LP93517-8
Human epididymis protein 4
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Descriptions
Human epididymus protein 4 (HE4) is a secretory protein. HE4 has a size of 20-25 kDa with a 13 KDa (approx.) protein core. Increased levels are found in ovarian cancer, provides increased sensitivity over CA 125 alone. Source: Regenstrief Institute
HE4 circulates in the bloodstream of patients with epithelial ovarian cancer. It is a secreted glycoprotein that is overexpressed by serous and endometrioid epithelial ovarian cancers Source: Regenstrief Help
Human epididymis protein 4 (known as HE4, or as WAP four-disulfide core domain protein 2) is a protein that in humans is encoded by the WFDC2 gene and belongs to the family of whey acidic four-disulfide core (WFDC) proteins. HE4 is overexpressed in both ovarian and endometrial cancers and is an important biomarker that complements CA 125 in discriminating between benign and malignant pelvic masses, monitoring response to treatment, and detecting recurrences of both ovarian and endometrial cancer. The risk of ovarian malignancy algorithm (ROMA) includes CA 125, HE4, and menopausal status to distinguish benign from malignant adnexal masses. HE4 may augment the sensitivity of CA 125 for detecting early-stage ovarian cancer. PMID: 23909069 Source: Regenstrief LOINC, PMID: 23909069
Basic Part Properties
- Part Display Name
- Human epididymis protein 4
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2009-03-06
- Construct for LOINC Short Name
- HE4
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 人附睾蛋白 4 Synonyms: 人类附睾蛋白 4; |
| et-EE | Estonian (Estonia) | Kasvajaantigeen HE4 |
| es-ES | Spanish (Spain) | Proteína 4 del epidídimo humano |
| it-IT | Italian (Italy) | Epididimo umano, proteina 4 Synonyms: Proteina 4 dell''epididimo umano |
| tr-TR | Turkish (Turkey) | Human epididymis protein 4 |
| ru-RU | Russian (Russian Federation) | Человеческий придаток яичка протеин 4 Synonyms: Белок 4 эпидидимиса человека |
| nl-NL | Dutch (Netherlands) | Humaan epididymis proteïne 4 |
| fr-BE | French (Belgium) | Protéine 4. épididyne humain |
| fr-CA | French (Canada) | Protéine 4 épididyme humaine |
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