55345-3
VIM gene methylation [Presence] in Stool by Molecular genetics method
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Part Descriptions
LP94538-3 VIM gene methylation
Vimentin gene methylation is stool based DNA test for the dection of colon cancer.
Source: Regenstrief Institute
LP124510-1 gene methylation
DNA methylation is essential during embryonic development, and patterns of DNA methylation are generally transmitted to daughter cells with a high fidelity. In cancer, aberrant DNA methylation patterns are found in two distinct forms: hypermethylation and hypomethylation. Hypermethylation is one of the major epigenetic modifications that repress transcription via the promoter region of tumor suppressor genes. Hypermethylation typically occurs at CpG islands in the promoter region and is associated with gene inactivation. Hypomethylation, linked to chromosomal instability and loss of imprinting, arises earlier and occurs throughout the progression of cancer.
More specifically, methylated DNA can bind to methyl-CpG-binding domain proteins (MBDs), which recruit additional proteins such as histone deacetylases and other chromatin remodeling proteins that modify histones to form compact, inactive chromatin, termed silent chromatin. Loss of methyl-CpG-binding protein 2 (MeCP2) has been implicated in Rett syndrome; and methyl-CpG-binding domain protein 2 (MBD2) mediates the transcriptional silencing of hypermethylated genes in cancer. Research has suggested that long-term memory storage in humans may be regulated by DNA methylation.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia, Wikipedia
Reference Information
Type | Source | Reference |
---|---|---|
Webcontent | Regenstrief Institute | Link to LabCorp - ColoSure |
Fully-Specified Name
- Component
- VIM gene methylation
- Property
- Arb
- Time
- Pt
- System
- Stool
- Scale
- Ord
- Method
- Molgen
Additional Names
- Long Common Name
- VIM gene methylation [Presence] in Stool by Molecular genetics method
- Short Name
- VIM gene methylation Stl Ql
- Display Name
- VIM gene methylation Molgen Ql (Stl)
- Consumer Name Alpha Get Info
- VIM gene methylation, Stool
Example Answer List: LL360-9
Source: Regenstrief InstituteAnswer | Code | Score | Answer ID |
---|---|---|---|
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 |
Basic Attributes
- Class
- MOLPATH
- Type
- Laboratory
- First Released
- Version 2.27
- Last Updated
- Version 2.27
- Order vs. Observation
- Both
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-ES | Spanish (Spain) | Gen de metilación VIM: |
es-MX | Spanish (Mexico) | Metilación del gen VIM: |
fr-FR | French (France) | VIM gène méthylation: |
it-IT | Italian (Italy) | VIM, metilazione gene: Synonyms: Arbitrario Genetica molecolare Metilazione di gene VIM Patologia molecolare Punto nel tempo (episodio) |
nl-NL | Dutch (Netherlands) | VIM-gen methylatie: Synonyms: molgen ontlasting; |
pt-BR | Portuguese (Brazil) | VIM gene metilação: Synonyms: Vimentin; |
ru-RU | Russian (Russian Federation) | VIM ген метилирование: Synonyms: Порядковый Произвольный Точка во времени; |
tr-TR | Turkish (Turkey) | VIM geni metilasayonu: Synonyms: Gaita; |
zh-CN | Chinese (China) | VIM 基因甲基化: Synonyms: vimentin; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=55345-3
Third Party Copyright
This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.
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LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://