Version 2.77

Part Description

LP16758-2   SCL-70 extractable nuclear
Topoisomerase I (also known as Scl-70) is a nuclear enzyme that plays a role in releasing tension that is introduced in double-stranded DNA during DNA replication by transiently cleaving and rejoining one strand of the DNA duplex. Anti-Scl-70 autoantibodies are a marker of systemic sclerosis as well as other autoimmune diseases, including systemic lupus erythematosus (SLE). In patients with systemic sclerosis, anti-SCL-70 may be associated with more severe disease, and in patients with SLE, anti-SCL-70 suggests an increased risk of pulmonary hypertension and renal involvement. In general, anti-SCL-70 antibody status may help with diagnosis, treatment planning and prognosis in patients with connective tissue disease. PMID: 11229469 Source: Regenstrief LOINC, PMID: 11229469

Fully-Specified Name

Component
SCL-70 extractable nuclear Ab
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method
IB

Additional Names

Short Name
ENA Scl70 Ab Ser Ql IB
Display Name
SCL-70 extractable nuclear Ab IB Ql (S)
Consumer Name Alpha Get Info
SCL-70 extractable nuclear antibody, Blood

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.29
Last Updated
Version 2.58
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG5141-9 SCL-70 extractable nuclear Ab|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: Scl-70 AK ql. IB
de-DE German (Germany) SCL-70 extrahierbarer nukleärer Ak:Nachweis oder Schwellenwert:Zeitpunkt:Serum:Ordinal:Immunoblot
Synonyms: Scl-70
es-ES Spanish (Spain) Antígeno nuclear extraíble SCL-70 Anticuerpos:PrThr:Punto temporal:Suero:Ord:Inmunoblot (IB)
es-MX Spanish (Mexico) Ab nuclear extraíble SCL-70:Presencia o umbral:Punto temporal:Suero:Ordinal:Inmunotransferencia
fr-CA French (Canada) SCL-70 nucléaire soluble , Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Immunoblot
fr-FR French (France) SCL-70 anticorps:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Immunoblot
fr-BE French (Belgium) SCL-70 nucléaire soluble Ac:PrThr:Temps ponctuel:Sérum:Ordinal:Immunoblot
Synonyms: Anticorps
it-IT Italian (Italy) Nucleare estraibile SCL-70 Ab:PrThr:Pt:Siero:Ord:IB
Synonyms: anticorpo ENA Immunoblot (IB) Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) SCL-70 extraheerbare nucleaire As:aanwezigheid:moment:serum:ordinaal:immunoblotting
Synonyms: antistof; antilichaam IB
pl-PL Polish (Poland) SCL-70 rozpuszczalny jądrowy Ab:granica wykrywalności:punkt w czasie:surowica:półilościowy:immunoblotting
Synonyms: Przeciwciała do rozpuszczalnego antygenu jądrowego Przeciwciała przeciwjądrowe SCL-70 rozpuszczalny jądrowy
pt-BR Portuguese (Brazil) SCL-70 Ac:#N/A:Pt:Soro:Ord:Imunoblot
Synonyms: ; ENA Scl70; Scleroderma Ac; ANA; ANF; NA; Antinuclear antibody; Nuc; Arbitrary concentration; Point in time; Random; Serum; SR; Ql; Ordinal; QL; Qualitative; Qual; Screen; Western blot; WB; Immune blot; Immunobl; Blt; WBLOT; West blt; West blot; RIBA; Immunoblot; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; Serology
ru-RU Russian (Russian Federation) SCL-70 экстрагируемый ядерный Ат:PrThr:ТчкВрм:Сыв:Пор:ИБ
Synonyms: Антитело Иммуноблот (ИБ) Порядковый Сыворотка Точка во времени;Момент
tr-TR Turkish (Turkey) SCL-70 özütlenebilir nükleer Ab:MevcEşik:Zmlı:Ser:Srl:IB
Synonyms: Ak Çekirdek Mevcut
zh-CN Chinese (China) SCL-70 可提取性核 抗体:存在情况或阈值:时间点:血清:序数型:免疫印迹法
Synonyms: Ab;自身抗体 ANA ENA Ab ENA SCL-70 Ab ENA SCL-70 抗体 ENA SCL-70;SCL-70 可提取性核 Ag;SCL-70 可提取性核抗原;可提取性核抗原 SCL-70;皮硬化症 Ab;皮硬化症抗体;硬皮病 Ab;硬皮病抗体;硬皮症 Ab;硬皮症抗体 ENA 抗体 ENA;可提取性核 Ag;可提取性核抗原;可提取性核抗原（Extractable Nuclear Antigen，ENA）;可提取性细胞核;可提取性细胞核 Ag;可提取性细胞核抗原;盐水可提取性核 Ag;盐水可提取性核抗原;盐水可提取性细胞核 Ag;盐水可提取性细胞核抗原 NA SCL-70 可提取性核 Ab SCL-70 可提取性核 Ag Ab SCL-70 可提取性核抗原抗体 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫印迹;西部印迹法;Immunoblot;immunoblotting;IB 可提取性核 Ab 可提取性核 Ag 之 Ab 可提取性核抗原 SCL-70 Ab 可提取性核抗原 SCL-70 抗体 可提取性核抗原之抗体 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 抗 ENA 抗可提取性核 Ag 抗可提取性核抗原 抗核 Ab 抗核抗体 抗核抗体（Antinuclear antibody，ANA） 时刻;随机;随意;瞬间 核;胞核 皮硬化症 硬皮病 硬皮病（Scleroderma，SCL） 硬皮症 细胞核 Ab 胞核 Ab 胞核抗体 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=56693-5