5444-5

Deprecated CD19 cells/100 cells in Blood

Deprecated

Status Information

Status: DEPRECATED
Reason: Duplicate

Map-To	Long Common Name	Mapping Guidance
8117-4	CD19 cells/cells in Blood

Part Descriptions

LP17759-9 CD19
CD19 (Cluster of Differentiation 19), is a human protein encoded by the CD19 gene.
Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells.
It primarily acts as a B cell co-receptor in conjunction with CD21 and CD81.
Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated which leads to binding by Src-family kinases and recruitment of PI-3 kinase. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, CD18

LP17759-9 CD19
The CD19+ B cells are 95 kilo Dalton transmembrane glycoproteins and are comprised of a single transmembrane domain, a cytoplasmic C-terminus, and an extracellular N-terminus. It is a biomarker for normal and neoplastic B cells and for dendritic cells. CD19+ B cells regulate signaling thresholds by modifying B cell receptor dependent and independent signaling, functioning as a dominant piece of a multimolecular complex that resides on the mature B cell surface. The concentration of CD19 on the surface of B cells is tightly controlled throughout the cell's development, making it a very valuable biomarker for B cells. Mature B cells have three times the number of CD19 antigens than immature B cells, and when B cells differentiate into plasma cells, the expression of CD19 is lost. Patients who lack sufficient CD19 antigens have a lower response to transmembrane signals and weak T cell dependent antibody responses. CD19 is highly conserved and expressed in most B cell malignancies including acute lymphocytic leukemia, B cell lymphoma, and B cell leukemia. Efforts are in play to utilize CD19 antibodies for the treatment of lymphoma, leukemia, and autoimmune disorders. PMID: 23210908 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: CD19:ACnc:Pt:WBC:Qn:
Long Common Name: Deprecated CD19 cells/100 cells in Blood
Short Name: Deprecated CD19 WBC-aCnc
Display Name: CD19 Qn (WBC)
Consumer Name Alpha Get Info: CD19, White blood cells

Part Model Get Info

Component
CD19
LP17759-9
- Analyte
  CD19
  LP17759-9
  - Component Numerator
    CD19
    LP17759-9
    - Component Numerator Core
      CD19
      LP17759-9
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
ACnc
LP6773-8
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
WBC
LP7720-8
- System Core
  WBC
  LP7720-8
- Super System
  NULL
Scale
Qn
LP7753-9
Method
NULL

Basic Attributes

Class: CELLMARK
Type: Laboratory
First Released: Version 1.0
Last Updated: Version 2.69 (MIN)

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	CD19:Arbitrární koncentrace:Časový bod:Leukocyty:Kvantitativní:
el-GR	Greek (Greece)	CD19:ACnc:Pt:Αριθμός λευκών αιμοσφαιρίων:Qn: Synonyms: ACnc CD19 CELLMARK Pt Qn Αριθμός λευκών αιμοσφαιρίων
es-AR	Spanish (Argentina)	CD19:concentración arbitraria:punto en el tiempo:leucocito:cuantitativo:
es-ES	Spanish (Spain)	Células CD19+:Concentración arbitraria:Punto temporal:Células sanguineas blancas:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	CD19:Concentración arbitraria:Punto temporal:células blancas de la sangre:Cuantitativo:
et-EE	Estonian (Estonia)	CD19:Acnc:Pt:WBC:Qn: Synonyms: Juhuslik Kvantitatiivne Leukotsüüdid
fr-CA	French (Canada)	CD19:Concentration arbitraire:Temps ponctuel:Leucocytes:Quantitatif:
fr-BE	French (Belgium)	CD19:Concentration arbitraire:Temps ponctuel:Leucocytes:Quantitatif: Synonyms: Cellules.CD19+
fr-FR	French (France)	CD19:Arbitraire/Volume:Ponctuel:Leucocytes:Numérique:
it-IT	Italian (Italy)	CD19:ACnc:Pt:WBC:Qn: Synonyms: Concentrazione Arbitraria Globuli bianchi Modelli di superficie cellulare Punto nel tempo (episodio)
nl-NL	Dutch (Netherlands)	CD19:eenheid/volume:moment:leukocyten:kwantitatief: Synonyms: witte bloedcellen
pl-PL	Polish (Poland)	CD19:stężenie w jednostkach umownych:punkt w czasie:leukocyty:ilościowy: Synonyms: CD19
pt-BR	Portuguese (Brazil)	CD19:ACnc:Pt:Leucoc:Qn: Synonyms: Leu-12; B-4; HD-37; B4; Leu12; Arbitrary concentration; Point in time; Random; Leukocytes; White blood cells; Leucocs; Quantitative; QNT; Quant; Quan; CELL MARKERS
ru-RU	Russian (Russian Federation)	CD19:ПроизвКонц:ТчкВрм:Лейкоциты:Колич: Synonyms: Количественный Произвольная концентрация Точка во времени;Момент
tr-TR	Turkish (Turkey)	CD19:SçKons:Zmlı:Lökosit:Kant: Synonyms: WBC
zh-CN	Chinese (China)	CD19:任意型浓度:时间点:白细胞:定量型: Synonyms: B4;B-4;HD-37;Leu12;Leu-12 WBC;WBCs;白血球;白血细胞任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度可用数量表示的;定量性;数值型;数量型;连续数值型标尺时刻;随机;随意;瞬间细胞标志物

Example Units

Unit	Source
[arb'U]/mL	Example UCUM Units

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.