Version 2.78

Part Description

LP18489-2   Glutamate decarboxylase 65
Glutamate decarboxylase 65 (GAD65) antibody is useful to diagnose insulin dependent diabetes mellitus (IDDM, Type I diabetes), to assess the risk for developing IDDM, to predict the onset of IDDM and the risk of developing related endocrine disorders such as thyroiditis. Before clinical onset, Type I diabetes is characterized by lymphocytic infiltration of the islet cells and by circulating autoantibodies against a variety of islet cell antigens including GAD-65, IA-2 (a tyrosine phosphatase-like protein), and insulin (IAA). GAD has two isoforms, GAD65 and GAD67, which are highly homologous but found in distinct subsets of patients. PMID: 7532143 GAD65 antibodies are specific to patients with insulin-dependent diabetes. The presence of GAD antibodies in a patient recently diagnosed with diabetes indicates a high risk of requiring insulin within three years. PMID: 11114103 GAD67 is important to the maturation of perisomatic innervation.( http://www.sciencedirect.com/science/article/pii/S0896627307003728) GAD65 are also associated with paraneoplastic neurologic syndrome (PNS) which is an autoimmune disorder that is manifested by progressive neurological syndromes of any combination of the central, peripheral and autonomic nervous systems. In addition, the different PNS antibodies are associated with certain cancers and can assist in identifying where an unknown tumor is located. PMID: 22412264 Glutamic acid decarboxylase 65 antibody are associated with stiff person syndrome, cerebellar ataxia encephalitis and other neurological diseases. PMID: 22405456 Source: Regenstrief LOINC

Fully-Specified Name

Component
Glutamate decarboxylase 65 Ab
Property
MCnc
Time
Pt
System
Ser
Scale
Qn
Method

Additional Names

Short Name
GAD65 Ab Ser-mCnc
Display Name
Glutamate decarboxylase 65 Ab (S) [Mass/Vol]
Consumer Name Alpha Get Info
Glutamate decarboxylase 65 antibody, Blood

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.32
Last Updated
Version 2.70
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG46737-9 Glutamate decarboxylase 65 Ab|Pt|Ser

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Glutamato decarboxilasa 65 Anticuerpos:Concentración de masa:Punto temporal:Suero:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Glutamato descarboxilasa 65 Ab:Concentración de masa:Punto temporal:Suero:Cuantitativo:
et-EE Estonian (Estonia) Glutamaadi dekarboksülaasi 65 vastased antikehad:MCnc:Pt:S:Qn:
Synonyms: Juhuslik Kvantitatiivne Seerum
fr-CA French (Canada) Glutamate décarboxylase 65, Ac:Concentration de masse:Temps ponctuel:Sérum:Quantitatif:
fr-FR French (France) Glutamate décarboxylase 65 anticorps:Masse/Volume:Ponctuel:Sérum:Numérique:
fr-BE French (Belgium) Glutamate décarboxylase 65 Ac:Concentration de masse:Temps ponctuel:Sérum:Quantitatif:
Synonyms: Anticorps
it-IT Italian (Italy) Glutammato decarbossilasi 65 Ab:MCnc:Pt:Siero:Qn:
Synonyms: anticorpo Concentrazione di Massa GAD65 Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) glutamaatdecarboxylase 65 As:massa/volume:moment:serum:kwantitatief:
Synonyms: antistof; antilichaam
pt-BR Portuguese (Brazil) Glutamato descarboxilase 65 Ac::Pt:Soro:Qn:
ru-RU Russian (Russian Federation) Глутаматдекарбоксилаза 65 Ат:МассКонц:ТчкВрм:Сыв:Колич:
Synonyms: Антитело Количественный Массовая концентрация Сыворотка Точка во времени;Момент
tr-TR Turkish (Turkey) Glutamat dekarboksilaz 65 Ab:KütlKons:Zmlı:Ser:Kant:
Synonyms: Ak
zh-CN Chinese (China) 谷氨酸脱羧酶-65 抗体:质量浓度:时间点:血清:定量型:
Synonyms: Ab;自身抗体 GAD65;GAD-65;谷氨酸脱羧酶 65;谷氨酸脱羧酶 65（Glutamate Decarboxylase 65，GAD65，Glutamic acid decarboxylase-65，GAD-65） GADA Glu 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 水平;浓度;质量浓度(单位体积) 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类 谷氨酸脱羧酶 65 Ab 谷氨酸脱羧酶 65 抗体 谷氨酸脱羧酶-65 Ab 麸胺酸去羧酶;麸胺酸去羧基酶;麸氨酸去羧基酶;GAD

Example Units

Unit Source
pg/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=58451-6