LOINC
Version 2.67

55345-3VIM gene methylation [Presence] in Stool by Molecular genetics methodActive

Part Descriptions

LP94538-3   VIM gene methylation
Vimentin gene methylation is stool based DNA test for the dection of colon cancer. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Regenstrief Institute, Wikipedia

LP124510-1   gene methylation
DNA methylation is essential during embryonic development, and patterns of DNA methylation are generally transmitted to daughter cells with a high fidelity. In cancer, aberrant DNA methylation patterns are found in two distinct forms: hypermethylation and hypomethylation. Hypermethylation is one of the major epigenetic modifications that repress transcription via the promoter region of tumor suppressor genes. Hypermethylation typically occurs at CpG islands in the promoter region and is associated with gene inactivation. Hypomethylation, linked to chromosomal instability and loss of imprinting, arises earlier and occurs throughout the progression of cancer.

More specifically, methylated DNA can bind to methyl-CpG-binding domain proteins (MBDs), which recruit additional proteins such as histone deacetylases and other chromatin remodeling proteins that modify histones to form compact, inactive chromatin, termed silent chromatin. Loss of methyl-CpG-binding protein 2 (MeCP2) has been implicated in Rett syndrome; and methyl-CpG-binding domain protein 2 (MBD2) mediates the transcriptional silencing of hypermethylated genes in cancer. Research has suggested that long-term memory storage in humans may be regulated by DNA methylation. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

Fully-Specified Name

Component
VIM gene methylation
Property
Arb
Time
Pt
System
Stool
Scale
Ord
Method
Molgen

Additional Names

Short Name
VIM gene methylation Stl Ql
Display Name
VIM gene methylation Molgen Ql (Stl)

Basic Attributes

Class
MOLPATH
Type
Laboratory
First Released
Version 2.27
Last Updated
Version 2.27
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Reference Information

Type Source Reference
Webcontent Regenstrief Institute Link to LabCorp - ColoSure

Language Variants Get Info

zh-CNChinese (CHINA)
VIM 基因甲基化:任意型:时间点:大便:序数型:分子遗传学类实验室方法
nl-NLDutch (NETHERLANDS)
VIM-gen methylatie:aanwezigheid:moment:feces:ordinaal:moleculair genetisch onderzoek
fr-FRFrench (FRANCE)
VIM gène méthylation:Arbitraire:Ponctuel:Selles:Qualitatif:Biologie moléculaire
it-ITItalian (ITALY)
VIM, metilazione gene:Arb:Pt:Feci:Ord:Molgen
pt-BRPortuguese (BRAZIL)
VIM gene metilação:#N/A:Pt:Fezes:Ord:Genética molecular
ru-RURussian (RUSSIAN FEDERATION)
VIM ген метилирование:Произв:ТчкВрм:Фекалии:Пор:МолГен
es-ESSpanish (SPAIN)
Gen de metilación VIM:Arbitrario:Punto temporal:Heces:Ord:Genética molecular
tr-TRTurkish (TURKEY)
VIM geni metilasayonu:Sç:Zmlı:Dışkı:Srl:Molgen

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=55345-3