Version 2.77

Part Description

LP69897-4   U1 small nuclear ribonucleoprotein 70kD
U1 small nuclear ribonucleoprotein particle (U1 snRNP) is an RNA-protein complex that is composed of ten proteins: U1-70kD, U1A, U1C and seven Smith antigen (Sm) proteins. The U1 snRNP complex is responsible for pre-mRNA processing. Autoantibodies to different components of the U1 snRNP complex are associated with autoimmune conditions including systemic lupus erythematosus (SLE) and mixed connective tissue disorders (MCTD), which includes systemic sclerosis. The pattern of autoantibodies present in an individual patient may help distinguish between different connective tissue disorders. For example, patients with anti-U1A and anti-U1C IgM antibodies are more likely to have SLE than MCTD. PMID: 24158973 In addition, there is some evidence that specific antibody patterns are associated with specific symptoms. For example, among patients with SLE, the combination of anti-U1-70kD, anti-U1A and anti-U1C correlates with Raynaud's phenomenon, while anti-U1-70kD and anti-U1A (without anti-U1C) correlate with leukopenia. Another study found an association between the number of specific positive antibodies within the anti-U1 snRNP (rather than the presence of particular markers) and certain clinical features. For example, patients with three or more positive autoantibodies were more likely to have features of systemic sclerosis and less likely to have renal disease compared to patients with fewer types of antibodies. PMID: 20015915 Source: Regenstrief LOINC, PMID: 24158973

Fully-Specified Name

Component
U1 small nuclear ribonucleoprotein 70kD Ab
Property
ACnc
Time
Pt
System
Ser
Scale
Qn
Method

Additional Names

Short Name
U1 snRNP70 Ab Ser-aCnc
Display Name
U1 small nuclear ribonucleoprotein 70kD Ab Qn (S)
Consumer Name Alpha Get Info
U1 small nuclear ribonucleoprotein 70kD antibody, Blood

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.32
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
14046

Member of these Groups Get Info

LOINC Group Group Name
LG24688-0 U1 small nuclear ribonucleoprotein 70kD Ab|ACnc|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: RNP70-AK
es-ES Spanish (Spain) U1 ribonucleoproteína nuclear pqueña de 70kD Anticuerpos:Concentración arbitraria:Punto temporal:Suero:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Ribonucleoproteína nuclear sub U1 70kD Ab:Concentración arbitraria:Punto temporal:Suero:Cuantitativo:
fr-CA French (Canada) Petite particule nucléaire ribonucléoprotéique U1 70kD , Ac:Concentration arbitraire:Temps ponctuel:Sérum:Quantitatif:
fr-FR French (France) RNP 70kD anticorps:Arbitraire/Volume:Ponctuel:Sérum:Numérique:
fr-BE French (Belgium) Petite particule nucléaire ribonucléoprotéique U1 70kD Ac:Concentration arbitraire:Temps ponctuel:Sérum:Quantitatif:
Synonyms: Anticorps
it-IT Italian (Italy) U1, piccola ribonucleoproteina nucleare 70kD Ab:ACnc:Pt:Siero:Qn:
Synonyms: anticorpo Concentrazione Arbitraria Piccola ribonucleoproteina nucleare U1 Piccola ribonucleoproteina nucleare U1 70kD Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) u1 small nucleair ribonucleoproteïne 70kD As:eenheid/volume:moment:serum:kwantitatief:
Synonyms: antistof; antilichaam
pt-BR Portuguese (Brazil) RNP 70kD Ac::Pt:Soro:Qn:
ru-RU Russian (Russian Federation) U1 малый ядерный рибонуклеопротеин 70кД Ат:ПроизвКонц:ТчкВрм:Сыв:Колич:
Synonyms: Антитело Количественный Произвольная концентрация Сыворотка Точка во времени;Момент
tr-TR Turkish (Turkey) U1 kçk nükleer ribonükleoprotein 70kD Ab:SçKons:Zmlı:Ser:Kant:
Synonyms: Ak Çekirdek
zh-CN Chinese (China) U1 小细胞核核糖核蛋白 70kD 抗体:任意型浓度:时间点:血清:定量型:
Synonyms: Ab;自身抗体 RNP snRNP U1 RNP 70kD;U1 snRNP 70kD;U1 小细胞核核糖核蛋白 70kD;U1 small nuclear ribonucleoprotein 70kD;U1RNP 70kD U1 RNP;U1 snRNP;U1 小细胞核核糖核蛋白;U1 small nuclear ribonucleoprotein;U1RNP 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 小分子核糖核蛋白体 小分子细胞核核糖核蛋白 小核核糖核蛋白（Small nuclear ribonucleoprotein，snRNP） 时刻;随机;随意;瞬间 核;胞核 核内小核糖核蛋白 核微小核糖核蛋白 核糖核蛋白（Ribonucleoprotein，Ribonuclear protein，RNP） 核蛋白 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Example Units

Unit Source
[arb'U]/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=59026-5