Version 2.78

Part Description

LP93517-8   Human epididymis protein 4
Human epididymis protein 4 (known as HE4, or as WAP four-disulfide core domain protein 2) is a protein that in humans is encoded by the WFDC2 gene and belongs to the family of whey acidic four-disulfide core (WFDC) proteins. HE4 is overexpressed in both ovarian and endometrial cancers and is an important biomarker that complements CA 125 in discriminating between benign and malignant pelvic masses, monitoring response to treatment, and detecting recurrences of both ovarian and endometrial cancer. The risk of ovarian malignancy algorithm (ROMA) includes CA 125, HE4, and menopausal status to distinguish benign from malignant adnexal masses. HE4 may augment the sensitivity of CA 125 for detecting early-stage ovarian cancer. PMID: 23909069 Source: Regenstrief LOINC, PMID: 23909069

Reference Information

Type Source Reference
Fda 510K Regenstrief Help FDA_510k

Fully-Specified Name

Component
Human epididymis protein 4
Property
SCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Long Common Name
Human epididymis protein 4 [Moles/volume] in Serum or Plasma
Short Name
HE4 SerPl-sCnc
Display Name
Human epididymis protein 4 [Moles/Vol]
Consumer Name Alpha Get Info
Human epididymis protein 4, Blood

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.27
Last Updated
Version 2.73
Change Reason
System changed from serum to fit the updated procedures.
Order vs. Observation
Both
Common Test Rank Get Info
4718

Member of these Panels

LOINC Long Common Name
104551-7 Ovarian malignancy (ROMA) panel - Serum or Plasma

Member of these Groups Get Info

LOINC Group Group Name
LG51042-6 Human epididymis protein 4|Pt|Ser/Plas
LG22449-9 Human epididymis protein 4|SCnc|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: HE4
es-ES Spanish (Spain) Proteína 4 del epidídimo humano:Concentración de sustancia:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Proteína 4 del epidídimo humano:Concentración de sustancias:Punto temporal:Suero o Plasma:Cuantitativo:
et-EE Estonian (Estonia) Kasvajaantigeen HE4:SCnc:Pt:S/P:Qn:
Synonyms: Aine kontsentratsioon Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-FR French (France) Protéine HE4:Moles/Volume:Ponctuel:Sérum/Plasma:Numérique:
fr-BE French (Belgium) Protéine 4. épididyne humain:Concentration de substance:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-CA French (Canada) Protéine 4 épididyme humaine:Concentration de substance:Temps ponctuel:Sérum/Plasma:Quantitatif:
it-IT Italian (Italy) Epididimo umano, proteina 4:SCnc:Pt:Siero/Plasma:Qn:
Synonyms: Chimica Concentrazione di Sostanza Plasma Proteina 4 dell''epididimo umano Punto nel tempo (episodio) Siero Siero o Plasma
nl-NL Dutch (Netherlands) Humaan epididymis proteïne 4:mol/volume:moment:serum of plasma:kwantitatief:
pt-BR Portuguese (Brazil) Proteína humana epidídimo 4:#N/A:Pt:Soro:Qn:
Synonyms: ; Prot; PR; HE4; Substance concentration; Level; Point in time; Random; Serum; SR; Quantitative; QNT; Quant; Quan; Chemistry
ru-RU Russian (Russian Federation) Человеческий придаток яичка протеин 4:МолКонц:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Белок Белок 4 эпидидимиса человека Количественный Молярность;Молярная объёмная концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Human epididymis protein 4:SubKons:Zmlı:Ser/Plaz:Kant:
zh-CN Chinese (China) 人附睾蛋白 4:物质的量浓度:时间点:血清/血浆:定量型:
Synonyms: PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质 人类附睾蛋白 4;HE4;Human epididymal protein 4;人附睾上皮分泌蛋白 4;人附睾分泌蛋白 4 克分子浓度;克分子浓度(单位体积);摩尔浓度;摩尔浓度(单位体积);物质的量浓度(单位体积) 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 血清或血浆

Example Units

Unit Source
pmol/L Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=55180-4