56734-7

Centromere protein B Ab [Presence] in Serum by Immunoblot

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Part Description

LP71684-2 Centromere protein B Ab
Major centromere autoantigen B, also known as centromere protein B or CENP-B, is encoded by the CENPB gene located on chromosome 20p13. CENP-B interacts with chromosomal centromeric heterochromatin and binds to a specific subset of alphoid satellite DNA, called the CENP-B box. [UniProt: P07199] CENP-B plays a direct role in stablizing CENP-C, which is a kinetochore assembly nucleator, and recruiting CENP-A, which marks and maintains centromere position. Chromosomes that have centromeres without bound CENP-B, including the human Y chromosome, are more likely to missegregate at much higher rates than chromosomes with CENP-B containing centromeres. PMID: 25942623 Autoantibodies to both CENP-A and CENP-B are markers for scleroderma and other rheumatic diseases. PMID: 17210244 Source: Regenstrief LOINC , UniProt: P07199

Fully-Specified Name

Component: Centromere protein B Ab
Property: PrThr
Time: Pt
System: Ser
Scale: Ord
Method: IB

Additional Names

Long Common Name: Centromere protein B Ab [Presence] in Serum by Immunoblot
Short Name: Centromere B Ab Ser Ql IB
Display Name: Centromere protein B Ab IB Ql (S)
Consumer Name Alpha Get Info: Centromere Protein B antibody, Blood

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.29
Last Updated: Version 2.58 (MIN)
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both

Member of these Groups Get Info

LOINC Group	Group Name
LG21820-2	Centromere protein B Ab\|PrThr\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
de-AT	German (Austria)	Synonyms: CENP-B-AK ql. IB
de-DE	German (Germany)	Zentromerprotein B Ak:Nachweis oder Schwellenwert:Zeitpunkt:Serum:Ordinal:Immunoblot Synonyms: CENP
el-GR	Greek (Greece)	Πρωτεΐνη κεντρομερούς Β Αντίσωμα:PrThr:Pt:Ορός:Ord:IB Synonyms: B PrThr Κεντρομερίδιο Πρωτεΐνη Πρωτεΐνη κεντρομερούς Β
es-ES	Spanish (Spain)	Proteína B del centrómero Anticuerpos:PrThr:Punto temporal:Suero:Ord:Inmunoblot (IB)
es-MX	Spanish (Mexico)	Centrómero de proteína B Ab:Presencia o umbral:Punto temporal:Suero:Ordinal:Inmunotransferencia
et-EE	Estonian (Estonia)	Tsentromeer B vastased antikehad:PrThr:Pt:S:Ord:IB Synonyms: Järgarvuline Juhuslik Seerum
fr-CA	French (Canada)	Centromère protéine B, Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Immunoblot
fr-FR	French (France)	Centromère protéine B anticorps:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Immunoblot
fr-BE	French (Belgium)	Centromère. Protéine B Ac:PrThr:Temps ponctuel:Sérum:Ordinal:Immunoblot Synonyms: Anticorps
it-IT	Italian (Italy)	Centromero, proteina B Ab:PrThr:Pt:Siero:Ord:IB Synonyms: anticorpo Immunoblot (IB) Presenza o Soglia Proteina B del centromero Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL	Dutch (Netherlands)	centromeereiwit B As:aanwezigheid:moment:serum:ordinaal:immunoblotting Synonyms: antistof; antilichaam IB
pt-BR	Portuguese (Brazil)	Centromero proteína B Ac:#N/A:Pt:Soro:Ord:Imunoblot Synonyms: ; Prot; PR; Centromere B; CENP-B; CENPB; CRST syndrome; Arbitrary concentration; Point in time; Random; Serum; SR; Ql; Ordinal; QL; Qualitative; Qual; Screen; Western blot; WB; Immune blot; Immunobl; Blt; WBLOT; West blt; West blot; RIBA; Immunoblot; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; Serology
ru-RU	Russian (Russian Federation)	Центромерный протеин B Ат:PrThr:ТчкВрм:Сыв:Пор:ИБ Synonyms: Антитело Белок Иммуноблот (ИБ) Порядковый Сыворотка Точка во времени;Момент
tr-TR	Turkish (Turkey)	Sentromer protein B Ab:MevcEşik:Zmlı:Ser:Srl:IB Synonyms: Mevcut
zh-CN	Chinese (China)	着丝点蛋白 B 抗体:存在情况或阈值:时间点:血清:序数型:免疫印迹法 Synonyms: Ab;自身抗体 B 型 B型抗体 CRST 综合征;着丝粒;动粒 PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型免疫印迹;西部印迹法;Immunoblot;immunoblotting;IB 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）时刻;随机;随意;瞬间着丝粒蛋白 B;动粒蛋白 B 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

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Copyright © 2025 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.