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Part Description

LP97963-0   Tetrahydrogestrinone
The identification of tetrahydrogestrinone (THG), the first true "designer androgen," as a sports doping agent reflects both an alarmingly sophisticated illicit manufacturing facility and an underground network of androgen abusers in elite sports, as well as the still untapped potential for designer androgens in medicine. Never marketed, THG was apparently developed as a potent androgen that was undetectable by conventional International Olympic Committee-mandated urinary sports doping tests. As a potent androgen and progestin with unspecified contaminants, its distribution for use at high doses without any prior biological or toxicological evaluation poses significant health risks. Yet this diversion of science also highlights the prospect of designer androgens for use in human medicine. Designer androgens also offer the possibility of tissue-specific effects enhancing the beneficial effects of androgens while mitigating the undesirable ones. Further developments require better understanding of the post receptor tissue selectivity of androgens, comparable to the mechanism underlying that of partial estrogen agonists (SERMs). This experience highlights the ongoing need for vigilance to detect novel drug doping strategies in order to maintain fairness and safety in elite sports. This will require the deployment of generic catch-all tests, such as sensitive and specific in vitro androgen bioassays, coupled with the development of mass spectrometry-based tests for specific doping agents. Starting from gestrinone, chemists can synthesize THG in one reaction step. PMID: 15934041, PMID: 15292520 Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Tetrahydrogestrinone

LOINC Names Get Info

Fully-Specified Name
Tetrahydrogestrinone:PrThr:Pt:Urine:Ord:
Long Common Name
Tetrahydrogestrinone [Presence] in Urine
Short Name
Tetrahydrogestrinone Ur Ql
Display Name
Tetrahydrogestrinone Ql (U)
Consumer Name Alpha Get Info
Tetrahydrogestrinone, Urine

Part Model Get Info

  • Component
    Tetrahydrogestrinone
    LP97963-0
    • Analyte
      Tetrahydrogestrinone
      LP97963-0
      • Component Numerator
        Tetrahydrogestrinone
        LP97963-0
        • Component Numerator Core
          Tetrahydrogestrinone
          LP97963-0
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    Urine
    LP7681-2
    • System Core
      Urine
      LP7681-2
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    NULL
     

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.29
Last Updated
Version 2.56 (MIN)
Change Reason
The Property has been changed from ACnc to reflect the new model for ordinal terms where results are based on a cut-off value.; The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Tetrahydrogestrinon:Přítomnost nebo práh:Časový bod:Moč:Ordinální:
el-GRGreek (Greece)Τετραϋδρογεστρινόνη:PrThr:Pt:Ούρα:Ord:
Synonyms: DRUG/TOX Ord PrThr Pt Ούρα Τετραϋδρογεστρινόνη
es-ESSpanish (Spain)Tetrahidrogestriona:PrThr:Punto temporal:Orina:Ord:
es-MXSpanish (Mexico)Tetrahidrogestrinona:Presencia o umbral:Punto temporal:Orina:Ordinal:
et-EEEstonian (Estonia)Tetrahüdrogestrinon:PrThr:Pt:U:Ord:
Synonyms: Järgarvuline Juhuslik Uriin
fr-FRFrench (France)Tétrahydrogestrinone:Présence/Seuil:Ponctuel:Urine:Qualitatif:
fr-BEFrench (Belgium)Tétrahydrogestrinone:PrThr:Temps ponctuel:Urine:Ordinal:
it-ITItalian (Italy)Tetraidrogestrinone:PrThr:Pt:Urine:Ord:
Synonyms: Livelli farmacologici e tossicologia Presenza o Soglia Punto nel tempo (episodio)
nl-NLDutch (Netherlands)tetrahydrogestrinon:aanwezigheid:moment:urine:ordinaal:
pl-PLPolish (Poland)Tetrahydrogestrinon:granica wykrywalności:punkt w czasie:mocz:uporządkowany:
pt-BRPortuguese (Brazil)Tetrahidrogestrinona:#N/A:Pt:Urina:Ord:
Synonyms: Arbitrary concentration; Point in time; Random; Ur; UR; Urn; UA; Ql; Ordinal; QL; Qualitative; Qual; Screen; Drugs; DRUG/TOXICOLOGY; DRUG/TOXICOLOGY
ru-RURussian (Russian Federation)Тетрагидрогестринон:PrThr:ТчкВрм:Моча:Пор:
Synonyms: Порядковый Точка во времени;Момент
tr-TRTurkish (Turkey)Tetrahidrogestrinon:MevcEşik:Zmlı:İdrar:Srl:
Synonyms: Mevcut
zh-CNChinese (China)四氢孕三烯酮:存在情况或阈值:时间点:尿液:序数型:
Synonyms: 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 四氢乙基羟基二降孕三烯炔酮;四氢甲地炔诺酮 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 尿;小便;下泉 时刻;随机;随意;瞬间 毒品 毒品类 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=58028-2