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Part Descriptions

LP94538-3   VIM gene methylation
Vimentin gene methylation is stool based DNA test for the dection of colon cancer. Source: Regenstrief Institute

LP124510-1   gene methylation
DNA methylation is essential during embryonic development, and patterns of DNA methylation are generally transmitted to daughter cells with a high fidelity. In cancer, aberrant DNA methylation patterns are found in two distinct forms: hypermethylation and hypomethylation. Hypermethylation is one of the major epigenetic modifications that repress transcription via the promoter region of tumor suppressor genes. Hypermethylation typically occurs at CpG islands in the promoter region and is associated with gene inactivation. Hypomethylation, linked to chromosomal instability and loss of imprinting, arises earlier and occurs throughout the progression of cancer.

More specifically, methylated DNA can bind to methyl-CpG-binding domain proteins (MBDs), which recruit additional proteins such as histone deacetylases and other chromatin remodeling proteins that modify histones to form compact, inactive chromatin, termed silent chromatin. Loss of methyl-CpG-binding protein 2 (MeCP2) has been implicated in Rett syndrome; and methyl-CpG-binding domain protein 2 (MBD2) mediates the transcriptional silencing of hypermethylated genes in cancer. Research has suggested that long-term memory storage in humans may be regulated by DNA methylation. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

Reference Information

TypeSourceReference
WebcontentRegenstrief Institute Link to LabCorp - ColoSure

LOINC Names Get Info

Fully-Specified Name
VIM gene methylation:Arb:Pt:Stool:Ord:Molgen
Long Common Name
VIM gene methylation [Presence] in Stool by Molecular genetics method
Short Name
VIM gene methylation Stl Ql
Display Name
VIM gene methylation Molgen Ql (Stl)
Consumer Name Alpha Get Info
VIM gene methylation, Stool

Part Model Get Info

  • Component
    VIM gene methylation
    LP94538-3
    • Analyte
      VIM gene methylation
      LP94538-3
      • Component Numerator
        VIM gene methylation
        LP94538-3
        • Component Numerator Core
          VIM gene methylation
          LP94538-3
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Arb
    LP6781-1
  • Time
    Pt
    LP6960-1
  • System
    Stool
    LP7604-4
    • System Core
      Stool
      LP7604-4
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    Molgen
    LP6404-0

Example Answer List: LL360-9

Source: Regenstrief Institute
AnswerCodeScoreAnswer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)LA6577-6

Basic Attributes

Class
MOLPATH
Type
Laboratory
First Released
Version 2.27
Last Updated
Version 2.27 (MIN)
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Gen VIM methylace:Arbitrární:Časový bod:Stolice:Ordinální:Molekulární genetika
el-GRGreek (Greece)Μεθυλίωση γονιδίου VIM:Arb:Pt:Κόπρανα:Ord:Μοριακή γενετική
Synonyms: Arb MOLPATH Ord Pt Γονίδιο Κόπρανα Μεθυλίωση γονιδίου VIM Μοριακή γενετική
es-ESSpanish (Spain)Gen de metilación VIM:Arbitrario:Punto temporal:Heces:Ord:Genética molecular
es-MXSpanish (Mexico)Metilación del gen VIM:Arbitrario:Punto temporal:Heces:Ordinal:Genética molecular
fr-FRFrench (France)VIM gène méthylation:Arbitraire:Ponctuel:Selle:Qualitatif:Biologie moléculaire
it-ITItalian (Italy)VIM, metilazione gene:Arb:Pt:Feci:Ord:Molgen
Synonyms: Arbitrario Genetica molecolare Metilazione di gene VIM Patologia molecolare Punto nel tempo (episodio)
nl-NLDutch (Netherlands)VIM-gen methylatie:aanwezigheid:moment:feces:ordinaal:moleculair genetisch onderzoek
Synonyms: molgen ontlasting; feces VIM gen methylatie
pl-PLPolish (Poland)VIM gen metylacja:jednostka umowna:punkt w czasie:kał:uporządkowany:genetyka molekularna
Synonyms: diagnostyka molekularna Metylacja genu VIM
pt-BRPortuguese (Brazil)VIM gene metilação:#N/A:Pt:Fezes:Ord:Genética molecular
Synonyms: Vimentin; Arbitrary; Point in time; Random; Stl; Feces; Faeces; Bowel movement; Fecal; Faecal; Ql; Ordinal; QL; Qualitative; Qual; Screen; PCR; Molecular genetics; Molecular pathology; ColoSure
ru-RURussian (Russian Federation)VIM ген метилирование:Произв:ТчкВрм:Фекалии:Пор:МолГен
Synonyms: Порядковый Произвольный Точка во времени;Момент
tr-TRTurkish (Turkey)VIM geni metilasayonu:Sç:Zmlı:Dışkı:Srl:Molgen
Synonyms: Gaita; feçes
zh-CNChinese (China)VIM 基因甲基化:任意型:时间点:大便:序数型:分子遗传学类实验室方法
Synonyms: vimentin;波形蛋白;波形纤维蛋白;VIM;RP11-124N14.1 任意;任意的;人工型 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 便;大肠运动;排便;粪便;肠运动 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 时刻;随机;随意;瞬间 遗传基因;遗传因子;吉恩;生物基因

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=55345-3