence; Fluoresent; Immunoflour; Immunofluor; Immunofluorescence; IFA; Time Resolved Fluorescence; Anticomplement Immunofluorescence; TRF; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; Serology
ru-RU	Russian (Russian Federation)	Человеческий upstream binding factor Ат:PrThr:ТчкВрм:Сыв:Пор:ИФ Synonyms: Антитело Иммунофлюоресценция (ИФ) Порядковый Сыворотка Точка во времени;Момент
tr-TR	Turkish (Turkey)	Human upstream bağlayıcı factor Ab:MevcEşik:Zmlı:Ser:Srl:IF Synonyms: Ak İmmünflorerans Mevcut
zh-CN	Chinese (China)	人上游结合因子抗体:存在情况或阈值:时间点:血清:序数型:免疫荧光法 Synonyms: Ab;自身抗体 IFA法;IF法;抗补体免疫荧光法;时间分辨荧光法;荧光原位杂交技术;荧光原位杂交法;荧光抗体人上遊結合因子;人类上游结合因子;hUBF;Human upstream binding factor 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型因素存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）时刻;随机;随意;瞬间系数结合性结合性的血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.