58899-6

Aldosterone [Mass/volume] in Serum or Plasma --4 hours post XXX challenge

Active

Part Descriptions

LP14377-3   Aldosterone
Aldosterone is a steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland to regulate sodium and potassium balance in the blood. It is synthesized from cholesterol by aldosterone synthase, which is absent in other sections of the adrenal gland. It is the sole endogenous member of the class of mineralocorticoids. Acting on mineralocorticoid receptors (MR) on principal cells in the collecting ducts of the kidneys, it increases the permeability of their apical (luminal) membrane to potassium and sodium and activates their basolateral Na+K+ pumps, stimulating ATP hydrolysis, reabsorbing sodium (Na+) ions and water into the blood, and excreting potassium (K+) ions into the urine. Aldosterone also stimulates H+ secretion by intercalated cells in the collecting duct, regulating plasma bicarbonate (HCO3-) levels and its acidbase balance. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Aldosterone (Wikipedia)

LP14377-3   Aldosterone
Used to detect hyper and hypo aldosteronisnm. Hypoaldosteronism can occur in any condition that causes destruction or dysfunction of the adrenal gland.1,2,4 Hypoaldosterism can be due to primary adrenal insufficiency , congenital adrenal hypoplasia, acquired secondary aldosterone deficiency (hyporeninemic hypoaldosteronism), and acquired Hyporeninemic hypoaldosteronism is the most common form of isolated hypoaldosteronism and is results from impaired renin release from the kidney. Congenital hypoaldosteronism caused by inherited enzymatic defects in aldosterone biosynthesis are rare. Corticosterone methyloxidase I (CMO I) deficiency is associated with elevated serum levels of corticosterone and low levels of 18-hydroxy-corticosterone and aldosterone. Corticosterone methyloxidase II (CMO II) deficiency produces high levels of 18-hydroxy-corticosterone, the immediate precursor of aldosterone.
Acquired primary hypoaldosteronism can be caused by the administration of heparin. Also, persistently hypotensive, critically ill patients with sepsis, pneumonia, peritonitis, cholangitis, and liver failure can have inappropriately low plasma aldosterone concentrations in relation to elevated plasma renin activity. Primary hyperaldosteronism, also referred to as Conn syndrome, is due to overproduction of aldosterone by one or both of the adrenal glands. Some recent studies suggest that 10% to 15% of Hyper thyroidism cases are due to (or associated with ) primary hyperaldosteronism. Secondary hyperaldosteronism is relatively common and can occur as the result of any condition that decreases blood flow to the kidneys (ie, renal artery stenosis), decreases blood pressure, or lowers plasma sodium levels. Secondary hyperaldosteronism may also be seen with cirrhosis, congestive heart failure. and toxemia of pregnancy. Several studies have suggested that high-normal aldosterone levels predict development of high blood pressure in normotensive subjects and that increased aldosterone action contributes to hypertension, cardiovascular fibrosis, and cardiac hypertrophy. Source: Regenstrief Institute

LOINC Names Get Info

Fully-Specified Name

Aldosterone^4H post XXX challenge:MCnc:Pt:Ser/Plas:Qn:

Long Common Name

Aldosterone [Mass/volume] in Serum or Plasma --4 hours post XXX challenge

Short Name

Aldost 4h p chal SerPl-mCnc

Display Name

Aldosterone 4 Hr post Unsp challenge [Mass/Vol]

Consumer Name Alpha Get Info

Aldosterone 4 hr after challenge, Blood

Part Model Get Info

• Component

  Aldosterone^4H post XXX challenge
  LP304865-1

  • Analyte

    Aldosterone
    LP14377-3

    • Component Numerator

      Aldosterone
      LP14377-3

      • Component Numerator Core

        Aldosterone
        LP14377-3

      • Component Numerator Core Suffix

        NULL
         

    • Component Denominator

      NULL
       

      • Component Denominator Core

        NULL
         

      • Component Denominator Core Suffix

        NULL
         

  • Challenge

    4H post XXX challenge
    LP20455-9

  • Adjustment

    NULL
     

  • Count

    NULL
     

• Property

  MCnc
  LP6827-2

• Time

  Pt
  LP6960-1

  • Time Core

    Pt
    LP6960-1

  • Time Modifier

    NULL
     

• System

  Ser/Plas
  LP7576-4

  • System Core

    Ser/Plas
    LP7576-4

  • Super System

    NULL
     

• Scale

  Qn
  LP7753-9

• Method

  NULL
   

Basic Attributes

Class

CHAL

Type

Laboratory

First Released

Version 2.32

Last Updated

Version 2.70 (MIN)

Order vs. Observation

Observation

Member of these Groups Get Info

Language Variants Get Info

Related Names

• 4h p chal
• After
• CHEMISTRY.CHALLENGE TESTING
• Endocrine
• Endocrinology
• Level
• Mass concentration
• p chal
• Pl
• Plasma
• Plsm
• Point in time
• PST
• QNT
• Quan
• Quant
• Quantitative
• Random
• SerP
• SerPl
• SerPlas
• Serum
• Serum or plasma
• SR

Example Units

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CodeSystem lookup

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=58899-6

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.