LP100176-9
2-Methylacetoacetate
Active
Description
2-Methylacetoacetic acid is a metabolite that has an increased excretion in patients with acetoacetyl-CoA thiolase deficiency. Thiolases are ubiquitous and important enzymes. Several isoenzymes are known, which can occur in the cytosol (ACAT2), the mitochondria (ACAT1), or the peroxisomes (ACAA2). Thiolases are CoA-dependent enzymes which catalyze the formation of a carbon-carbon bond in a Claisen condensation step and its reverse reaction via a thiolytic degradation mechanism. Mitochondrial acetoacetyl-coenzyme A (CoA) thiolase (T2) is important in the pathways for the synthesis and degradation of ketone bodies as well as for the degradation of 2-methylacetoacetyl-CoA. PMID: 17371050, PMID: 14518824, PMID: 9744475, PMID: 9001814 Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database , 2-Methylacetoacetate
Basic Part Properties
- Part Name
- 2-Methylacetoacetate
- Part Display Name
- 2-Methylacetoacetate
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2010-04-09
- Construct for LOINC Short Name
- 2-Methylacetoacetate
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| et-EE | Estonian (Estonia) | 2-metüülatseetoatsetaat |
| it-IT | Italian (Italy) | 2-Metilacetoacetato |
| es-ES | Spanish (Spain) | 2-Metilacetoacetato |
| zh-CN | Chinese (China) | 2-甲基乙酰乙酸乙酯 Synonyms: α-丁酮酸乙酯; |
| tr-TR | Turkish (Turkey) | 2-Metilasetoasetat |
| ru-RU | Russian (Russian Federation) | 2-метилацетоацетат |
| fr-BE | French (Belgium) | 2-Methylacetoacetate Synonyms: 2-Méthyl-acétoacétate |
| fr-CA | French (Canada) | 2-méthylacétoacetate |
| nl-NL | Dutch (Netherlands) | 2-methylacetoacetaat |
| el-GR | Greek (Greece) | 2-Ακετοξικό μεθύλιο Synonyms: 2-Ακετοξικό μεθύλιο |
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