54023-7
U1 small nuclear ribonucleoprotein C Ab [Presence] in Serum
Active
Part Description
LP71712-1 U1 small nuclear ribonucleoprotein C
U1 small nuclear ribonucleoprotein particle (U1 snRNP) is an RNA-protein complex that is composed of ten proteins: U1-70kD, U1A, U1C and seven Smith antigen (Sm) proteins. The U1 snRNP complex is responsible for pre-mRNA processing. Autoantibodies to different components of the U1 snRNP complex are associated with autoimmune conditions including systemic lupus erythematosus (SLE) and mixed connective tissue disorders (MCTD), which includes systemic sclerosis. The pattern of autoantibodies present in an individual patient may help distinguish between different connective tissue disorders. For example, patients with anti-U1A and anti-U1C IgM antibodies are more likely to have SLE than MCTD. PMID: 24158973 In addition, there is some evidence that specific antibody patterns are associated with specific symptoms. For example, among patients with SLE, the combination of anti-U1-70kD, anti-U1A and anti-U1C correlates with Raynaud's phenomenon, while anti-U1-70kD and anti-U1A (without anti-U1C) correlate with leukopenia. Another study found an association between the number of specific positive antibodies within the anti-U1 snRNP (rather than the presence of particular markers) and certain clinical features. For example, patients with three or more positive autoantibodies were more likely to have features of systemic sclerosis and less likely to have renal disease compared to patients with fewer types of antibodies. PMID: 20015915
Source: Regenstrief LOINC, PMID: 24158973
Fully-Specified Name
- Component
- U1 small nuclear ribonucleoprotein C Ab
- Property
- PrThr
- Time
- Pt
- System
- Ser
- Scale
- Ord
- Method
Additional Names
- Short Name
- U1 snRNP-C Ab Ser Ql
- Display Name
- U1 small nuclear ribonucleoprotein C Ab Ql (S)
- Consumer Name Alpha Get Info
- U1 Small Nuclear Ribonucleoprotein C antibody, Blood
Example Answer List: LL360-9
Source: Regenstrief InstituteAnswer | Code | Score | Answer ID |
---|---|---|---|
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 |
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.26
- Last Updated
- Version 2.56
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
Member of these Groups Get Info
LOINC Group | Group Name |
---|---|
LG21917-6 | U1 small nuclear ribonucleoprotein C Ab| |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
de-AT | German (Austria) | Synonyms: U1-snRNP-C-AK ql. |
de-DE | German (Germany) | U1 kleine nukleäre Ribonukleoprotein-C Ak: |
es-ES | Spanish (Spain) | U1 ribonucleoproteína nuclear pequeña C Anticuerpos: |
es-MX | Spanish (Mexico) | U1 ribonucleoproteína nuclear sub C Ab: |
fr-CA | French (Canada) | Petite particule nucléaire ribonucléoprotéique U1 C, Ac: |
fr-FR | French (France) | U1 RNP C anticorps: |
fr-BE | French (Belgium) | Petite particule nucléaire ribonucléoprotéique U1 C Ac: Synonyms: Anticorps |
it-IT | Italian (Italy) | U1, piccola ribonucleoproteina nucleare C Ab: Synonyms: anticorpo Piccola ribonucleoproteina nucleare U1 Piccola ribonucleoproteina nucleare U1 C Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant |
nl-NL | Dutch (Netherlands) | u1 small nucleair ribonucleoproteïne C As: Synonyms: antistof; |
pt-BR | Portuguese (Brazil) | U1 Ribonucleoproteína núcleo pequeno C Ac: Synonyms: ; |
ru-RU | Russian (Russian Federation) | U1 малый ядерный рибонуклеопротеин C Ат: Synonyms: Антитело Порядковый Сыворотка Точка во времени; |
tr-TR | Turkish (Turkey) | U1 kçk nükleer ribonükleoprotein C Ab: Synonyms: Ak Çekirdek Mevcut |
zh-CN | Chinese (China) | U1 小细胞核核糖核蛋白 C 抗体: Synonyms: Ab; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=54023-7
Third Party Copyright
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LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright