59377-2

2-Methylacetoacetate/Creatinine [Molar ratio] in Urine

Active

Part Descriptions

LP100176-9 2-Methylacetoacetate
2-Methylacetoacetic acid is a metabolite that has an increased excretion in patients with acetoacetyl-CoA thiolase deficiency. Thiolases are ubiquitous and important enzymes. Several isoenzymes are known, which can occur in the cytosol (ACAT2), the mitochondria (ACAT1), or the peroxisomes (ACAA2). Thiolases are CoA-dependent enzymes which catalyze the formation of a carbon-carbon bond in a Claisen condensation step and its reverse reaction via a thiolytic degradation mechanism. Mitochondrial acetoacetyl-coenzyme A (CoA) thiolase (T2) is important in the pathways for the synthesis and degradation of ketone bodies as well as for the degradation of 2-methylacetoacetyl-CoA. PMID: 17371050, PMID: 14518824, PMID: 9744475, PMID: 9001814 Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database , 2-Methylacetoacetate

LP32035-5 Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database , Creatinine

Fully-Specified Name

Component: 2-Methylacetoacetate/Creatinine
Property: SRto
Time: Pt
System: Urine
Scale: Qn
Method

Additional Names

Long Common Name: 2-Methylacetoacetate/Creatinine [Molar ratio] in Urine
Short Name: 2-Methylacetoacetate/Creat Ur-sRto
Display Name: 2-Methylacetoacetate/Creatinine (U) [Molar ratio]
Consumer Name Alpha Get Info: 2-Methylacetoacetate/Creatinine, Urine

Basic Attributes

Class: CHEM
Type: Laboratory
First Released: Version 2.32
Last Updated: Version 2.73 (MIN)
Order vs. Observation: Both
Common Test Rank Get Info: 12183

Language Variants Get Info

Tag	Language	Translation
el-GR	Greek (Greece)	2-Ακετοξικό μεθύλιο/Κρεατινίνη:SRto:Pt:Ούρα:Qn: Synonyms: 2-Ακετοξικό μεθύλιο SRto Κρεατινίνη
es-ES	Spanish (Spain)	2-Metilacetoacetato/Creatinina:Relacion de Sustancia:Punto temporal:Orina:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	2-metilacetoacetato / creatinina:Proporción de sustancia:Punto temporal:Orina:Cuantitativo:
fr-CA	French (Canada)	2-méthylacétoacetate/Créatinine:Ratio de substance:Temps ponctuel:Urine:Quantitatif:
fr-FR	French (France)	2-méthylacétoacetate/créatinine:Moles ratio:Ponctuel:Urine:Numérique:
fr-BE	French (Belgium)	2-Methylacetoacetate/Créatinine:Ratio de substance:Temps ponctuel:Urine:Quantitatif: Synonyms: 2-Méthyl-acétoacétate
it-IT	Italian (Italy)	2-Metilacetoacetato/Creatinina:Srto:Pt:Urine:Qn: Synonyms: Chimica Punto nel tempo (episodio) Rapporto di sostanza
nl-NL	Dutch (Netherlands)	2-methylacetoacetaat/creatinine:molaire verhouding:moment:urine:kwantitatief: Synonyms: kreatinine
pt-BR	Portuguese (Brazil)	2-Metilacetoacetato/Creatinina::Pt:Urina:Qn:
ru-RU	Russian (Russian Federation)	2-метилацетоацетат/Креатинин:МольОтн:ТчкВрм:Моча:Колич: Synonyms: Количественный Мольная доля;Молярная доля;Отношение концентраций Точка во времени;Момент
tr-TR	Turkish (Turkey)	2-Metilasetoasetat/Kreatinin:SOrn:Zmlı:İdrar:Kant: Synonyms: SubsOranı
zh-CN	Chinese (China)	2-甲基乙酰乙酸乙酯/肌酐:物质的量比率:时间点:尿液:定量型: Synonyms: Ⅱ CR;Creat;肌氨酸酐;肌酸内酰胺;肌酸酐 II UCr α-丁酮酸乙酯;Α-丁酮酸乙酯;甲基乙醯乙酸乙酯;Α-甲基乙酰乙酸乙酯;Α-甲基乙酰乙酸乙酯化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类可用数量表示的;定量性;数值型;数量型;连续数值型标尺尿;小便;下泉尿液肌酐尿液肌酸酐尿肌酸酐时刻;随机;随意;瞬间物质的量比值;物质的量比;摩尔比;摩尔比率;摩尔比值肌酸内酰胺

Example Units

Unit	Source
mmol/mol{creat}	Example UCUM Units

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