Version 2.77

Part Description

LP97940-8   HLA-B*15:02
The human leukocyte antigen B (HLA-B; [HGNC Gene ID: 4932]) plays an important role in how the immune system recognizes and responds to pathogens. HLA-B belongs to a class of molecules that are found on the surface of most cells. These molecules are responsible for presenting peptides to immune cells. Peptides derived from normal human proteins are recognized as such, whereas foreign peptides derived from pathogens trigger an immune response. Antiepileptics with an aromatic ring, for example carbamazepine and phenytoin, interact with HLA-B*15:02 and alter the repertoire of self-peptides that are presented to T lymphocytes, which activates an immune reaction known as Stevens-Johnson syndrome or toxic epidermal necrolysis. PMID: 23695185 PMID: 25099164. See https://www.pharmgkb.org/gene/PA35056 for more information and dosing guidelines for drugs impacted by HLA-B genetic variation. Source: Clinical Pharmacogenetics Implementation Consortium

Fully-Specified Name

Component
HLA-B*15:02
Property
PrThr
Time
Pt
System
Bld/Tiss
Scale
Ord
Method

Additional Names

Short Name
HLA-B*15:02 Ql
Display Name
HLA-B*15:02 Ql (Bld/Tiss)
Consumer Name Alpha Get Info
HLA-B*15:02, Blood or tissue specimen

Preferred Answer List: LL360-9

Source: Regenstrief Institute
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
HLA
Type
Laboratory
First Released
Version 2.29
Last Updated
Version 2.73
Change Reason
This test is commonly performed on cells found in saliva and buccal swabs as well as blood specimens. Changed specimen from 'Bld' to 'Bld/Tiss' to represent both specimen types.; The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Observation
Common Test Rank Get Info
15170

Member of these Panels

LOINC Long Common Name
94855-4 carBAMazepine hypersensitivity genotype panel - Blood or Tissue

Language Variants Get Info

Tag Language Translation
es-MX Spanish (Mexico) HLA-B * 15:2:Presencia o umbral:Punto temporal:Sangre o tejido:Ordinal
es-ES Spanish (Spain) HLA-B*15:02:PrThr:Punto temporal:Sangre o tejido:Ord:
et-EE Estonian (Estonia) HLA-B*1502:PrThr:Pt:B/Tis:Ord:
Synonyms: Järgarvuline Juhuslik Kude Veri Veri või koematerjal
fr-CA French (Canada) HLA-B*15:02:Présence-Seuil:Temps ponctuel:Sang/Tissu:Ordinal:
fr-FR French (France) HLA-B*15:02:Présence/Seuil:Ponctuel:Sang/Tissu:Qualitatif:
fr-BE French (Belgium) HLA-B*1502:PrThr:Temps ponctuel:Sang/Tissu:Ordinal:
it-IT Italian (Italy) HLA-B*15:02:PrThr:Pt:Sangue/Tess:Ord:
Synonyms: HLA tipizzazione tissutale antigeni-anticorpi Presenza o Soglia Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL Dutch (Netherlands) HLA-B*1502:aanwezigheid:moment:bloed of weefsel:ordinaal:
pt-BR Portuguese (Brazil) HLA-B*1502:#N/A:Pt:SgTotal:Ord:
Synonyms: Human Leukocyte Antigen; Arbitrary concentration; Point in time; Random; Blood; WB; Whole blood; Ql; Ordinal; QL; Qualitative; Qual; Screen; HLA ANTIGEN
ru-RU Russian (Russian Federation) HLA-B*1502:PrThr:ТчкВрм:Кр/Тк:Пор:
Synonyms: Кровь Кровь или Ткань Порядковый Ткань и мазки Точка во времени;Момент
tr-TR Turkish (Turkey) HLA-B*1502:MevcEşik:Zmlı:Kan/Dk:Srl:
Synonyms: Mevcut
zh-CN Chinese (China) HLA-B*15:02:存在情况或阈值:时间点:全血/组织:序数型:
Synonyms: B 型 HLA 抗原;人类白细胞抗原;human leukocyte antigen HLA-B*1502 人白细胞抗原 人类白细胞抗原 人类白细胞抗原(Human Leukocyte Antigen,HLA) 依次型;分类顺序型;定性的;序数型(或称等级型);性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 全血或组织;血液/组织;血液或组织 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况(存在、存在与否、是否存在)或阈值(界值、界限、阀值、临界值) 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 白细胞抗原 血;血液

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=57979-7