Version 2.80

Term Description

This entity has two names: "nucleolar organizing region (NOR) 90" versus "human upstream binding factor (hUBF)". Both names are right, and the literature looking for the antibody in autoimmune patients almost uniformly includes both names and the historical context. NOR90 stuck because it was called that by the author of the original finding in autoimmune patients (Rodriguez-Sanchez, et al, 1987), but a few years later (1994), the antigen was found to be identical to already characterized hUBF. So we are stuck with the 2 names. hUBF is more technically specific, and at least one recent review calls it "anti-hUBF, formerly anti-NOR 90" (Journal of Dermatology 2010; 37: 42-53). So we will use that as its primary name.

Part Description

LP71704-8   Human upstream binding factor
Human upstream binding factor (hUBF) is a nucleolar protein that plays a key role in rRNA production. The protein regulates rDNA transcription and also promotes rRNA synthesis. DNA binding to hUBF has the potential to alter chromatin by inducing chromatin remodeling. PMID: 25965800 Autoantibodies to hUBF (anti-hUBF) are associated with various connective tissue diseases, including systemic sclerosis, Raynaud's disease, rheumatoid arthritis and systemic lupus erythematosus. Anti-hUBF antibodies have also been associated with some malignancies. Anti-hUBF and anti-nucleolus-organizing region (NOR) 90 antibodies were originally described as distinct entities but later were recognized as being the same. PMID: 20175839 Source: Regenstrief LOINC , PMID: 20175839

Fully-Specified Name

Component
Human upstream binding factor Ab
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method
IF

Additional Names

Long Common Name
Human upstream binding factor Ab [Presence] in Serum by Immunofluorescence
Short Name
hUBF Ab Ser Ql IF
Display Name
Human upstream binding factor Ab IF Ql (S)
Consumer Name Alpha Get Info
Human upstream binding factor antibody, Blood

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.26
Last Updated
Version 2.56 (MIN)
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG21896-2 Human upstream binding factor Ab|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: NOR-90 AK ql.
de-DE German (Germany) Human upstream binding factor Ak:Nachweis oder Schwellenwert:Zeitpunkt:Serum:Ordinal:Immunfluoreszenztest
Synonyms: NOR-90
el-GR Greek (Greece) Ανθρώπινος παράγοντας δέσμευσης ανάντη Αντίσωμα:PrThr:Pt:Ορός:Ord:Ανοσοφθορισμός
Synonyms: PrThr Ανθρώπινος παράγοντας δέσμευσης ανάντη
es-ES Spanish (Spain) factor de unión upstream humano Anticuerpos:PrThr:Punto temporal:Suero:Ord:Inmunofluorescencia (IF)
es-MX Spanish (Mexico) Factor de unión aguas arriba Ab humano:Presencia o umbral:Punto temporal:Suero:Ordinal:Inmunofluorescencia (IF)
et-EE Estonian (Estonia) NOR-90 antikehad:PrThr:Pt:S:Ord:IF
Synonyms: Järgarvuline Juhuslik Seerum
fr-CA French (Canada) NOR-90, Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Immunofluorescence
fr-FR French (France) NOR-90 anticorps:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Immunofluorescence
fr-BE French (Belgium) Human upstream binding factor Ac:PrThr:Temps ponctuel:Sérum:Ordinal:Immunofluorescence
Synonyms: Anticorps
it-IT Italian (Italy) Fattore umano a monte legante Ab:PrThr:Pt:Siero:Ord:IF
Synonyms: anticorpo hUBF Immunofluorescenza (IF) Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) Humaan upstream binding factor As:aanwezigheid:moment:serum:ordinaal:immunofluorescentie
Synonyms: antistof; antilichaam IF
pt-BR Portuguese (Brazil) NOR-90 Ac:ACnc:Pt:Soro:Ord:Imunofluorescência
Synonyms: Nucleolus organizer regions; Arbitrary concentration; Point in time; Random; Serum; SR; Ql; Ordinal; QL; Qualitative; Qual; Screen; ACIF; FA; Fluorescent antibody; Immune fluorescence; Fluoresent; Immunoflour; Immunofluor; Immunofluorescence; IFA; Time Resolved Fluorescence; Anticomplement Immunofluorescence; TRF; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; Serology
ru-RU Russian (Russian Federation) Человеческий upstream binding factor Ат:PrThr:ТчкВрм:Сыв:Пор:ИФ
Synonyms: Антитело Иммунофлюоресценция (ИФ) Порядковый Сыворотка Точка во времени;Момент
tr-TR Turkish (Turkey) Human upstream bağlayıcı factor Ab:MevcEşik:Zmlı:Ser:Srl:IF
Synonyms: İmmünflorerans Mevcut
zh-CN Chinese (China) 人上游结合因子 抗体:存在情况或阈值:时间点:血清:序数型:免疫荧光法
Synonyms: Ab;自身抗体 IFA法;IF法;抗补体免疫荧光法;时间分辨荧光法;荧光原位杂交技术;荧光原位杂交法;荧光抗体 人上遊結合因子;人类上游结合因子;hUBF;Human upstream binding factor 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 因素 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 系数 结合性 结合性的 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

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