Log In

Part Description

LP65144-5   21-Deoxycortisol
Plasma 21-deoxycortisol (21DF) is an excellent marker of 21-hydroxylase deficiency. Currently, it is the only marker able to detect heterozygous carriers with 21-hydroxylase deficiency after Adrenocorticotropic Hormone (ACTH) stimulation. The syndrome of congenital adrenal hyperplasia (CAH) comprises the spectrum of autosomal recessive enzymatic disorders that impair cortisol biosynthesis. The hormonal pattern and clinical manifestations result from hyperstimulation of the adrenal cortex by excessive production of ACTH, untied from the negative feedback exerted by reduced cortisol levels, and the ultimate accumulation of F precursors and androgens. These abnormalities predispose the female newborn to ambiguous genitalia (female pseudohermaphroditism) and precocious puberty that may occur in both sexes. CAH due to 21-hydroxylase deficiency (21OHD) comprises nearly 90% of all cases, with an estimated worldwide incidence of 1 in 14,000 live births. Because 21-deoxycortisol (21DF) is an 11b-hydroxylase (11bOH) derivative of 17-hydroxyprogesterone (17OHP), its serum levels are parallel and proportionally elevated in patients with 21OHD but decreased or undetectable in those with 11b-hydroxylase deficiency (11bOHD). Due to the marked buildup of 17OHP in 21OHD, this precursor steroid can proceed directly to 11-hydroxylation, producing distinct elevations of 21DF. PMID: 16551734, PMID: 10731638 Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, 21-Deoxycortisol

LOINC Names Get Info

Fully-Specified Name
21-Deoxycortisol^pre dose dexamethasone:SCnc:Pt:Ser/Plas:Qn:
Long Common Name
21-Deoxycortisol [Moles/volume] in Serum or Plasma --pre dose dexamethasone
Short Name
21DC Pre Dex SerPl-sCnc
Display Name
21-Deoxycortisol pre dose dexamethasone [Moles/Vol]
Consumer Name Alpha Get Info
21-Deoxycortisol before dose dexamethasone, Blood

Part Model Get Info

  • Component
    21-Deoxycortisol^pre dose dexamethasone
    LP304787-7
    • Analyte
      21-Deoxycortisol
      LP65144-5
      • Component Numerator
        21-Deoxycortisol
        LP65144-5
        • Component Numerator Core
          21-Deoxycortisol
          LP65144-5
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      pre dose dexamethasone
      LP35651-6
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    SCnc
    LP6860-3
  • Time
    Pt
    LP6960-1
  • System
    Ser/Plas
    LP7576-4
    • System Core
      Ser/Plas
      LP7576-4
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    NULL
     

Basic Attributes

Class
CHAL
Type
Laboratory
First Released
Version 2.29
Last Updated
Version 2.70 (MIN)
Order vs. Observation
Observation

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)21-deoxykortizol^Před dávkou dexamethasonu:Látková koncentrace:Časový bod:Sérum/plazma:Kvantitativní:
el-GRGreek (Greece)21-δεοξυκορτιζόλη^προ δόσης δεξαμεθαζόνης:SCnc:Pt:Ορός/Πλάσμα:Qn:
Synonyms: 21-δεοξυκορτιζόλη CHAL Pt Qn SCnc Δεξαμεθαζόνη Ορός Ορός/Πλάσμα Πλάσμα προ δόσης προ δόσης δεξαμεθαζόνης
es-ESSpanish (Spain)21-Deoxicortisol^Pre dosis dexametasona:Concentración de sustancia:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
es-MXSpanish (Mexico)21-desoxicortisol^ predosis dexametasona:Concentración de sustancias:Punto temporal:Suero o Plasma:Cuantitativo:
fr-CAFrench (Canada)21-désoxycortisol^pré dose dexaméthasone:Concentration de substance:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-FRFrench (France)21-déoxycortisol^avant dexaméthasone:Moles/Volume:Ponctuel:Sérum/Plasma:Numérique:
fr-BEFrench (Belgium)21-déoxycortisol^Pré dose dexaméthasone:Concentration de substance:Temps ponctuel:Sérum/Plasma:Quantitatif:
Synonyms: Avant dose
it-ITItalian (Italy)21-Deossicortisolo^pre dose desametasone:SCnc:Pt:Siero/Plasma:Qn:
Synonyms: Concentrazione di Sostanza Plasma prima di dose prima di dose di desametasone Punto nel tempo (episodio) Siero Siero o Plasma Test di provocazione
nl-NLDutch (Netherlands)21-deoxycortisol^voor dosis dexamethason:mol/volume:moment:serum of plasma:kwantitatief:
pl-PLPolish (Poland)21-Deoksykortyzol^przed dawką deksametazonu:stężenie molowe:punkt w czasie:surowica lub osocze:ilościowy:
Synonyms: przed podaniem dawki przed podaniem dawki deksametazonu
pt-BRPortuguese (Brazil)21-Deoxicortisol^pré dose de dexametasona:#N/A:Pt:Sor/Plas:Qn:
Synonyms: Before; Decadron; Dexameth; Dexone; Hexadrol; 21DC; Pre Dex; Substance concentration; Level; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Quantitative; QNT; Quant; Quan; CHEMISTRY.CHALLENGE TESTING; CHEMISTRY.CHALLENGE TESTING
ru-RURussian (Russian Federation)21-Дезоксикортизол^до дозы дексаметазона:МолКонц:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Количественный Молярность;Молярная объёмная концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TRTurkish (Turkey)21-Deoksikortizol^önc dekzametazon dozu:SubKons:Zmlı:Ser/Plaz:Kant:
zh-CNChinese (China)21-脱氧皮质醇^在给予地塞米松之前:物质的量浓度:时间点:血清/血浆:定量型:
Synonyms: 21DC;21-脱氧可的索;21-脱氧氢化可的松;21-脱氧皮质甾醇;21-脱氧考的索 9α氟16甲基脱氢皮质甾醇;氟甲强的松龙;氟美松;甲氟烯索 XXX刺激 - 在...之前 一剂物质 一剂药物 之前于剂量物质;之前于剂量药物;在剂量物质之前 之前于给予地塞米松 克分子浓度;克分子浓度(单位体积);摩尔浓度;摩尔浓度(单位体积);物质的量浓度(单位体积) 剂量物质 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 血清或血浆

Example Units

UnitSource
nmol/LExample UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=57563-9